These results suggest that exercise training and LLLT were effective in preventing cartilage degeneration and modulating inflammatory process induced by knee OA.
These results suggest that aquatic exercise program and LLLT were effective in preventing cartilage degeneration. Also, physical exercise program presented anti-inflammatory effects in the knees in OA rats.
The aim of this study was to analyze the effects of low-level laser therapy (LLLT) on the prevention of cartilage damage after the anterior cruciate ligament transection (ACLT) in knees of rats. Thirty male rats (Wistar) were distributed into three groups (n = 10 each): injured control group (CG); injured laser-treated group at 10 J/cm(2) (L10), and injured laser-treated group at 50 J/cm(2) (L50). Laser treatment started immediately after the surgery and it was performed for 15 sessions. An 808 nm laser, at 10 and 50 J/cm(2), was used. To evaluate the effects of LLLT, the qualitative and semi-quantitative histological, morphometric, and immunohistochemistry analysis were performed. Initial signs of tissue degradation were observed in CG. Interestingly, laser-treated animals presented a better tissue organization, especially at the fluence of 10 J/cm(2). Furthermore, laser phototherapy was able of modulating some of the aspects related to the degenerative process, such as the prevention of proteoglycans loss and the increase in cartilage area. However, LLLT was not able of modulating chondrocytes proliferation and the immunoexpression of markers related to inflammatory process (IL-1 and MMP-13). This study showed that 808 nm laser, at both fluences, prevented features related to the articular degenerative process in the knees of rats after ACLT.
These results suggest that exercise training and low-level laser therapy were effective in preventing musculoskeletal alterations related to atrophy caused by the degenerative process induced by knee OA.
Diabetes melito é um grupo de desordens metabólicas, com uma característica em comum, a hiperglicemia, causando feridas e uma anormal cicatrização. A eletroestimulação é eficaz neste tratamento, ativando macrófago, fibroblasto e colágeno, além de ter ação vasodilatadora capilar. O objetivo deste trabalho foi verificar os efeitos do ultrassom associado à insulina no processo de cicatrização de animais diabéticos induzidos. Foram utilizadas 20 ratas fêmeas adultas da linhagem Wistar induzidas à diabetes por injeção endovenosa de aloxana (Dioxiuracio monohidrato). Os animais foram divididos em: Grupo Controle (GC) e Grupo Experimental (GE), os grupos sofreram uma lesão no músculo tibial anterior da pata traseira direita. Após a lesão, o GC recebeu o tratamento conservador, somente de gel carbopol, e o GE recebeu tratamento de gel de carbopol com insulina em fonoforese. O protocolo consistiu de ultrassom de cabeçote reduzido com área efetiva de radiação (ERA) de 0,6 cm² com intensidade de 0,4 W/cm², frequência de 1 Mhz, modo contínuo e aplicação de um minuto, durante 5 sessões. Conclui-se, portanto, que a insulina associada à fonoforese atua na redução das agressões teciduais causadas por atividade oxidativa excessiva, gerada na resposta inflamatória.Palavras-chave: insulina, fonoforese, cicatrização, diabetes.
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