The Effect of Hyperglycemia on Pulpal Healing in Rats

Influence of diabetes mellitus on the mineralization ability of two endodontic materials

“…22 Hyperglycemia increases the levels of systemic inflammatory markers 2 impairing the wound healing process; it also contributes to systemic and oral manifestations, which have a direct effect on dental pulp integrity. 4,5 In the present study, the inflammatory reaction observed for the control group was similar to previously reported findings of absence of Von Kossa-positive areas and structures birefringent to polarized light and basal fluorescence intensity. 12,20 MTA Fillapex ® induced a mild inflammatory response, which is in agreement with previously reported findings.…”

“…23 Our findings are in disagreement with those of previous studies that showed that DM altered various functions of the immune system and is associated with delayed healing, predisposition to chronic inflammation, diminished tissue repair capacity, and alteration of the inflammatory response. 4,5 There are conflicting data to suggest that the relationship of DM and biocompatibility is not yet completely understood, and other studies using different methods are warranted.…”

“…4,5 The compromised immune responses contribute to increased susceptibility to infections 2,3 and leads to predisposition to a wide spectrum of oral diseases including pulpal and periapical infections. 4,5 Fouad 6 showed that DM may be a modulating factor of endodontic infections and may compromise the healing process of periapical tissues.…”

Mineral Trioxide Aggregate: A Comprehensive Literature Review—Part III: Clinical Applications, Drawbacks, and Mechanism of Action

“…In an animal study, mechanical dental pulp exposure in intentionally induced hyperglycemic rats showed more inflammation and demonstrated a lower rate of dentin bridge formation compared with normal rats, despite using MTA as the capping material (19). Most animal studies comparing MTA with other pulp capping agents showed more favorable results with MTA (7,8,10,12,13).…”

High Glucose Levels Increase Osteopontin Production and Pathologic Calcification in Rat Dental Pulp Tissues

“…In oral tissues, periodontal disease is well-known to be prevalent in diabetic patients. Endodontic research demonstrated that dentin bridge formation was inhibited in diabetic rats (18), diabetes modified the parameters of the antioxidant system of rat dental pulp tissues (19), and more calcifications in dental pulp tissues were found in diabetic than in nondiabetic subjects (20). Diabetic patients often experience vascular complications, including atherosclerosis, nephropathy, and retinopathy.…”