The effect of intraarterial high-dose cisplatin on lymph nodes in oral and oropharyngeal cancer

Kovács, A; Döbert, Natascha; Engels, Knut

doi:10.4103/0019-509x.102918

Cited by 5 publications

(3 citation statements)

References 21 publications

(26 reference statements)

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“…Shrinkage of enlarged lymph nodes, as observed by us, corroborate with other studies. [9] Similarly, subjective improvement in terms of alleviation of pain, reduction of salivation and drooling, decrease in foul odor and reduction of trismus was observed in our studies, similar to others. [10] Most patients showed regression of the tumor after a follow up of 6 months, thus indicating the effectiveness of the combination therapy.…”

Section: Discussionsupporting

confidence: 92%

Analytical study on the efficacy of neoadjuvant chemotherapy using a combination of methotrexate, bleomycin, and cisplatin in the management of advanced squamous cell carcinoma of the buccal mucosa

Kumar¹,

Biswas

Sarkar

et al. 2017

Indian J Med Paediatr Oncol

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Context:Cancers of the buccal mucosa (CaBM) predominate in India with late- stage diagnosis and poor survival, necessitating optimal management. Aim: Our study aimed at testing the efficacy of combination neoadjuvant chemotherapy (NACT) using cisplatin (CIS), bleomycin (BL) and methotrexate (MTX) for reducing tumour volume prior to surgery.Methodology:Patients with advanced CaBM (stage III, IV, n = 100) were administered 6 rounds of NACT with CIS, BL and MTX. Responses, toxicity and 6-month follow-up was monitored statistically to determine persistence of response.Results:A significant number of patients showed objective response as either complete or partial tumour regression with subjective response as reduced trismus, pain, salivation and foul odour. Moreover, there was mild associated toxicity and tumour regression continued in most patients even after 6-month follow-up.Conclusion:Our study indicates that NACT with CIS, BL and MTX offers a good therapeutic alternative in terms of significant objective and subjective responses, low toxicity, affordable costs and persistent responses.

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Section: Discussionsupporting

confidence: 92%

Analytical study on the efficacy of neoadjuvant chemotherapy using a combination of methotrexate, bleomycin, and cisplatin in the management of advanced squamous cell carcinoma of the buccal mucosa

Kumar¹,

Biswas

Sarkar

et al. 2017

Indian J Med Paediatr Oncol

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“…An i.a. bolus injection, usually applied with very high cisplatin dosages (100 mg/m 2 ), reaches high local concentrations during a brief infusion time of less than 1 min, which are decreased by thiosulfate (Robbins et al 2010; Kovacs et al 2012). An i.a.…”

Section: Introductionmentioning

confidence: 99%

“…Second, the exact technique of i.a. infusion is crucial for the outcome, and former studies have not always been optimal in terms of catheter position, concentration, and time of chemo exposure (Robbins et al 2010; Kovacs et al 2012; Rasch et al 2010). …”

Section: Introductionmentioning

confidence: 99%

Short-term intra-arterial infusion chemotherapy for head and neck cancer patients maintaining quality of life

Aigner

Selak

2018

J Cancer Res Clin Oncol

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PurposeHead and neck cancer treatment achieves good locoregional tumor control rates while causing severe side effects. Therapy with chemotherapeutic drugs administered intravenously is limited because either the concentrations at the tumor site are too low or the total dosages are too high. The evaluation of a technique for short-term intra-arterial infusion chemotherapy is described herein.MethodsIn a retrospective study, we reviewed the medical records of 97 patients with head and neck cancers who received short-term intra-arterial infusion chemotherapy (62 patients previously untreated, 35 patients with prior radiotherapy). All patients refused further radiotherapy. Response rates, overall survival and adverse effects were the study endpoints. The blood supply of the tumors was controlled with indigocarmine blue infusion and staining of the tumor region.ResultsComplete or partial response was found in 67%, 52% and 63% of previously untreated patients and in 25%, 30% and 29%, respectively, of previously irradiated patients for staging groups I–III, IVA and IVB/C. Patients with T3/T4 tumors who were previously irradiated showed a median overall survival of 9 months, and those without pretreatment showed a median overall survival of 22.5 months. None of the patients required tube feeding. No new case of dysphagia, xerostomia, or functional speech and hearing loss was reported. Pain and clinical symptoms were reduced for all patient groups. Indigocarmine staining showed reduced tumor blood supply in previously irradiated regions but good blood supply in untreated regions.ConclusionsShort-term intra-arterial infusion chemotherapy achieves promising response rates and lacks severe adverse effects.Electronic supplementary materialThe online version of this article (10.1007/s00432-018-2784-4) contains supplementary material, which is available to authorized users.

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Induction Chemotherapy in Head and Neck Cancers

Kovács¹

2016

Induction Chemotherapy

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The effect of intraarterial high-dose cisplatin on lymph nodes in oral and oropharyngeal cancer

Abstract: A regional effect of intraarterial cisplatin is proven. To date, it is not clear whether this is due to decreasing inflammatory reaction or a translymphatic anti-neoplastic effect.

Cited by 5 publications

References 21 publications

Analytical study on the efficacy of neoadjuvant chemotherapy using a combination of methotrexate, bleomycin, and cisplatin in the management of advanced squamous cell carcinoma of the buccal mucosa

Analytical study on the efficacy of neoadjuvant chemotherapy using a combination of methotrexate, bleomycin, and cisplatin in the management of advanced squamous cell carcinoma of the buccal mucosa

Short-term intra-arterial infusion chemotherapy for head and neck cancer patients maintaining quality of life

Induction Chemotherapy in Head and Neck Cancers

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