Analytical study on the efficacy of neoadjuvant chemotherapy using a combination of methotrexate, bleomycin, and cisplatin in the management of advanced squamous cell carcinoma of the buccal mucosa

Kumar, Santosh Manohar; Biswas, Srabani; Sarkar, Shreya; Mandal, Syam Sundar; Biswas, Jaydip

doi:10.4103/ijmpo.ijmpo_123_17

Cited by 2 publications

(2 citation statements)

References 9 publications

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“…Adriamycin, an orally administered DNA alkylating agent, has been the most potent chemotherapy applied in clinic, in addition to surgical excision. Bleomycin had been emerged as another vital chemotherapeutic agent in many types of cancer, including Hodgkin lymphoma ( 7 ), testicular cancer ( 8 ), and squamous-cell carcinoma ( 9 ). In the previous study, we firstly identified salinomycin as a novel identified cancer stem cells (CSCs) killer in gastric cancer cells ( 10 ).…”

Section: Introductionmentioning

confidence: 99%

Molecular Screening for Nigericin Treatment in Pancreatic Cancer by High-Throughput RNA Sequencing

Gao

Liu

et al. 2020

Front. Oncol.

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Objectives: Nigericin, an antibiotic derived from Streptomyces hygroscopicus, has been proved to exhibit promising anti-cancer effects on a variety of cancers. Our previous study investigated the potential anti-cancer properties in pancreatic cancer (PC), and demonstrated that nigericin could inhibit the cell viabilities in concentration-and time-dependent manners via differentially expressed circular RNAs (circRNAs). However, the knowledge of nigericin associated with long non-coding RNA (lncRNA) and mRNA in pancreatic cancer (PC) has not been studied. This study is to elucidate the underlying mechanism from the perspective of lncRNA and mRNA. Methods: The continuously varying molecules (lncRNAs and mRNAs) were comprehensively screened by high-throughput RNA sequencing. Results: Our data showed that 76 lncRNAs and 172 mRNAs were common differentially expressed in the nigericin anti-cancer process. Subsequently, the bioinformatics analyses, including Gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis, coding and non-coding co-expression network, cis-and trans-regulation predictions and protein-protein interaction (PPI) network, were applied to annotate the potential regulatory mechanisms among these coding and non-coding RNAs during the nigericin anti-cancer process. Conclusions: These findings provided new insight into the molecular mechanism of nigericin toward cancer cells, and suggested a possible clinical application in PC.

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Section: Introductionmentioning

confidence: 99%

Molecular Screening for Nigericin Treatment in Pancreatic Cancer by High-Throughput RNA Sequencing

Gao

Liu

et al. 2020

Front. Oncol.

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“…It is superior to single-agent with respect to response rate, duration of remission, and overall survival in patients with advanced and malignant urothelial carcinoma (4). Additionally, MTX/CPT is an effective regimen for patients with metastatic transitional cell carcinoma of the bladder and buccal mucosa (5,6). However, one of the primary concerns with the use of MTX/CPT is the possible development of toxicities including nephrotoxicity.…”

Section: Introductionmentioning

confidence: 99%

Melatonin and alpha lipoic acid attenuate methotrexate/ cisplatin-induced kidney toxicity in albino rats

2019

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Introduction: Most anticancer therapies are seldom effective by single anticancer drug due to biologic heterogeneity and multiple genetic alterations stimulating the use of anticancer drug combinations. Methotrexate/cisplatin (MTX/CPT) has shown beneficial effects in the treatment of metastatic and malignant tumors, but its use may perturb kidney function. Objectives: The present study assessed the protective effects of melatonin (MT) and alpha-lipoic acid (ALA) against kidney toxicity induced by MTX/CPT in albino rats. Materials and Methods: Forty-eight adult male albino rats were randomized into groups and pretreated with MT (10 mg/kg), ALA (10 mg/kg) and MT+ALA daily for five days before treatment with 20 mg/kg of MTX and 5 mg/kg of CPT intraperitoneally on the fifth day. After overnight fast, rats were sacrificed, serum samples were centrifuged from blood samples and assessed for renal function parameters and electrolytes. Kidneys were assessed for oxidative stress (OS) markers and pathology. Results: Significant (P<0.001) increases in serum creatinine, urea, and uric acid levels with significant (P<0.001) decreases in total protein, albumin, potassium, sodium, chloride, and bicarbonate levels were obtained in MTX/CPT-intoxicated rats when compared to control. Furthermore, kidney malondialdehyde levels were significantly (P<0.001) increased whereas catalase, superoxide dismutase, glutathione and glutathione peroxidase levels were significantly (P<0.001) decreased in MTX/CPT-intoxicated rats when compared to control. Pathologic changes marked by atrophic glomeruli were detected in the kidneys of MTX/CPT-treated rats. However, nephrotoxicity observed in MTX/CPT-treated rats was significantly reversed in MT (P<0.01), ALA (P<0.05) and MT+ALA (P<0.001) pretreated rats when compared to MTX/CPT -treated rats. Conclusion: MT and ALA supplementations attenuate nephrotoxicity caused by MTX/CPT.

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Analytical study on the efficacy of neoadjuvant chemotherapy using a combination of methotrexate, bleomycin, and cisplatin in the management of advanced squamous cell carcinoma of the buccal mucosa

Cited by 2 publications

References 9 publications

Molecular Screening for Nigericin Treatment in Pancreatic Cancer by High-Throughput RNA Sequencing

Molecular Screening for Nigericin Treatment in Pancreatic Cancer by High-Throughput RNA Sequencing

Melatonin and alpha lipoic acid attenuate methotrexate/ cisplatin-induced kidney toxicity in albino rats

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