Effects of Polyphenol-Rich Foods on Human Health

Grosso, Giuseppe

doi:10.3390/nu10081089

Cited by 84 publications

(43 citation statements)

References 72 publications

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“…On the other hand, these agri-food residues (fruits, vegetables, etc.) present an opportunity for commercial exploitation [ 17 ], in the form of new products in the food industry (natural dye, as a food/nutritional quality enhancer) [ 9 , 11 , 13 , 19 , 20 ]; in the pharmaceutical industry (functional supplements) [ 21 , 22 , 23 ]; in the cosmetic industry (products with antioxidant and photoprotective effects and inhibition of dermal proteases) [ 24 ].…”

Section: Resultsmentioning

confidence: 99%

Effect of Drying Methods on Bioactive Compounds and Antioxidant Capacity in Grape Skin Residues from the New Hybrid Variety “BRS Magna”

et al. 2020

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The effects of the drying process using the conventional oven and freeze-drying on the thermogravimetric profile, proximate composition, color parameters, individual bioactive compounds, and antioxidant activity in the grape residue (skin) were evaluated. Twenty individual phenolic compounds were identified, where a variation in concentration was observed for flavonols, stilbenes, phenolic acids, flavonoids, procyanidins, and particularly anthocyanins (malvidin-3,5-di-O-glucoside of 253.2–536.9 mg/kg) due to the drying process. Drying in a conventional oven caused a decrease of 23% of the total polyphenols. The skin of the BRS magna grape has a high concentration of total phenolic content of 489.5–148.3 mg.GAE/100 g, total anthocyanin content of 124.9–260.1 mg.CE/100 g, and total flavonoid content of 12.7–26.0 mg.QE/100 g. The results of free radical scavenging activity (1.26–4.91 μg/mL, as EC50) and ferric reducing antioxidant power (82.93–184.10 μmol/g of skin as equivalent to Fe2SO4) indicate high antioxidant activity, independently of the drying process applied. It was concluded that, if the application is directed to anthocyanin compounds, the use of lyophilization is recommended. On the other hand, if the interest is in bioactive compounds that exert antioxidant activity, conventional oven-drying can be used.

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Section: Resultsmentioning

confidence: 99%

Effect of Drying Methods on Bioactive Compounds and Antioxidant Capacity in Grape Skin Residues from the New Hybrid Variety “BRS Magna”

et al. 2020

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“…These results are of great interest, since they guarantee that the enrichment of VOOs or other nourishment with the VOO extract may be a good tool for the industrial preparation of functional foods that can be used as co-adjuvants for the prevention or treatment of chronic diseases such as cardiovascular, cancer, and other age-related diseases. Epidemiological evidence suggest that the phenols found in olive oil have anticancer properties and may play an important role in reducing inflammation, free radicals, and carcinogenesis as well as may improve the gut microbiota composition [17,18]. In addition, Borzi et al [19] point out that olive oil polyphenols exert a protective effect against colorectal cancer.…”

Section: Discussionmentioning

confidence: 99%

Acute/Subacute and Sub-Chronic Oral Toxicity of a Hidroxytyrosol-Rich Virgin Olive Oil Extract

et al. 2019

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The objective of this study was to determine the acute (one single dose), subacute (14 days), and sub-chronic (90 days) toxicity of an aqueous virgin olive oil (VOO) extract rich in hydroxytyrosol in rats. For acute/subacute toxicity, rats were divided into three groups. The control group received distilled water (n = 9), another experimental group received a single dose of 300 mg/kg (n = 3), and a third group received one dose of 2000 mg/kg (n = 4) during 14 days. The sub-chronic study included 60rats distributed in three groups (n = 20: 10 males and 10 females) receiving daily different three doses of the VOO extract in the drinking water during 90 days: (1) 100 mg/kg, (2) 300 mg/kg, and (3) 1000 mg/kg. In parallel, a fourth additional group (n = 20: 10 males and 10 females) did not receive any extract (control group). Clinical signs, body weight, functional observations of sensory and motor reactivity, hematological and biochemical analyses, and macroscopic and microscopic histopathology were evaluated. No adverse effects were observed after the administration of the different doses of the hydroxytyrosol-rich VOO extract, which suggests that the enrichment of VOO in its phenolic compound is safe, and can be used as functional foods for the treatment of chronic degenerative diseases.

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“…Also the role of artificial sweeteners, probiotics and emulsifiers could be evaluated if estimates of these levels were included in the data collection [101,[113][114][115]. Finally, as some dietary compounds have been shown to influence the epigenome, inflammation and microbiota [116][117][118][119], it could be enlightening to include estimated levels of such compounds, e.g. resveratrol and quercetin, and some of their putative molecular targets, such as HDACs and NFkappaB, into the data [29] to begin to elucidate a more unified picture of the influence of diet.…”

Section: Discussionmentioning

confidence: 99%

An integrative machine learning approach to discovering multi-level molecular mechanisms of obesity using data from monozygotic twin pairs

et al. 2020

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We combined clinical, cytokine, genomic, methylation and dietary data from 43 young adult monozygotic twin pairs (aged 22–36 years, 53% female), where 25 of the twin pairs were substantially weight discordant (delta body mass index > 3 kg m −2 ). These measurements were originally taken as part of the TwinFat study, a substudy of The Finnish Twin Cohort study. These five large multivariate datasets (comprising 42, 71, 1587, 1605 and 63 variables, respectively) were jointly analysed using an integrative machine learning method called group factor analysis (GFA) to offer new hypotheses into the multi-molecular-level interactions associated with the development of obesity. New potential links between cytokines and weight gain are identified, as well as associations between dietary, inflammatory and epigenetic factors. This encouraging case study aims to enthuse the research community to boldly attempt new machine learning approaches which have the potential to yield novel and unintuitive hypotheses. The source code of the GFA method is publically available as the R package GFA.

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Effects of Polyphenol-Rich Foods on Human Health

Cited by 84 publications

References 72 publications

Effect of Drying Methods on Bioactive Compounds and Antioxidant Capacity in Grape Skin Residues from the New Hybrid Variety “BRS Magna”

Effect of Drying Methods on Bioactive Compounds and Antioxidant Capacity in Grape Skin Residues from the New Hybrid Variety “BRS Magna”

Acute/Subacute and Sub-Chronic Oral Toxicity of a Hidroxytyrosol-Rich Virgin Olive Oil Extract

An integrative machine learning approach to discovering multi-level molecular mechanisms of obesity using data from monozygotic twin pairs

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