The effect of isokinetic and aerobic exercises on serum interleukin-6 and tumor necrosis factor alpha levels, pain, and functional activity in patients with knee osteoarthritis

Samut, Gülbüz; Dinçer, Fitnat; Özdemir, Oya

doi:10.3109/14397595.2015.1038425

Cited by 33 publications

(25 citation statements)

References 26 publications

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“…One study showed only the age range, which was from 41 to 63 years and 1 study included only those with a BMI <35 . One study included participants at risk of OA (i.e., no radiographic signs of OA, sedentary behavior, age >60 years, and a BMI >27) , and the remaining 11 studies included participants with or without pain but with radiographic knee OA, ranging from Kellgren/Lawrence (K/L) grades 1 to 4 (Table ).…”

Section: Resultsmentioning

confidence: 99%

“…The types of exercise therapy interventions used were strengthening exercise in 5 studies , aerobic exercise in 3 studies , and a combination of strengthening and aerobic exercise in 5 studies (Table ). Biomarker samples were obtained at 4 to 24 weeks following the exercise therapy intervention in all the studies.…”

Section: Resultsmentioning

confidence: 99%

“…Of the 12 biomarker studies, 5 investigated markers of inflammation , 2 investigated cytokine receptors , 1 investigated proteases , 3 investigated turnover of collagens , 4 investigated glycoproteins , and 5 investigated glycosaminoglycans (Table ). Some studies investigated >1 molecular biomarker.…”

Section: Resultsmentioning

confidence: 99%

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Impact of Exercise Therapy on Molecular Biomarkers Related to Cartilage and Inflammation in Individuals at Risk of, or With Established, Knee Osteoarthritis: A Systematic Review and Meta‐Analysis of Randomized Controlled Trials

Struglics

Larsson

Steultjens

et al. 2019

Arthritis Care & Research

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Objective. To investigate the impact of exercise therapy on molecular biomarkers related to cartilage and inflammation in individuals at risk of, or with established, knee osteoarthritis by conducting a systematic review of randomized controlled trials (RCTs).Methods. We conducted a literature search up to September 2017 in 5 major databases with no restriction on publication year or language. Data were extracted from the first available follow-up time point, and we performed a narrative synthesis for the effect of exercise therapy on molecular biomarkers related to cartilage and inflammation. A subset of studies reporting sufficient data was combined in a meta-analysis, using an adjusted random-effects model.Results. Twelve RCTs involving 57 study comparisons at 4 to 24 weeks following an exercise-therapy intervention were included. Exercise therapy decreased molecular biomarkers in 17 study comparisons (30%), had no effect in 36 (63%), and increased molecular biomarkers in 4 study comparisons (7%). Meta-analyses of 9 biomarkers showed that exercise therapy was associated with nonsignificant reductions of the C-reactive protein level, Cterminal crosslinking telopeptide of type II collagen, tumor necrosis factor (TNF), soluble TNF receptors 1 and 2, C2C neoepitope of type II collagen, and cartilage oligomeric matrix protein, compared to nonexercising control groups, and exercise therapy had no effect on interleukin-6 and soluble interleukin-6 receptor.Conclusion. Exercise therapy is not harmful, because it does not increase the concentration of molecular biomarkers related to cartilage turnover and inflammation, implicated in osteoarthritis progression. The overall quality of evidence was downgraded to low because of the limited number of RCTs available.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Impact of Exercise Therapy on Molecular Biomarkers Related to Cartilage and Inflammation in Individuals at Risk of, or With Established, Knee Osteoarthritis: A Systematic Review and Meta‐Analysis of Randomized Controlled Trials

Struglics

Larsson

Steultjens

et al. 2019

Arthritis Care & Research

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“…According to Gomes et al 16 , aerobic exercise (walking training, three times/week for 12 weeks) was effective in decreasing the levels of soluble receptor for tumor necrosis factor (sTNFR2) from plasma, which has been associated with reduced inflammation in articular cartilage damage and improved physical function in OA patients 16 . Moreover, Samut et al 17 , found that aerobic exercise (walking training, 3 days/week for 6 weeks) decreased pain and increased functional capacity and muscle strength in patients with knee OA.…”

