The Effect of Intravenous Selenium on Oxidative Stress in Critically Ill Patients with Acute Respiratory Distress Syndrome

Mahmoodpoor, Ata; Hamishehkar, Hadi; Shadvar, Kamran; Ostadi, Zohreh; Sanaie, Sarvin; Saghaleini, Seied Hadi; Nader, Nader D.

doi:10.1080/08820139.2018.1496098

Cited by 79 publications

(77 citation statements)

References 33 publications

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“…Serum concentrations of IL-1β and IL-6 were inversely associated with serum Se concentrations. Nevertheless, there was no effect on overall survival, mechanical ventilation time, and length of stay in intensive care (176). In LPS-stressed RAW264.7 cells, LPS increased mRNA profiles of inflammatory genes, while short-time Se pretreatment reduced the LPS-induced upregulation of cyclooxygenase-2, intercellular adhesion molecule−1, IL-1β, IL-6, IL-10, nitric oxide synthase, and monocyte chemoattractant protein-1 and further increased expression of IFN-β and TNF-α (177).…”

Section: Seleniummentioning

confidence: 86%

Clinical Impact Potential of Supplemental Nutrients as Adjuncts of Therapy in High-Risk COVID-19 for Obese Patients

Şahin

Orhan

Uckun³

et al. 2020

Front. Nutr.

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The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) disease (COVID-19) in China at the end of 2019 caused a major global pandemic and continues to be an unresolved global health crisis. The supportive care interventions for reducing the severity of symptoms along with participation in clinical trials of investigational treatments are the mainstay of COVID-19 management because there is no effective standard therapy for COVID-19. The comorbidity of COVID-19 rises in obese patients. Micronutrients may boost the host immunity against viral infections, including COVID-19. In this review, we discuss the clinical impact potential of supplemental nutrients as adjuncts of therapy in high-risk COVID-19 for obese patients.

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Section: Seleniummentioning

confidence: 86%

Clinical Impact Potential of Supplemental Nutrients as Adjuncts of Therapy in High-Risk COVID-19 for Obese Patients

Şahin

Orhan

Uckun³

et al. 2020

Front. Nutr.

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“…Similarly, integrated-omics analyses of pathways affected by the selenium status in rectal biopsies from 22 healthy adults showed reduced inflammatory and immune responses and cytoskeleton remodeling in the suboptimal selenium status group [ 95 ]. Similarly, selenium supplementation was shown to modulate the inflammatory response in respiratory distress syndrome patients by restoring the antioxidant capacity of the lungs, which moderated the inflammatory responses through interleukin (IL)-1β and IL-6 levels and meaningfully improved the respiratory mechanics [ 96 ].…”

Section: Selenium and Immunobiologymentioning

confidence: 99%

Selenium, Selenoproteins, and Immunity

2018

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Selenium is an essential micronutrient that plays a crucial role in development and a wide variety of physiological processes including effect immune responses. The immune system relies on adequate dietary selenium intake and this nutrient exerts its biological effects mostly through its incorporation into selenoproteins. The selenoproteome contains 25 members in humans that exhibit a wide variety of functions. The development of high-throughput omic approaches and novel bioinformatics tools has led to new insights regarding the effects of selenium and selenoproteins in human immuno-biology. Equally important are the innovative experimental systems that have emerged to interrogate molecular mechanisms underlying those effects. This review presents a summary of the current understanding of the role of selenium and selenoproteins in regulating immune cell functions and how dysregulation of these processes may lead to inflammation or immune-related diseases.

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“…38,39 This category (gray boxes) also includes interventions with indeterminate results, such as the case for positive end-expiratory pressure (PEEP) 15 -itself is a component of lung-protective ventilation, but the appropriate amount to use is still contended-or those that have value in ARDS patients aside from improving ARDS outcomes, such as early trophic enteral nutrition to prevent gastric intolerance 40 and extracorporeal membrane oxygenation as a rescue therapy. 35,36 In orange boxes are interventions that failed to demonstrate improvements in ARDS outcomes, such as antifungals, lisofylline, albuterol, simvastatin, vitamin C, and vitamin D. [41][42][43][44][45][46][47]76,77 Dexamethasone is also listed in this category given that the DEXA-ARDS trial was conducted in an unblinded fashion 28 and previous randomized trials showed no clinical efficacy for steroid administration in ARDS. Methylprednisolone, 27 rosuvastatin, 49 and omega-3 fatty acids, 48 listed in red boxes, have been shown to cause potential harm in randomized controlled trials.…”

Section: Prone Positioningmentioning

confidence: 99%

Acute Respiratory Distress Syndrome

et al. 2020

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A cute respiratory distress syndrome (ARDS) is defined as hypoxemia secondary to a rapid onset of noncardiogenic pulmonary edema. 1 Etiologic risk factors for ARDS encompass both direct and indirect lung injuries including but not limited to pneumonia, sepsis, noncardiogenic shock, aspiration, trauma, contusion, transfusion, and inhalation injuries. Although clinical recognition and management of ARDS have improved significantly over the past 25 yr, it is still a leading cause of death in critically ill patients, with mortality rates consistently reported around 30 to 40%. 2 An important factor in the high mortality rate in ARDS is that treatment is mainly focused on clinical management and no targeted therapies currently exist. Furthermore, ARDS management is often challenging as it commonly occurs in a clinical setting of multiple organ failure and can also lead to the development of nonpulmonary organ injury, such as acute kidney injury. 3 Recently, the pandemic caused by coronavirus disease 2019 (COVID-19), which results from infection by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), has led to a dramatic incidence in COVID-19-related ARDS. Thirty to forty percent of COVID-19 hospitalized patients develop ARDS, and it is associated with 70% of fatal cases. 4,5 At the time of this writing (July 31, 2020), there are more than 4.5 million COVID-19 cases and 152,000 related deaths in the United States. 6 Here, we describe select management strategies that have become foundations of ARDS clinical management and provide an update of emerging approaches for the treatment of ARDS related to COVID-19.

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The Effect of Intravenous Selenium on Oxidative Stress in Critically Ill Patients with Acute Respiratory Distress Syndrome

Cited by 79 publications

References 33 publications

Clinical Impact Potential of Supplemental Nutrients as Adjuncts of Therapy in High-Risk COVID-19 for Obese Patients

Clinical Impact Potential of Supplemental Nutrients as Adjuncts of Therapy in High-Risk COVID-19 for Obese Patients

Selenium, Selenoproteins, and Immunity

Acute Respiratory Distress Syndrome

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