The effect of inhibitors of protein and nucleic acid synthesis on nucleolar size and enzyme induction in Jerusalem artichoke tuber slices

Abstract

The effects of various inhibitors of protein and nucleic acid synthesis on the development of invertase activity and increased nucleolar volume in discs excised from tubers of artichoke tissue are compared. The results are discussed with reference to the current theories relevant to the action of the inhibitors and to the nature of the increase in nucleolar volume.

Suppression effect of CIPC on nucleoli in Vicia faba root tip cells.

“…Vacuolation of nucleoli may be related to transport of RNA products (Johnson and Jones 1967, Johnson 1969, Rose et al 1972, De Barsy et al 1974). This increase in nu cleolar size was completely inhibited by actinomycin D and by cycloheximide, so measurement of changes in nucleolar size was considered to be a sensitive indicator of cell activity (King andChapman 1972, Rose 1974).…”