The effect of hypercholesterolaemia and atherosclerosis on α-adrenoceptor-mediated vasoconstriction in conscious rabbits and rabbit aorta

Endothelial dysfunction and improvement of the angiotensin II-reactivity in hypercholesterolemic rabbits: Role of cyclooxygenase metabolites

“…In addition, van der Linde et al (2006) reported that low density lipoproteincholesterol levels directly influence angiotensin II sensitivity in healthy, young subjects with isolated hypercholesterolemia. By contrast, the contractile response to noradrenaline was decreased in arteries from hypercholesterolemic rabbits, which is in agreement with data from the literature (Verbeuren et al, 1986;Du and Woodman, 1992).…”

Differential impact of severe familial hypercholesterolemia on regional skeletal muscle and organ blood flows during exercise: Effects of PDE5 inhibition

“…Specifically, relative to BVO 2 , FH swine exhibit increased HR at rest and during exercise and an exaggerated MAP response to exercise compared to normal swine . Further, altered local vasomotor responses of the splanchnic microcirculation to sympathetic activation in FH may also contribute to reduced blood flows as enhanced mesenteric artery vasoconstriction to the α 1 ‐adrenoceptor agonist phenylephrine has been reported in hypercholesterolemic rabbits . Whether the reduction in basal splanchnic blood flows leading to a limitation of further splanchnic vasoconstriction during exercise in FH contributes to the inability of FH swine to exercise beyond the intensity used in this study, however, is unclear.…”