The effect of iron-deficiency anaemia on two indices of nutritional status, prealbumin and transferrin

Delpeuch, Francis; Cornu, A.; Chevalier, Philippe

doi:10.1079/bjn19800100

Cited by 29 publications

(10 citation statements)

References 15 publications

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“…2. This suggests that the concentration of Tf increases in cases of low SFe concentration, in accordance with DELPEUCH et al (1980). Plasma Tf concentration before slaughter was similar in calves fed 20 mg Fe./kg MR as in another experiment with calves fed only 10 mg Fe/kg MR and developing severe Fe deficiency anaemia (Tf: 5.4 2 0.4 g/l; SFe: 5.2 5 0.9 pmol A; H b : 59 2 2 g/l; CEPPI and BLUM, unpublished observations).…”

Section: Discussionsupporting

confidence: 70%

Iron Status, Erythropoiesis, Meat Colour, Health Status and Growth Performance of Veal Calves Held on and Fed Straw

Moser

Bruckmaier

Blum

1994

Journal of Veterinary Medicine Series A

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Summary Two experiments were designed to study the iron (Fe) status in veal calves (62 intact males) fed and held on straw. In experiment 1, two groups were fed 20 mg Fe/kg milk replacer (MR) and held unattached on rye or barley straw litter. In experiment 2, groups were fed 20 mg Fe/kg MR and held unattached on rye straw litter or on sawdust or attached on wooden slatted floors without straw litter or were fed 50 mg Fe/kg MR and held unattached on sawdust. Fe concentrations in tested straw sorts (rye, barley, wheat, triticale) were similar and ranged from 15 to 85 mg Fe/kg dry matter. Growth performance and health status were not significantly influenced by Fe intake through MR or straw. Straw intake in the group fed straw was greater (P < 0.01) at the end than at the start of the growth period, but intake of different straw sorts was similar. Calves fed 20, but not those fed 50 mg Fe/kg MR, developed marked hypoferraemia, but only moderate anaemia. Total iron binding capacity (TIBC) was significantly (P < 0.05) and transferrin (Tf) concentration was numerically higher in calves fed 20 than in those fed 50 mg Fe/kg MR on slaughter day. TIBC and Tf were positively correlated (r = 0.63). Haemin concentration and lightness of m. rectus abdominis were significantly (P < 0.01), whereas myoglobin concentration was numerically greater in calves fed 50 than in those fed 20 mg Fe/kg MR. In conclusion, haematological and blood chemical parameters and meat colour were influenced only by high Fe intake through MR, but not if calves were held on straw litter or were fed straw.

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Section: Discussionsupporting

confidence: 70%

Iron Status, Erythropoiesis, Meat Colour, Health Status and Growth Performance of Veal Calves Held on and Fed Straw

Moser

Bruckmaier

Blum

1994

Journal of Veterinary Medicine Series A

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“…The assessment of nutritional status is essential for a diagnosis of nutritional compromise, and measurements of serum concentrations of RTPs such as RBP, PA and TF have been reported to be more accurate for this assessment in comparison to albumin (37)(38)(39). The serum concentration of galectin-3 showed a significant inverse correlation with assessed RTPs.…”

Section: Discussionmentioning

confidence: 66%

Association between circulating galectin-3 levels and the immunological, inflammatory and nutritional parameters in patients with colorectal cancer

et al. 2016

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“…Besides these encouraging results, other studies have noted that the value of albumin, transferrin or transthyretin concentration as a measure of nutritional status was limited because of the complex relationships between these transport proteins and other biochemical markers such as acutephase reactants (Ingenbleek et al, 1975;Wade et al, 1988;Ingenbleek and Carpentier, 1985) and iron (Delpeuch et al, 1980;Keusch and Farthing, 1986). Transport proteins synthesis is reduced in both malnutrition and infection, but infection reduces free iron concentration causing an adaptive increase of the transferrin level.…”

