The effect of left frontal transcranial direct-current stimulation on propranolol-induced fear memory acquisition and consolidation deficits

Nasehi, Mohammad; Khani-Abyaneh, Mozhgan; Ebrahimi-Ghiri, Mohaddeseh; Zarrindast, Mohammad‐Reza

doi:10.1016/j.bbr.2017.04.055

Cited by 14 publications

(12 citation statements)

References 58 publications

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“…Similar results were observed in rodents, in which tDCS (100–350 μA; 20 min) applied over PFC, temporal cortex or hippocampus boosts memories (object-recognition, spatial and fear memories) in both physiological ( Binder et al, 2014 ; Podda et al, 2016 ; Manteghi et al, 2017 ; Nasehi et al, 2017 ) and pathological models, including AD ( Yu et al, 2015 ) and traumatic brain injury (TBI) ( Yoon et al, 2016 ).…”

Section: Introductionsupporting

confidence: 73%

Role of BDNF Signaling in Memory Enhancement Induced by Transcranial Direct Current Stimulation

2018

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In the recent years numerous studies have provided encouraging results supporting the use of transcranial direct current stimulation (tDCS) as non-invasive brain stimulation technique to improve motor and cognitive functions in patients suffering from neurological and neuropsychiatric disorders as well as in healthy subjects. Among the multiple effects elicited by tDCS on cognitive functions, experimental evidence and clinical findings have highlighted the beneficial impact on long-term memory. Memory deficits occur during physiological aging as well as in neurological and neurodegenerative disorders, including Alzheimer’s disease (AD). In this scenario, non-invasive techniques for memory enhancement, such as tDCS, are receiving increasing attention. The knowledge of molecular mechanisms subtending tDCS effects is of pivotal importance for a more rationale use of this technique in clinical settings. Although we are still far from having a clear picture, recent literature on human and animal studies has pointed to the involvement of synaptic plasticity mechanisms in mediating tDCS effects on long-term memory. Here we review these studies focusing on the neurotrophin “brain-derived neurotrophic factor” (BDNF) as critical tDCS effector.

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Section: Introductionsupporting

confidence: 73%

Role of BDNF Signaling in Memory Enhancement Induced by Transcranial Direct Current Stimulation

2018

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“…Right frontal anodal tDCS administered 24 h before behavioral task did not alter contextual and auditory learning and memory [36]. Additionally, another study described that while the anodal stimulation did not affect fear retrieval, posttraining cathodal stimulation improved fear memory retrieval [37,38]. However, left prefrontal anodal and cathodal tDCS impaired the acquisition of both contextual and cued fear memory, which could be explained by activity modulation of deep structures such as the amygdala and hippocampus [39].…”

Section: Role Of Anodal Tdcs In Cognition Processing In Healthymentioning

confidence: 99%

Memory and Cognition-Related Neuroplasticity Enhancement by Transcranial Direct Current Stimulation in Rodents: A Systematic Review

2020

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Brain stimulation techniques, including transcranial direct current stimulation (tDCS), were identified as promising therapeutic tools to modulate synaptic plasticity abnormalities and minimize memory and learning deficits in many neuropsychiatric diseases. Here, we revised the effect of tDCS on the modulation of neuroplasticity and cognition in several animal disease models of brain diseases affecting plasticity and cognition. Studies included in this review were searched following the terms (“transcranial direct current stimulation”) AND (mice OR mouse OR animal) and according to the PRISMA statement requirements. Overall, the studies collected suggest that tDCS was able to modulate brain plasticity due to synaptic modifications within the stimulated area. Changes in plasticity-related mechanisms were achieved through induction of long-term potentiation (LTP) and upregulation of neuroplasticity-related proteins, such as c-fos, brain-derived neurotrophic factor (BDNF), or N-methyl-D-aspartate receptors (NMDARs). Taken into account all revised studies, tDCS is a safe, easy, and noninvasive brain stimulation technique, therapeutically reliable, and with promising potential to promote cognitive enhancement and neuroplasticity. Since the use of tDCS has increased as a novel therapeutic approach in humans, animal studies are important to better understand its mechanisms as well as to help improve the stimulation protocols and their potential role in different neuropathologies.

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“…The aim of this study was to investigate the effect of repeated anodal tDCS over the PFC on auditory fear extinction and generalization in mice. In our experimental set-up, the stimulation electrode was surgically placed over the left PFC, similar to previous work in mice [65,67,75,76]. While the lateralization of brain function is not established in rodents, these previous studies found that anodal tDCS over the left PFC affect fear memory [65], depressionlike behavior [67,75], and bilateral changes in c-Fos expression in cortical regions (IL) and subcortical regions (HPC) [67].…”

Section: Introductionmentioning

confidence: 91%

“…In our experimental set-up, the stimulation electrode was surgically placed over the left PFC, similar to previous work in mice [65,67,75,76]. While the lateralization of brain function is not established in rodents, these previous studies found that anodal tDCS over the left PFC affect fear memory [65], depressionlike behavior [67,75], and bilateral changes in c-Fos expression in cortical regions (IL) and subcortical regions (HPC) [67]. Furthermore, we applied a repeated anodal tDCS procedure which was previously demonstrated to be effective in preclinical studies [67,75] and clinical studies for depression [54e56].…”

Section: Introductionmentioning

confidence: 99%

Effects of repeated anodal transcranial direct current stimulation on auditory fear extinction in C57BL/6J mice

et al. 2021

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Background: Trauma-based psychotherapy is a first line treatment for post-traumatic stress disorder (PTSD) but not all patients achieve long-term remission. Transcranial direct current stimulation (tDCS) received considerable attention as a neuromodulation method that may improve trauma-based psychotherapy. Objective: We explored the effects of repeated anodal tDCS over the prefrontal cortex (PFC) on fear extinction in mice as a preclinical model for trauma-based psychotherapy. Methods: We performed auditory fear conditioning with moderate or high shock intensity on C57BL6/J mice. Next, mice received anodal tDCS (0.2 mA, 20 min) or sham stimulation over the PFC twice daily for five consecutive days. Extinction training was performed by repeatedly exposing mice to the auditory cue the day after the last stimulation session. Early and late retention of extinction were evaluated one day and three weeks after extinction training respectively. Results: We observed no significant effect of tDCS on the acquisition or retention of fear extinction in mice subjected to fear conditioning with moderate intensity. However, when the intensity of fear conditioning was high, tDCS significantly lowered freezing during the acquisition of extinction, regardless of the extinction protocol. Moreover, when tDCS was combined with a strong extinction protocol, we also observed a significant improvement of early extinction recall. Finally, we found that tDCS reduced generalized fear induced by contextual cues when the intensity of conditioning is high and extinction training limited. Conclusions: Our data provide a rationale to further explore anodal tDCS over the PFC as potential support for trauma-based psychotherapy for PTSD.

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The effect of left frontal transcranial direct-current stimulation on propranolol-induced fear memory acquisition and consolidation deficits

Cited by 14 publications

References 58 publications

Role of BDNF Signaling in Memory Enhancement Induced by Transcranial Direct Current Stimulation

Role of BDNF Signaling in Memory Enhancement Induced by Transcranial Direct Current Stimulation

Memory and Cognition-Related Neuroplasticity Enhancement by Transcranial Direct Current Stimulation in Rodents: A Systematic Review

Effects of repeated anodal transcranial direct current stimulation on auditory fear extinction in C57BL/6J mice

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