The effect of iodopovidone versus bleomycin in chemical pleurodesis

Abstract

Background Malignant pleural effusion continues to be a common problem in patients with metastatic disease. This study was conducted to compare the efficacy and safety of bleomycin pleurodesis with povidone-iodine pleurodesis through a chest drain as palliative treatment for recurrent malignant pleural effusion. Methods Sixty cancer patients (36 males and 24 females) with recurrent malignant pleural effusion were enrolled in a prospective randomized trial. Thirty patients received povidone-iodine pleurodesis and 30 received bleomycin pleurodesis. Age, sex, side of the primary pathology, treatment outcome (recurrence and relapse time), and complications were analyzed. Results The mean age was 59.63 ± 7.68 years in the povidone-iodine group and 57.97 ± 9.27 years in the bleomycin group ( p = 0.452). The complications were identical in both groups: 2 (6.7%) patients had chest pain, 2 (6.7%) had fever, and one (3.3%) had hypotension. There was a good response to therapy in 20 (66.7%) patients in the bleomycin group and 25 (83.3%) in the povidone-iodine group ( p = 0.136). Conclusion The results of this study indicate that povidone-iodine should be considered as a selective chemical agent to perform pleurodesis in patients with recurrent malignant pleural effusion because it has the same effect but costs less than bleomycin.

Current state of palliative care in iran and related issues: A narrative review

“…The important components and findings of final included articles are presented in Table 2 . Results of the study showed that included studies had a focus on different patients/participants including cancer,[ 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 ] hemodialysis,[ 45 ] heart failure,[ 46 47 ] chronic disease,[ 48 ] chronic pain,[ 49 ] and with anonymous groups. [ 50 51 52 53 54 55 ] Several provinces/cities were engaged in the studies including Tehran,[ 12 13 14 15 17 20 21 24 25 26 29 30 31 32 33 34 35 37 39 40 41 42 43 48 , 51 , 52 Isfahan,[ 22 27 28 …”

“…[ 50 51 52 53 54 55 ] Several provinces/cities were engaged in the studies including Tehran,[ 12 13 14 15 17 20 21 24 25 26 29 30 31 32 33 34 35 37 39 40 41 42 43 48 , 51 , 52 Isfahan,[ 22 27 28 38 55 ] Kerman,[ 45 53 ] Tabriz,[ 16 36 ] Mashhad,[ 18 19 ] Yasouj,[ 44 ] Gorgan,[ 49 ] Neyshabour,[ 50 ] Jiroft,[ 46 47 ] Meybod/Ardakan,[ 54 ] Gorgan/Gonabad. [ 23 ] Majority of studies had quantitative approach, including interventional,[ 17 18 19 22 23 29 31 33 35 44 47 49 54 ] descriptive,[ 20 39 41 42 50 53 ] and correlational-analytical. [ 37 45 46 51 ] This was then followed by qualitative[ 12…”

“…[ 37 45 46 51 ] This was then followed by qualitative[ 12 13 14 15 16 21 24 25 26 27 30 32 34 36 40 43 48 52 ] and mixed methods. [ 28 38 55 ] In quantitative interventional PC studies, a range of medical-surgical,[ 17 18 19 23 29 31 33 37 ] educational,[ 44 49 54 ] and psycho-spiritual[ 22 35 ] managements were used as an independent variable.…”

Linfangiomatosis Kaposiforme: Reporte de un Caso y Revisión de la Literatura

“…Cuando la LK se localizada a nivel torácico, se puede considerar la indicación de un acceso quirúrgico (idealmente por videotoracoscopía), especialmente si existen síntomas de ocupación pleural (Luisi et al;Ozeki et al, 2019a). Para reducir el derrame pleural recurrente, esta indicado la pleurectomía parietal, ligadura del conducto torácico o la pleurodesis con 15 a 120 U de bleomicina intracavitario diluida en 100 cc de solusión salina y removida 6 a 24 horas después (Bagheri et al, 2018).…”

Povidone-iodine chemical pleurodesis in treating spontaneous chylothorax in pediatric patients

“…In these studies, it was highlighted that the incidence of chest pain after CP was as high as 55% and 31% respectively, and attention should be paid to possible allergic reactions, cardiopulmonary insufficiency, thyrotoxicosis, nephrotoxicity, and visual impairment. However, other studies have shown that the above adverse reactions are usually rare, as long as the dosage, concentration, and time of PI are well controlled to avoid excessive absorption by the pleura during the treatment process (18).…”