Section: Introductionmentioning

confidence: 99%

Aerobic exercise training and low-level laser therapy modulate inflammatory response and degenerative process in an experimental model of knee osteoarthritis in rats

Assis

Milares

Almeida

et al. 2016

Osteoarthritis and Cartilage

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“…There are several studies showing that isokinetic muscle strengthening exercises improve proprioception, balance and physical function. [8][9][10][11][12][13][14] In this study, we aimed to assess the effect of quadriceps and hamstring strengthening on proprioception, balance, and physical function specifically in patients with Grade 2 or 3 knee OA, according to the Kellgren-Lawrence (KL) radiographic grading system and moderate risk of fall.…”

mentioning

confidence: 99%

Effects of isokinetic muscle strengthening on balance, proprioception, and physical function in bilateral knee osteoarthritis patients with moderate fall risk

Gezgınaslan

Öztürk

Cengiz

et al. 2018

Turk J Phys Med Rehab

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Objectives: This study aims to assess the effects of isokinetic quadriceps and hamstring strengthening exercises on balance, proprioception, and physical function in patients with moderate-to-severe knee osteoarthritis and moderate fall risk. Patients and methods: Between November 2011 and December 2012, a total of 39 participants (30 females, 9 males; mean age 61.7±8.6 years; range, 18 to 79 years) with Grade 2 or 3 knee osteoarthritis according to the Kellgren-Lawrence radiographic grading system and moderate risk of fall with active knee pain were included in this study. All participants received isokinetic quadriceps and hamstring strengthening exercises for six weeks. Pre-treatment quadriceps and hamstring muscle strength (peak torque and total work value) and quadriceps to hamstring muscle strength ratio at angular velocities of 60°/sec and 180°/sec, range of motion (ROM), average proprioceptive errors at 15-45° and 30-60°, the Berg Balance Scale (BBS) scores, the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) subscale scores, the Visual Analog Scale (VAS) scores, and physical function tests results were compared with the post-treatment results. The correlations of pre-and post-treatment BBS and average proprioceptive error at 15-45° and 30-60° changes to other pre-and post-treatment clinical measurements changes were calculated. Results: Post-treatment quadriceps and hamstring muscle strength at angular velocities of 60°/sec and 180°/sec and quadriceps to hamstring muscle strength ratios at angular velocity of 60°/sec, ROM, average proprioceptive errors at 15-45° and 30-60°, BBS scores, WOMAC subscale scores, VAS scores, and physical function tests significantly improved compared to the pre-treatment results (p<0.001). Statistically significant correlations were found between the pre-and post-treatment BBS score changes and pre-and post-treatment VAS (p=0.015), WOMAC-Pain (p=0.017), WOMAC-Physical Function (p=0.005) scores and Timed Up and Go Test (p=0.036) scores. Conclusion: Inclusion of isokinetic quadriceps and hamstring strengthening exercises into the rehabilitation programs for the patients with knee osteoarthritis may improve the quality of life and contribute to the decreased risk of fall.

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The effect of isokinetic and aerobic exercises on serum interleukin-6 and tumor necrosis factor alpha levels, pain, and functional activity in patients with knee osteoarthritis

Cited by 33 publications

References 26 publications

Impact of Exercise Therapy on Molecular Biomarkers Related to Cartilage and Inflammation in Individuals at Risk of, or With Established, Knee Osteoarthritis: A Systematic Review and Meta‐Analysis of Randomized Controlled Trials

Impact of Exercise Therapy on Molecular Biomarkers Related to Cartilage and Inflammation in Individuals at Risk of, or With Established, Knee Osteoarthritis: A Systematic Review and Meta‐Analysis of Randomized Controlled Trials

Aerobic exercise training and low-level laser therapy modulate inflammatory response and degenerative process in an experimental model of knee osteoarthritis in rats

Effects of isokinetic muscle strengthening on balance, proprioception, and physical function in bilateral knee osteoarthritis patients with moderate fall risk

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