The effect of individual dietary constituents on antipyrine clearance in Asian immigrants [proceedings]

Mucklow, JC; Caraher, MT; Henderson, DB; Rawlins,

doi:10.1111/j.1365-2125.1979.tb00961.x

Cited by 12 publications

(5 citation statements)

References 2 publications

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“…The data on the role of dietary protein in healthy participants and severely ill patients are supported by observations in vegetarians: differences of drug metabolism found in individuals adhering to vegetarian or traditional diets [87][88][89] are likely to be related to protein intake: the differences of drug clearance are minor when the protein supply in vegetarians is equivalent to a ' normal' intake in nonvegetarians on a balanced Western diet. The systemic clearance of cyclosporin was reported to be increased in kidney transplant recipients on a high-fat diet (160 g/day) compared with the values on a low-fat diet (29 g/day).…”

Section: Effect Of Prolonged Dietary Changes and Of Parenteral Nutritionmentioning

confidence: 82%

Influence of Diet and Nutritional Status on Drug Metabolism

Walter‐Sack

Klotz

1996

Clinical Pharmacokinetics

179

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Genetic and environmental factors contribute to a wide inter- and intraindividual variability in drug metabolism. Among the environmental factors that may influence drug metabolism, the diet and nutritional status of the individuals are important determinants. As altered drug-metabolising enzyme activities can influence the intensity and duration of drug action, such factors should be considered in pharmacotherapy. For this reason the effects of dietary energy, protein deficiency, nutritional ingredients, special diet forms and nutrition regimens and malnutritional states must be differentiated. In various pharmacokinetic studies different model drugs metabolised either by oxidative phase I pathways [e.g. phenazone (antipyrine), aminopyrine, phenacetin, theophylline, propranolol, nifedipine] or phase II conjugation reactions [e.g. paracetamol (acetaminophen), oxazepam] were used and from the calculated pharmacokinetic data some information on the involved and affected drug-metabolising enzymes [e.g. cytochrome P450 (CYP) subspecies, glucuronosyltransferases] can be generated. It is well known that smoking, charcoal broiled food or cruciferous vegetables induce the metabolism of many xenobiotics, whereas grapefruit juice increases the oral bioavailability of the high clearance drugs nifedipine, nitrendipine or felodipine by inhibiting their presystemic (intestinal) elimination. Energy deficiency, and especially a low intake of protein, will cause a decrease of about 20 to 40% in phenazone and theophylline clearance and elimination of those drugs can be accelerated by a protein-rich diet. In the same way, protein deficiency induced by either vegetarian food or undernourishment will have the opposite pharmacokinetic consequences. On the basis of some more examples from the literature it is emphasised that the variable influence of the above factors should be taken into account in study participant selection and study design when the pharmacokinetics of a drug must be determined in healthy individuals and/or patients.

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Section: Effect Of Prolonged Dietary Changes and Of Parenteral Nutritionmentioning

confidence: 82%

Influence of Diet and Nutritional Status on Drug Metabolism

Walter‐Sack

Klotz

1996

Clinical Pharmacokinetics

179

View full text Add to dashboard Cite

show abstract

“…A comparison of antipyrine clearance between vegetarian and non-vegetarian Indo-Pakistani immigrants to Britain (Mucklow, Caraher, Henderson & Rawlins, 1979) showed that clearance amongst meat-eating immigrants was significantly greater than in vegetarians. However, multiple regression ane0ysis suggested that this might be associated with the consumption of animal fat, rather than protein.…”

mentioning

confidence: 99%

The influence of changes in dietary fat on the clearance of antipyrine and 4‐hydroxylation of debrisoquine.

Mucklow¹,

Caraher²,

Rawlins³

et al. 1980

Brit J Clinical Pharma

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“…This study has shown that vegetarian Asians with low circulating 25-OHD levels also metabolize antipyrine slowly. This may be consequent upon their vegetarian diet as Asians who eat meat have a higher antipyrine clearance than racially identical lactovege- (Mucklow, Caraher, Henderson & Rawlins, 1979). These data might also indicate involvement of the same cytochrome P 450-dependent oxidizing enzyme in the liver endoplasmic reticulum in the metabolism of vitamin D and antipyrine.…”

Section: Discussionmentioning

confidence: 99%

Reduction of circulating 25‐hydroxyvitamin D by antipyrine.

Wilmana¹,

Brodie²,

Mucklow³

et al. 1979

Brit J Clinical Pharma

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1 Twenty‐four Asian vegetarians had significantly lower 25‐ hydroxyvitamin D (25‐OHD) levels and longer antipyrine half‐lives than twenty white non‐vegetarians (P less than 0.001). 2 Treatment with oral antipyrine over 4 or 5 weeks in seven vegetarian Asians and five racially different non‐vegetarians increased drug oxidation significantly in both groups as measured by a fall in antipyrine half‐ lives and a rise in serum gamma‐glutamyltranspeptidase levels and urinary 6 beta‐hydroxycortisol/17‐hydroxycorticosteroid ratios. 3 Antipyrine treatment produced a fall in circulating 25‐hydroxyvitamin D of around 60% in all subjects in whom pretreatment levels could be measured, independent of race and diet. 4. In the Caucasian non‐ vegetarian group 1,25 dihidroxyvitamin D levels, the most active metabolite of vitamin D, were also measured and remained unaltered despite a substantial fall in 25‐hydroxy substrate. 5 The acute fall in 25‐hydroxyvitamin D concentration with a maintained level of 1,25 dihidroxyvitamin D may represent the early changes of drug‐induced osteomalacia.

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The effect of individual dietary constituents on antipyrine clearance in Asian immigrants [proceedings]

Cited by 12 publications

References 2 publications

Influence of Diet and Nutritional Status on Drug Metabolism

Influence of Diet and Nutritional Status on Drug Metabolism

The influence of changes in dietary fat on the clearance of antipyrine and 4‐hydroxylation of debrisoquine.

Reduction of circulating 25‐hydroxyvitamin D by antipyrine.

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