Differential impact of severe familial hypercholesterolemia on regional skeletal muscle and organ blood flows during exercise: Effects of PDE5 inhibition
Abstract:Objective
Swine with familial hypercholesterolemia (FH) exhibit attenuated exercise‐induced systemic vasodilation that is restored by phosphodiesterase 5 (PDE5) inhibition. Whether the impacts of FH and PDE5 inhibition to impair and restore exercise‐induced vasodilation, respectively, results from tissue‐specific or generalized effects remains unclear. Thus, we hypothesized that FH induces generalized impairment of skeletal muscle vasodilation that would be alleviated by PDE5 inhibition.
Methods
Systemic vascu… Show more
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