The influence of changes in dietary fat on the clearance of antipyrine and 4‐hydroxylation of debrisoquine.

The relationship between individual dietary constituents and antipyrine metabolism in Indo‐Pakistani immigrants to Britain.

“…It also lends support to the argument that the difference in antipyrine clearance found in the earlier study in London (Fraser et al, 1979) whereas manipulation of dietary fat has no such effect Mucklow et al, 1980). It …”

“…A study among Hindus living in East Punjab (Chaudhury, personal communication) has likewise shown that a vegetarian diet does not result in reduction of antipyrine clearance: the vegetarian diet of the Punjab is characterised by its rich protein content, and differs markedly in that respect from the diet enjoyed by the Gujarati. Furthermore deliberate manipulation of dietary protein in man has been shown to modify the clearance of both antipyrine and theophylline whereas manipulation of dietary fat has no such effect Mucklow et al, 1980). It therefore seems likely that the difference in antipyrine clearance between vegetarian and non-vegetarian immigrants studied here resulted from the contrasting amounts of protein in the two diets.…”

Ethnocultural influences in evaluation and management.

“…Traditional Chinese and Japanese diets contain less than half the fat of Western diets, and researchers have suggested that the increase in colorectal and breast cancer among Chinese and Japanese Americans may be attributable, in part, to their change from traditional, low-fat diets to American high-fat diets. Other studies have shown that when immigrants change from their original culture's dietary habits to eat a Western diet their responses to certain drugs become more similar to those of Western Whites (Mucklow et al, 1980(Mucklow et al, , 1982. In one study, which compared the metabolism of antipyrine in Whites and East Indians living in Britain with that of East Indians living in India, researchers found that the pharmacokinetics of antipyrine in East Indian Britons who maintained a traditional Indian vegetarian diet were similar to East Indians living in India, whereas the pharmacokinetic profile of East Indians who ate meat was more similar to that of the British Whites (Desai et al, 1980;Dollery, Fraser, Mucklow, & Bulpitt, 1979).…”