The use of adipose-derived stem cells, platelet-rich and platelet-poor plasma in the maxillary cyst treatment

Abstract

Introduction. The case report describes the effect of combination therapy using adipose-derived stem cells (ADSC), platelet-rich plasma (PRP) and platelet-poor plasma (PPP) in the treatment of a maxillary cyst. Case outline. A maxillary cyst between the central incisors was identified in a healthy 54-year-old male patient during a routine dental check-up. Following thorough clinical and radiographic examinations, the treatment plan was presented and explained to the patient and written informed consent was obtained. Initially, the conservative periodontal treatment was performed. Afterwards, the adipose tissue was collected from the patient's belly fat and ADSC, PRP and PPP were obtained, following the Institution's surgical and laboratory protocols. The maxillary cyst was then surgically removed and ADSC, PRP, PPP and resorptive collagenous membrane were placed on the surgical site. Three-year-follow up radiographs showed significantly reduced radiolucency and bone regeneration around apexes of central incisors. Clinically, there were no signs of inflammation or pain. Conclusion. The positive outcome of the case presented in this report could be considered as a promising way to treat large bone defects using ADSC, PRP and PPP.