The effect of interface microstructure on interfacial shear strength for osteochondral scaffolds based on biomimetic design and 3D printing

Zhang, Weijie; Lian, Qin; Li, Dichen; Wang, Kunzheng; Hao, Dingjun; Bian, Weiguo; Zhang, Jin

doi:10.1016/j.msec.2014.09.042

Cited by 44 publications

(31 citation statements)

References 35 publications

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“…That way, the 3D printing technique has obtained a widespread diversity of applications for biological use, which include: the study of organ bioprinting for transplants [137]; the production of prosthetics with a lessened final cost; the production of surgical tools [138]; and the production of bioscaffolds, that work as analogues to the damaged tissue targeting tissue regeneration [139] [140]. In fact, several 3D printing techniques have already been used to design and manufacture scaffolds for medical applications, including fused deposition modeling (FDM), stereo lithography (SLA), Inkjet printing, and selective laser sintering (SLS) [141]- [143].…”

Section: D Printingmentioning

confidence: 99%

“…Even the tremendous challenge of achieving viable vascularized tissue constructs is potentially enabled by the additive processing approach [165] [166]. Another advantage of 3D printing in the biomedical field is that, unlike other techniques, it is possible to obtain a heterogeneous material with the application of different materials that can be deposited in specific positions of the final structure [140].…”

Section: D Printingmentioning

confidence: 99%

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3D Printed Scaffolds as a New Perspective for Bone Tissue Regeneration: Literature Review

Mota¹,

Silva²,

Lima³

et al. 2016

MSA

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Due to the high incidence of bone fractures in the population, it became necessary to produce scaffolds that are able to assist in tissue regeneration. It is necessary to find an appropriate balance between the mechanical and biological properties, in order to mimic the natural tissue, these properties are directly related to the architecture and their degree of porosity, as well as the size of their pores and their interconnectivity. In this perspective, the 3D printing stands out, where the structure is obtained layer by layer, according to a predetermined computational model which provides a greater control of architecture and scaffold geometry and overcomes, in this way, the limitations of traditional techniques of scaffolds manufacturing. In this way, the objective of this seminar is to present the state of the art of the polymer scaffolds produced by 3D printing and applied to bone tissue regeneration, highlighting the advantages and limitations of this process.

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Section: D Printingmentioning

confidence: 99%

Section: D Printingmentioning

confidence: 99%

3D Printed Scaffolds as a New Perspective for Bone Tissue Regeneration: Literature Review

Mota¹,

Silva²,

Lima³

et al. 2016

MSA

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“…Calcified cartilage and bone were thought to be “impermeable” [56,57,58]. However, more and more evidence indicates the presence of gomphosis and hole-like structure on native subchondral bone plate [59,60,61]. Histological imaging [55,62], scanning electron microscopy (SEM) [63,64] and dye perfusion results [65,66] confirmed the interfacial structure.…”

Section: Am-based Biomedical Constructs With Gradient Interfacesmentioning

confidence: 99%

“…The chondral PEG hydrogel was directly cured on the ceramic interface layer by layer, and a series of interface structures were designed. The interfacial shear strength of the 30% pore area group was improved almost three times over that of the 0% pore area group, and more than fifty times over that of traditional integration (5.91 ± 0.59 kPa) [61]. The integration-enhancing interface structure design implied potential applications in osteochondral tissue engineering.…”

Section: Am-based Biomedical Constructs With Gradient Interfacesmentioning

confidence: 99%

Additive Manufacturing of Biomedical Constructs with Biomimetic Structural Organizations

Zhang

et al. 2016

Materials

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Additive manufacturing (AM), sometimes called three-dimensional (3D) printing, has attracted a lot of research interest and is presenting unprecedented opportunities in biomedical fields, because this technology enables the fabrication of biomedical constructs with great freedom and in high precision. An important strategy in AM of biomedical constructs is to mimic the structural organizations of natural biological organisms. This can be done by directly depositing cells and biomaterials, depositing biomaterial structures before seeding cells, or fabricating molds before casting biomaterials and cells. This review organizes the research advances of AM-based biomimetic biomedical constructs into three major directions: 3D constructs that mimic tubular and branched networks of vasculatures; 3D constructs that contains gradient interfaces between different tissues; and 3D constructs that have different cells positioned to create multicellular systems. Other recent advances are also highlighted, regarding the applications of AM for organs-on-chips, AM-based micro/nanostructures, and functional nanomaterials. Under this theme, multiple aspects of AM including imaging/characterization, material selection, design, and printing techniques are discussed. The outlook at the end of this review points out several possible research directions for the future.

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“…[6][7][8][9][10][11] However, monitoring the strain in a curable resin during and/or after the curing process using embedded small diameter FBGs can be very useful to control the process parameters in 3D printing technology as well as to fabricate "functional" 3D objects. [11][12][13][14][15][16] The FBGs are fabricated by excimer laser exposure of bare photosensitive fibers through a phase mask, and are tested a) Electronic mail: fernando.brandi@ino.it by simultaneously recording the Bragg wavelength shift of both FBGs during UV-Vis light exposure of the resin in which the fibers are embedded. The effect of temperature on the wavelength shift is avoided by allowing the resin to thermalize at room temperature after an exposure to the UV light.…”

mentioning

confidence: 99%

Note: Strain sensitivity comparison between fiber Bragg gratings inscribed on 125 and 80 micron cladding diameter fibers, case study on the solidification monitoring of a photo-curable resin

Maccioni

Morganti

Brandi

2015

Review of Scientific Instruments

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The influence of fiber Bragg grating diameter when measuring strain is investigated and quantified. Two fiber Bragg gratings with bare cladding diameter of 125 μm and 80 μm are produced by excimer laser irradiation through a phase mask, and are used to simultaneously monitor the Bragg wavelength shift due to the strain produced by the solidification of a photo-curable resin during light exposure. It is found that the ratio of the measured strains in the two fiber Bragg gratings is close to the inverse ratio of the fiber's cladding diameter. These results represent a direct simultaneous comparison between 125 μm and 80 μm diameter fiber Bragg grating strain sensors, and demonstrate the feasibility of strain measurements in photo-curable resins using bare 80 μm cladding diameter fiber Bragg gratings with an increased sensitivity and spatial resolution compared with standard 125 μm diameter fiber Bragg gratings.

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The effect of interface microstructure on interfacial shear strength for osteochondral scaffolds based on biomimetic design and 3D printing

Cited by 44 publications

References 35 publications

3D Printed Scaffolds as a New Perspective for Bone Tissue Regeneration: Literature Review

3D Printed Scaffolds as a New Perspective for Bone Tissue Regeneration: Literature Review

Additive Manufacturing of Biomedical Constructs with Biomimetic Structural Organizations

Note: Strain sensitivity comparison between fiber Bragg gratings inscribed on 125 and 80 micron cladding diameter fibers, case study on the solidification monitoring of a photo-curable resin

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