The effect of irradiation on human lymphocytes

Humble, J. G.; Jayne, W. H. W.; Pulvertaft, R. J. V.; Wilson, C. W.

doi:10.1016/s0368-2242(54)80011-x

Cited by 10 publications

(2 citation statements)

References 9 publications

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“…Regarding irradiation of lymphocytes with small doses of ionizing ra diation, this has been shown to have a cytocidal effect [18][19][20]. The ra diosensitivity of the circulating lymphocyte which is in a non-dividing state is of great interest in radiobiology.…”

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confidence: 99%

Surface Molecular Components of Human Lymphocytes

Mehrishi¹

1972

Int Arch Allergy Immunol

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The presence of at least 5 different types of ionizable groups on the surface of normal human lymphocytes on a per-cell-basis has been established. Two possible arrangements of these groups have been put forward. These surface groups (positively and negatively charged) may provide a molecular basis for establishing differences, if any, between types of lymphocytes. The complex reactions taking place on the surface of lymphocytes involved in immune processes are of considerable interest in health and disease.

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Surface Molecular Components of Human Lymphocytes

Mehrishi¹

1972

Int Arch Allergy Immunol

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“…Humble et al (18) reported that the effects on lymphocytes of therapeutic irradiation on humans "are produced by destructioil or modificatioil of the structure producing lymphoid cells".…”

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confidence: 99%

Behavior and Function of Lymphocytes in Relation to Their Basic Nuclear Units

Engelbert¹

1956

Can. J. Zool.

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.I his paper records a discovery of basic, pa;tially independent nuclear units that lie within a common nuclear ~nernbrane of some vertebrate cells. The cells concerned are found in series from small (1-2 p) to large (10-15 p or more). The smallest cells possess one basic nuclear unit, the larger cells have several. The series of cells fro~n small to large represent stages of a life cycle. Certain of the basic nuclear units act as reproductive organelles and certain large cells are parent cells producing new small cells thus closing one life cycle and startlng another. 'I'he large cells are forrncd from the small cells through a series of fusions. 'I'he basic nuclear units behave similarly to ruicron~~clci, the reproductive organelles in ciliates, but the fusions of the vertebrate cells are permanent, not temporary unions such as conjugation in ciliates.The discovery of the basic nuclear units and their role in the lile cycle of some vertebrate cells has given rise to a new concept of blood cell cytogenesis. The inclivitlual chromatin lumps characteristic of the nuclei of lymphocytes are founcl to be separate entities, the basic nuclear units upon which bloocl cell cytogenesis depends.The small Ij,mphocyte (4-6p) is found to be the ltey cell in reproductio~i of bloocl cells. Two small lymphocytes move together and establish close contact. The contact becomes permanent as a projection of nucleoplasin that extends out from each of them joins forming an internuclear bridge. As soon as contact is made between the two cells their basic iluclear ini its begin a series of divisions that increase the number of units but decrease their incliviclual sizes. These clivisions eventually leacl to formation of nexv cells.

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Molecular aspects of the mammalian cell surface

Mehrishi

1972

Progress in Biophysics and Molecular Biology

138

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The effect of irradiation on human lymphocytes

Cited by 10 publications

References 9 publications

Surface Molecular Components of Human Lymphocytes

Surface Molecular Components of Human Lymphocytes

Behavior and Function of Lymphocytes in Relation to Their Basic Nuclear Units

Molecular aspects of the mammalian cell surface

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