The Effect of Isomaltulose Together with Green Tea on Glycemic Response and Antioxidant Capacity: A Single-Blind, Crossover Study in Healthy Subjects

Abstract

Isomaltulose, a naturally-occurring isomer of sucrose, is commonly used as an alternative sweetener in foods and beverages. The goal of this study was to determine the effect of isomaltulose together with green tea on postprandial plasma glucose and insulin concentration, as well as antioxidant capacity in healthy subjects. In a randomized, single-blind, crossover study, 15 healthy subjects (eight women and seven men; ages 23.5 ± 0.7 years; with body mass index of 22.6 ± 0.4 kg/m2) consumed five beverages: (1) 50 g sucrose in 400 mL water; (2) 50 g isomaltulose in 400 mL of water; (3) 400 mL of green tea; (4) 50 g sucrose in 400 mL of green tea; and (5) 50 g isomaltulose in 400 mL of green tea. Incremental area under postprandial plasma glucose, insulin, ferric reducing ability of plasma (FRAP) and malondialdehyde (MDA) concentration were determined during 120 min of administration. Following the consumption of isomaltulose, the incremental 2-h area under the curve (AUC0–2 h) indicated a higher reduction of postprandial glucose (43.4%) and insulin concentration (42.0%) than the consumption of sucrose. The addition of green tea to isomaltulose produced a greater suppression of postprandial plasma glucose (20.9%) and insulin concentration (37.7%). In accordance with antioxidant capacity, consumption of sucrose (40.0%) and isomaltulose (28.7%) caused the reduction of green tea-induced postprandial increases in FRAP. A reduction in postprandial MDA after drinking green tea was attenuated when consumed with sucrose (34.7%) and isomaltulose (17.2%). In conclusion, green tea could enhance the reduction of postprandial glucose and insulin concentration when consumed with isomaltulose. In comparison with sucrose, isomaltulose demonstrated less alteration of plasma antioxidant capacity after being consumed with green tea.

Effects of Polyphenol-Rich Foods on Human Health

“…This Special Issue “Effects of Polyphenol-Rich Foods on Human Health” comprises 64 peer-reviewed papers, including 43 original research papers [ 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 ], one case-report [ 51 ] and 20 literature reviews [ 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 , 62 ...…”

“…Epidemiological and clinical studies reported the following associations of polyphenols and polyphenol food extracts: silibinin and non-alcoholic fatty liver disease [ 9 , 39 ], resveratrol and hepatic encephalopathy [ 33 ], coffee polyphenols and cardiovascular risk factors [ 34 ], flavonoids and ventilator function [ 20 ], tea and stress and sleep quality (depending on caffeine content) [ 46 ], tea and glycemic response [ 44 ], polyphenols and obesity [ 24 ], phenolic acids and hypertension [ 22 ], healthy diet and neurofibromatosis [ 51 ].…”

Plasma and Salivary Non-Urate Total Antioxidant Capacity Does Not Depend on Dietary Vitamin C, E, or β-Carotene Intake in Older Subjects

“…Numerous interventional studies have assessed the potential impact of various nutritional compounds added to food [ 17 , 18 ] or beverages [ 19 ] in DFR on the antioxidant potential, or have examined the effect of individual antioxidants (UA, vitamin C, antioxidative enzymes) in plasma or serum, although few have used saliva. However, few studies have evaluated the influence of habitual dietary intake on the antioxidant status, especially its salivary non-urate fraction, which prevents a reliable comparison with the obtained data.…”

Health Functions and Related Molecular Mechanisms of Tea Components: An Update Review

“…In addition, regular intake of green tea could benefit high-fat diet-induced T2DM [151]. Meanwhile, green tea was found to augment the isomaltulose activity to reduce postprandial glucose and insulin concentration in healthy subjects [152]. Furthermore, supplementation with green tea extract could improve glycemic control and prevent osteoporosis in diabetic patients [153].…”