Mineral Trioxide Aggregate: A Comprehensive Literature Review—Part III: Clinical Applications, Drawbacks, and Mechanism of Action

Parirokh, Masoud; Torabinejad, Mahmoud

doi:10.1016/j.joen.2009.09.009

Cited by 1,052 publications

(1,005 citation statements)

References 238 publications

(310 reference statements)

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“…In addition, MTA has shown antibacterial and excellent sealing properties (1,2). However, despite its favorable characteristics, MTA does not exhibit the physical properties required for an endodontic sealer, because of its working time, setting time and difficult handling (3).…”

Section: Introductionmentioning

confidence: 99%

Long-Term Cytotoxicity, pH and Dissolution Rate of AH Plus and MTA Fillapex

et al. 2016

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The aim of the present study was to verify the long-term cytotoxic effects of the MTA Fillapex and to compare them with AH Plus. Dissolution rate and pH were also evaluated. Human osteoblast cells were incubated with elutes of fresh specimens from AH Plus and MTA Fillapex, and with elutes of the same specimens for 4 successive weeks. Elute's pH was evaluated at each time point. A multiparametric cell viability assay was performed. For dissolution rate, ISO methodology was used. The results were analyzed by one-way analysis of variance, complemented with the Tukey post-test (p<0.05). No significant difference was found among the materials when fresh mixed (p>0.05). After 1 week, AH Plus became non-cytotoxic on all three evaluated parameters. Conversely, MTA Fillapex remained severely and mildly cytotoxic over the entire experimental period (p<0.05). The dissolution rate of AH Plus was significantly lower than MTA Fillapex at all time points (p>0.05). The pH of AH Plus was significantly lower than MTA Fillapex at the second and third week (p<0.05). In the other tested time points no statistical difference was observed.In conclusion, MTA Fillapex remained cytotoxic after 4 weeks and its cytotoxicity may be related to the high dissolution rate of this material.

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Section: Introductionmentioning

confidence: 99%

Long-Term Cytotoxicity, pH and Dissolution Rate of AH Plus and MTA Fillapex

et al. 2016

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“…Its clinical use could be widened because of these characteristics, as in pulpotomy, direct pulp capping, apexifications, sealing perforation, retro-restorations and endodontic complications such as root and furcation perforation 3 . Regarding the MTA, manufacturers recommend the use of distilled water as vehicle.…”

Section: Introductionmentioning

confidence: 99%

Aloe vera as vehicle to mineral trioxide aggregate: study in bone repair

Fé

Coelho

Damascena

et al. 2014

Rev. odontol. UNESP

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AIM: Mineral trioxide aggregate (MTA) was associated to Aloe vera to verify the coadjutant action of that medicinal plant in the bone neoformation process in tibia of rats.MATERIAL AND METHOD: 36 male rats (Rattus norvegicus) were used, divided into two groups of 18 rats each. Two circumferential bone defects with approximately 5 mm in diameter were made on the right tibia of each animal: the upper defect was filled with blood coagulates in both groups to serve as experimental control and the lower defect was filled with MTA and Aloe vera in experimental (group E1) and MTA and distilled water in experimental (group E2). Seven, 15 and 30 days after surgery, six animals from each group were euthanized and the right tibia of each animal was removed for histological analysis.RESULT: Histologically, experimental group E1 presented better results for the two variables, inflammation [at seven days (p=0.045)] and bone formation [at seven days (p=0.018) and 30 days (p=0.034)], compared to the E2 group.CONCLUSION: The association of MTA and Aloe vera showed potential to reduce the effects of the inflammatory cascade and promote bone neoformation making it to a promising proposal for future use in endodontic therapy.

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“…MTA is a bioactive material that is mainly composed of tricalcium and silicate. Scientific investigations have shown that MTA can release various ions thatconduct and induct hard-tissue formation 4,17 .MTA presents some advantages,including its physical characteristics thatguarantee expansion during the attachment, which favors sealing, and the biological properties ofcalcium hydroxide 3,24 . MTA forms calcium oxide when in contact with water, which then, when in contact with tissue fluids, forms calcium hydroxide and triggers the same repair process in the tissue 11 .Some recentstudies have reported on the success of MTA as a root apical barrier, with rates ranging from 76.5% to 91% 10,20 .…”

Section: Discussionmentioning

confidence: 99%

“…One of the major challenges in endodontic treatment of teeth with open apices due to resorption is achieving effective debridement, canal disinfection and subsequent sealing of the root canal space. The key point is to form an apical barrier or a stop against which one can place the sealer and gutta-percha, while avoiding over-extrusion 17,21 .Mineral trioxide aggregate (MTA) is a reliable material due to its biocompatibility and good sealing properties,which providesopportunities for the regeneration of periapical tissues,such as periodontal ligament, bone and cementum 1,2,15 .…”

Section: Introductionmentioning

confidence: 99%

Orthograde Apical Application of an MTA Plug in a Tooth without Constriction - A Case Report

2016

IJSR

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Abstract:The periapical area in teeth with chronic lesions is characterized by changes in the adjacent bone structure and periodontal ligaments, as well as in the cement and dentine. In a large percentage of cases, the apical physiological constriction is ether absent or expanded. The absence of a constriction makes it a challenge to achieve satisfactory treatment results.The present case report describes the re-treatment of a case of a mandibular molar, complicated by lack of constriction and a separated endodontic instrument. Mineral trioxide aggregate (MTA) was used for a 5-mm apical plug to avoid overfilling of the sealer when the root canal was definitely obturated. The periapical radiographs showed satisfactory images of periapical bone density and the tooth was asymptomatic on precision. MTA is proved to be an appropriate material for apical sealing in cases with resorption, as it leads to avoidance of apical surgical procedures with a similar prognostic outcome.

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Mineral Trioxide Aggregate: A Comprehensive Literature Review—Part III: Clinical Applications, Drawbacks, and Mechanism of Action

Cited by 1,052 publications

References 238 publications

Long-Term Cytotoxicity, pH and Dissolution Rate of AH Plus and MTA Fillapex

Long-Term Cytotoxicity, pH and Dissolution Rate of AH Plus and MTA Fillapex

Aloe vera as vehicle to mineral trioxide aggregate: study in bone repair

Orthograde Apical Application of an MTA Plug in a Tooth without Constriction - A Case Report

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