The effect of inoculation dose of a highly pathogenic avian influenza virus strain H5N1 on the infectiousness of chickens

Spekreijse, Dieuwertje; Bouma, A.; Stegeman, J.A.; Koch, G.; Jong, M.C.M. de

doi:10.1016/j.vetmic.2010.06.012

Cited by 41 publications

(36 citation statements)

References 33 publications

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“…we made a similar observation in a previous experiment (Spekreijse et al, 2011). In that 319 experiment a small number of chickens in direct contact with experimentally infected 320 chickens tested positive in RT-qPCR and virus isolation, but did not die from infection, nor 321 seroconverted.…”

supporting

confidence: 72%

Airborne transmission of a highly pathogenic avian influenza virus strain H5N1 between groups of chickens quantified in an experimental setting

Spekreijse

Bouma

Koch

et al. 2011

Veterinary Microbiology

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Airborne transmission of a highly pathogenic avian influenza virus strain H5N1 between groups of chickens quantified in an experimental setting. Veterinary Microbiology, Elsevier, 2011, 152 (1-2) This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. study demonstrate that the rate of airborne transmission between chickens over short distances 37 is low, suggesting that airborne transmission over a long distance is an unlikely route of 38 spread. Whether or not this also applies to the field situation needs to be examined. 39 40

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supporting

confidence: 72%

Airborne transmission of a highly pathogenic avian influenza virus strain H5N1 between groups of chickens quantified in an experimental setting

Spekreijse

Bouma

Koch

et al. 2011

Veterinary Microbiology

Self Cite

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“…Such a relationship seems to hold for influenza, as suggested by a recent dose-response analysis for human influenza [51] and evidence from avian hosts [52]. Using this expression provides a measure of fitness, given by…”

Section: Ws(t)mentioning

confidence: 91%

Trade-offs between and within scales: environmental persistence and within-host fitness of avian influenza viruses

et al. 2014

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Trade-offs between different components of a pathogen's replication and transmission cycle are thought to be common. A number of studies have identified trade-offs that emerge across scales, reflecting the tension between strategies that optimize within-host proliferation and large-scale population spread. Most of these studies are theoretical in nature, with direct experimental tests of such cross-scale trade-offs still rare. Here, we report an analysis of avian influenza A viruses across scales, focusing on the phenotype of temperaturedependent viral persistence. Taking advantage of a unique dataset that reports both environmental virus decay rates and strain-specific viral kinetics from duck challenge experiments, we show that the temperature-dependent environmental decay rate of a strain does not impact within-host virus load. Hence, for this phenotype, the scales of within-host infection dynamics and between-host environmental persistence do not seem to interact: viral fitness may be optimized on each scale without cross-scale trade-offs. Instead, we confirm the existence of a temperature-dependent persistence trade-off on a single scale, with some strains favouring environmental persistence in water at low temperatures while others reduce sensitivity to increasing temperatures. We show that this temperature-dependent trade-off is a robust phenomenon and does not depend on the details of data analysis. Our findings suggest that viruses might employ different environmental persistence strategies, which facilitates the coexistence of diverse strains in ecological niches. We conclude that a better understanding of the transmission and evolutionary dynamics of influenza A viruses probably requires empirical information regarding both within-host dynamics and environmental traits, integrated within a combined ecological and within-host framework.

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“…Consequently, we chose a latent period (β) that is twice as long for the live-attenuated vaccinated chickens as for the unvaccinated chickens. Identical to the de Jong paper, this vaccination strategy showed a 7/10 survival after exposure to H5N1 contacts and the chickens showed no signs of clinical disease due to the H1N1 or H2N1 viruses and shed no viral particles associated with H1N1 or H2N1 [11].…”

Section: Determining Parametersmentioning

confidence: 61%

“…hree previous research studies had experimentally identified each of parameters we were seeking in our model using similar methods so that they could be compared [3,10,11]. These methods involved exposing over 10 chickens to different treatment conditions and housing them pair-wise in exposed cages, with each treatment group in different rooms.…”

Section: Determining Parametersmentioning

confidence: 99%

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Modeling the Effects of Avian Flu (H5N1) Vaccination Strategies on Poultry

Galvin¹,

Rumbos²,

Vincent³

et al. 2014

CODEE

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The work in this article addresses a problem posed by Dr. Maria Salvato to the CODEE community. The task was to model costs associated with varying vaccination strategies for the Avian Flu virus (H5N1) on chicken populations. The vaccination strategies proposed included vaccination varying proportions of the flock with live virus vaccine, dead virus vaccine, and no vaccination. This article encompasses the construction of a model for the problem using a modification to the SIER model and the subsequent analysis of that model. The analysis of the model revealed the most cost effective vaccination strategy to be vaccination of half the flock with dead virus vaccine.

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The effect of inoculation dose of a highly pathogenic avian influenza virus strain H5N1 on the infectiousness of chickens

Cited by 41 publications

References 33 publications

Airborne transmission of a highly pathogenic avian influenza virus strain H5N1 between groups of chickens quantified in an experimental setting

Airborne transmission of a highly pathogenic avian influenza virus strain H5N1 between groups of chickens quantified in an experimental setting

Trade-offs between and within scales: environmental persistence and within-host fitness of avian influenza viruses

Modeling the Effects of Avian Flu (H5N1) Vaccination Strategies on Poultry

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