The effect of injectable platelet-rich fibrin use in the initial treatment of chronic periodontitis

Abstract

Introduction/Objective The objective of the study was to investigate whether there are differences in therapeutic effect between initial treatments of chronic periodontitis [scaling and root planning (SRP)] alone and SRP in conjunction with injectable platelet-rich fibrin (I-PRF) application, comparing clinical parameters after three months. Methods Twenty-four patients with chronic periodontitis who had at least two sites with probing pocket depth (PPD) ≥ 5 mm on contralateral side participated in the study. Using a split-mouth design, the patients were treated with SRP + I-PRF (study group) or SRP only (control group). The clinical parameters, clinical attachment level (CAL), gingival margin level (GML), PPD, bleeding on probing, and plaque index, were recorded on both sides. Results Compared to baseline, both treatment modalities demonstrated an improvement in investigated clinical parameters. The mean value of CAL was reduced from 1.97 ± 0.75 (0.25-3.31) to 1.07 ± 0.44 (0.12-1.78) in the study group, whereas it decreased from 1.81 ± 0.66 (0.42-2.96) to 1.48 ± 0.55 (0.22-2.30) in the control group. Similarly, the corresponding values for GML and PPD showed statistically significant difference between the groups (p = 0.040 and p = 0.006, respectively). Conclusion Regardless the limited number of patients in the study, initial periodontal therapy in conjunction with injectable platelet-rich fibrin proved to display significant improvement in all clinical parameters compared to initial periodontal therapy alone.

The use of adipose-derived stem cells, platelet-rich and platelet-poor plasma in the maxillary cyst treatment

“…Although there are divided opinions regarding the use of PRP in bone regeneration, some in vivo studies from other research field have shown a positive PRP effect in stimulating the healing process of bone defects [24]. Also, advanced, second generation of platelet concentrates, platelet-rich fibrin (PRF), proved to have beneficial effect in the treatment of patients with chronic periodontitis when used in combination with conservative periodontal therapy [25].…”

Comparison between PRP vs iPRF as an adjunct therapy in Infra-bony Pocket treatment

“…Control group Ten patients received a full mouth supra -and subgingival scaling and root planing only. Figure (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12) .…”

“…Significance of the obtained results was judged at the 5% level. The power analysis was performed according to Mila et al, for adjunctive non-surgical periodontal treatment (11) . That power analysis was conducted by G power version 3.1 statistical software, Franz Faul, Universität Kiel Germany.…”

“…Injectable PRF (also known as iPRF) is a step forward from regular PRF, which retains its liquid viscosity for around 15 minutes after centrifugation, making platelet concentrate more convenient to utilize in a liquid form. (5) .…”

“…As a result, provide a more favorable environment for the regeneration and repair of these flaws (6) . PRP has previously been used as a protein covering for implant surfaces in conjunction with dental implants (5,6) . Injectable PRF is provides the benefits of advanced PRF in the form of a liquid.…”