The effect of <i>Achillea millefolium</i> and <i>Hypericum perforatum</i> ointments on episiotomy wound healing in primiparous women

Hajhashemi, Maryam; Ghanbari, Zinat; Movahedi, Minoo; Mahmoud, Rafieian; Keivani, Atefeh; Haghollahi, Fedyeh

doi:10.1080/14767058.2016.1275549

Cited by 47 publications

(30 citation statements)

References 16 publications

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“…Hajhashemi et al () assessed the efficacy of A. millefolium ointments on episiotomy wound healing in 140 primiparous women by doing double‐blind clinical trial. Healing process was assessed by five specifications: redness, ecchymosis, edema, discharge and wound dehiscence at 7th, 10th and 14th day after delivery, and pain level was assessed by means of visual analogue scale.…”

Section: Clinical Datamentioning

confidence: 99%

Pharmacognosy, Phytochemistry and Pharmacological Properties ofAchillea millefoliumL.: A Review

2017

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Achillea millefoilum L. (Yarrow) is an important species of Asteraceae family with common utilization in traditional medicine of several cultures from Europe to Asia for the treatment of spasmodic gastrointestinal disorders, hepatobiliary, gynecological disorders, against inflammation and for wound healing. An extensive review of literature was made on A. millefoilum L. using ethno botanical text books, published articles in peer-reviewed journals, unpublished materials and scientific databases. The Plant List, International Plant Name Index and Kew Botanical Garden databases were used to authenticate the scientific names. Monoterpenes are the most representative metabolites constituting 90% of the essential oils in relation to the sesquiterpenes, and a wide range of chemical compounds have also been reported. Different pharmacological experiments in many in-vitro and in-vivo models have proved the potential of A. millefoilum with antiinflammatory, antiulcer, anticancer activities etc. lending support to the rationale behind numerous of its traditional uses. Due to the noteworthy pharmacological activities, A. millefoilum will be a better option for new drug discovery. The present review will comprehensively summarize the pharmacognosy, phytochemistry and ethnopharmacology of A. millefoilum reported to date, with emphasis on more in vitro, clinical and pathological studies needed to investigate the unexploited potential of this plant. Copyright © 2017 John Wiley & Sons, Ltd.

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Section: Clinical Datamentioning

confidence: 99%

Pharmacognosy, Phytochemistry and Pharmacological Properties ofAchillea millefoliumL.: A Review

2017

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“…Yarrow extract has shown spasmogenic effects on murine and human gastric antrum, consistent with its traditional use to treat dyspepsia [513]. In a double-blind clinical trial, A. millefolium ointment was shown to reduce pain, inflammation, and ecchymosis in episiotomy wound healing [514].…”

Section: Cherokee Aromatic Medicinal Plants Currently In Use As Herbamentioning

confidence: 66%

The Phytochemistry of Cherokee Aromatic Medicinal Plants

Setzer

2018

Medicines

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Background: Native Americans have had a rich ethnobotanical heritage for treating diseases, ailments, and injuries. Cherokee traditional medicine has provided numerous aromatic and medicinal plants that not only were used by the Cherokee people, but were also adopted for use by European settlers in North America. Methods: The aim of this review was to examine the Cherokee ethnobotanical literature and the published phytochemical investigations on Cherokee medicinal plants and to correlate phytochemical constituents with traditional uses and biological activities. Results: Several Cherokee medicinal plants are still in use today as herbal medicines, including, for example, yarrow (Achillea millefolium), black cohosh (Cimicifuga racemosa), American ginseng (Panax quinquefolius), and blue skullcap (Scutellaria lateriflora). This review presents a summary of the traditional uses, phytochemical constituents, and biological activities of Cherokee aromatic and medicinal plants. Conclusions: The list is not complete, however, as there is still much work needed in phytochemical investigation and pharmacological evaluation of many traditional herbal medicines.

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“…Several studies were carried out on this standard mixture of wound healing. Achillea millefolium has been shown to accelerate wound healing with its effect on collagen production, wound proliferation phase (20) and edema (21). Juglans regia has antioxidant, antimicrobial and wound healing activity (22,23), Lycopodium clavatum has been shown to have potential effects on inhibition of ROS production and tissue repair associated signaling pathways during wound healing (24,25).…”

Section: Discussionmentioning

confidence: 99%

The Effect of algan hemostatic agent (AHA) on wound healing

Aksoy

Şener

Akakın

et al. 2020

Clinical and Experimental Health Sciences

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Objective: The Algan Hemostatic Agent (AHA) is a novel herbal originated blood stopper. The aim of this study is to investigate the effect of AHA on wound healing on excisional wound model in rats. Methods: In this study, 54 adult Wistar albino rats were used. Rats were divided into 3 groups (saline, Madecassol® and AHA). Each group was then divided into 3 subgroups as the 3 rd , 7 th and 14 th days. Two wounds were created in the dorsal thoracic region of the rats. One of the lesions was used for histopathological examinations and the other for hydroxyproline measurement. In order to evaluate the wound healing, wound area were measured during the whole treatment period and animals were sacrificed at the end of the 3 rd , 7 th and 14 th days and tissue samples were taken for the determination of hydroxyproline levels. Results: AHA treatment did not cause significant difference in hydroxyproline level on days 3, 7, 14. The contraction percentage of wound area was higher in the AHA group on day 7 than that of the control group. However, the difference was not statistically significant (p>0.05). On days 3 and 14, no significant difference was detected in the contraction percentage of wound area between the control and the AHA groups. AHA and Madecassol® results of epidermis regeneration on the 14 th day, neutrophil infiltration on the 7 th day and edema on the 3 rd , 7 th and 14 th days were different in terms of histopathological parameters compared to the control group. Conclusion: Despite good histological findings, AHA did not significantly accelerate wound healing, but did not adversely affect wound healing as well.

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The effect of Achillea millefolium and Hypericum perforatum ointments on episiotomy wound healing in primiparous women

Abstract: Achillea millefolium and Hypericum perforatum ointments reduce perineal pain level, redness, edema and ecchymosis of episiotomy wound, so it seems that consuming them was useful for episiotomy treatment.

Cited by 47 publications

References 16 publications

Pharmacognosy, Phytochemistry and Pharmacological Properties ofAchillea millefoliumL.: A Review

Pharmacognosy, Phytochemistry and Pharmacological Properties ofAchillea millefoliumL.: A Review

The Phytochemistry of Cherokee Aromatic Medicinal Plants

The Effect of algan hemostatic agent (AHA) on wound healing

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