Section: Discussionmentioning

confidence: 99%

“…In Senegal the team headed by Ingenbleek et al (1975) has established the clinical signi®cance of the thyroid-binding prealbumin (transthyretin) in a group of 37 malnourished children. A few years later, Ogunshima and Hussain (1980) have concluded from their study of 88 Nigerian pre-school children that transthyretin was the only parameter studied able to distinguish mild malnutrition from normal nutritional status.Besides these encouraging results, other studies have noted that the value of albumin, transferrin or transthyretin concentration as a measure of nutritional status was limited because of the complex relationships between these transport proteins and other biochemical markers such as acutephase reactants (Ingenbleek et al, 1975;Wade et al, 1988;Ingenbleek and Carpentier, 1985) and iron (Delpeuch et al, 1980;Keusch and Farthing, 1986). Transport proteins synthesis is reduced in both malnutrition and infection, but infection reduces free iron concentration causing an adaptive increase of the transferrin level.…”

mentioning

confidence: 99%

Weakness of biochemical markers of nutritional and inflammatory status as prognostic indices for growth retardation and morbidity of young children in central Africa

Tonglet

Lembo

Dramaix³

et al. 1997

Eur J Clin Nutr

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Objective:To determine to what extent biochemical markers of the nutritional and in¯ammatory status of young children are related to subsequent growth retardation and morbidity. Design: Population-based follow-up study of a cohort of children from admission to ®nal survey round six months later. Setting: Health area in Northern Kivu, Zaire. Subjects: 842 children under two years of age of whom about one-third gave informed consent to capillary blood collection. Main outcome measures: Concentration of albumin, transferrin, transthyretin, a 1 -acid glycoprotein, C-reactive protein, and complement component C3 at baseline, and three and six months later. Incremental growth per 1 month, 3 months and 6 months of follow-up. Cumulative incidence of disease per 1 month and 3 months interval. Results: A high proportion of children was with low concentrations of transport proteins and high concentrations of acute-phase reactants. Weight growth and arm circumference growth did not vary signi®cantly with respect to initial concentrations of biomarkers, but subsequent height growth was lower in children with high values of transferrin, a 1 -acid glycoprotein, and complement component C3 at baseline. Cumulative incidence of malaria, respiratory illness, and diarrhoea was not signi®cantly affected by the concentration of the biomarkers at baseline. Conclusions: In this part of central Africa performing biochemical measurements should not be encouraged as a means for risk scoring in non-hospitalized children. Sponsorship: This research has been carried out on behalf of the Centre Scienti®que et Me Âdical de l'Universite Â Libre de Bruxelles pour ses Activite Âs de Coope Âration, which is a non-pro®t organization supported by the Belgian Agency for International Development, and by the European Commission. This work was supported in part by grants from the Fondation Universitaire David et Alice Van Buuren, the Fonds National de la Recherche Scienti®que et Me Âdicale (Contract 3.4526.90.F), the UNICEF representative in Zaire, and the SANRU Basic Rural Health Project (Project 660-0107 USAID, DSP, ECZ). Descriptors: biochemical markers; growth; morbidity; child; Africa; Zaire IntroductionIn developing countries, many attempts have been made over the last three decades to ®nd early and sensitive indicators of severity and prognosis of protein-energy malnutrition. For that purpose, several clinical, anthropometric, and biochemical measurements have been proposed, re¯ecting alterations related to either malnutrition or infection, as well as their outcomes (Waterlow, 1992). Studies by McLaren, Pellett and Read (1967) in Jordan, and Whitehead, Frood and Poskitt (1971) in Uganda, played a seminal part in stimulating interest in the identi®cation of biochemical markers as means for risk scoring in the ®eld. Since then, a large body of literature has documented the clinical signi®cance and the complex relationships of a number of readily available blood markers of the nutritional status and the phlogistic reaction. These included transpo...

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The effect of iron-deficiency anaemia on two indices of nutritional status, prealbumin and transferrin

Abstract: On the contrary, prealbumin seems to be more useful.

Cited by 29 publications

References 15 publications

Iron Status, Erythropoiesis, Meat Colour, Health Status and Growth Performance of Veal Calves Held on and Fed Straw

Iron Status, Erythropoiesis, Meat Colour, Health Status and Growth Performance of Veal Calves Held on and Fed Straw

Association between circulating galectin-3 levels and the immunological, inflammatory and nutritional parameters in patients with colorectal cancer

Weakness of biochemical markers of nutritional and inflammatory status as prognostic indices for growth retardation and morbidity of young children in central Africa

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