The Effect of Hyperbaric Oxygen on Cerebral Hemoglobin Oxygenation and Dissociation Rate of Carboxyhemoglobin in Anesthetized Rats: Spectroscopic Approach

Araki, Ryuichiro; Nashimoto, I; Takano, Takehito

doi:10.1007/978-1-4615-9510-6_44

Cited by 14 publications

(6 citation statements)

References 7 publications

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“…Thus, the confounding influence of tobacco smoke exposure on inflammatory indices needs to be addressed. However, it should be noted that a further advantage of optical spectroscopy is that because carbon monoxygenated hemoglobin has a distinct visible spectrum (38), the analysis of periodontal spectra may also be able to define the smoking status of individuals concurrently with disease indices. Indeed, we have recently observed multiple alterations to the molecular and biochemical profile of serum from smokers and nonsmokers (39).…”

Section: Discussionmentioning

confidence: 99%

In vivo determination of multiple indices of periodontal inflammation by optical spectroscopy

Liu

Xiang

Man

et al. 2009

J of Periodontal Research

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Background and Objective Visible – near infrared (optical) spectroscopy can be used to measure regional tissue hemodynamics and edema and, therefore, may represent an ideal tool with which to non-invasively study periodontal inflammation. The study objective was to evaluate the ability of optical spectroscopy to simultaneously determine multiple inflammatory indices (tissue oxygenation, total tissue hemoglobin, deoxyhemoglobin, oxygenated hemoglobin, and tissue edema) in periodontal tissues in vivo. Material and Methods Spectra were obtained, processed, and evaluated from healthy, gingivitis, and periodontitis sites (n = 133) using a portable optical – near infrared spectrometer. A modified Beer-Lambert unmixing model that incorporates a nonparametric scattering loss function was used to determine the relative contribution of each inflammatory component to the overall spectrum. Results Optical spectroscopy was harnessed to successfully generate complex inflammatory profiles in periodontal tissues. Tissue oxygenation at periodontitis sites was significantly decreased (p<0.05) compared to gingivitis and healthy controls. This is largely due to an increase in deoxyhemoglobin in the periodontitis sites compared to healthy (p<0.01) and gingivitis (p=0.05) sites. Tissue water content per se showed no significant difference between the sites but a water index associated with tissue electrolyte levels and temperature differed was significantly between periodontitis sites when compared to both healthy and gingivitis sites (p<0.03). Conclusion This study establishes that optical spectroscopy can simultaneously determine multiple inflammatory indices directly in the periodontal tissues in vivo. Visible - near infrared spectroscopy has the potential to be developed into a simple, reagent-free, user friendly, chair-side, site-specific, diagnostic and prognostic test for periodontitis.

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Section: Discussionmentioning

confidence: 99%

In vivo determination of multiple indices of periodontal inflammation by optical spectroscopy

Liu

Xiang

Man

et al. 2009

J of Periodontal Research

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“…Increasing the partial pressure of oxygen decreases the half-life of CO-Hgb. The reported half-life of CO-Hgb is 240 to 320 minutes at room air (21% oxygen), 40 to 80 minutes at 100% oxygen, and approximately 20 minutes at 100% HBOT at 2.5 to 3.0 ATA [12,[177][178][179]. Wide individual variation exists, however, and prolonged exposures may result in prolonged half-life [177,180].…”

Section: Treatmentmentioning

confidence: 98%

Carbon monoxide poisoning

Kao¹,

Nañagas²

2004

Emergency Medicine Clinics of North America

167

171

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“…In CO-intoxicated patients, HBOT attenuates long-term neurological sequelae (45,48). Interestingly, in contrast with HBOT, normobaric oxygen breathing (inspired O 2 fraction ϭ 1.0) did not reduce mortality or neurological morbidity in similar experiments using microdialysis (5,26,27,47). In addition, normobaric oxygen therapy had no effect on the reduced state of cytochrome oxidase a 3 during CN exposures (12,36,49).…”

Section: Mechanisms Of Actionmentioning

confidence: 91%

Combined administration of hyperbaric oxygen and hydroxocobalamin improves cerebral metabolism after acute cyanide poisoning in rats

Hansen

Olsen

Hyldegaard

2013

Journal of Applied Physiology

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Hyperbaric oxygen therapy (HBOT) or intravenous hydroxocobalamin (OHCob) both abolish cyanide (CN)-induced surges in interstitial brain lactate and glucose concentrations. HBOT has been shown to induce a delayed increase in whole blood CN concentrations, whereas OHCob may act as an intravascular CN scavenger. Additionally, HBOT may prevent respiratory distress and restore blood pressure during CN intoxication, an effect not seen with OHCob administration. In this report, we evaluated the combined effects of HBOT and OHCob on interstitial lactate, glucose, and glycerol concentrations as well as lactate-to-pyruvate ratio in rat brain by means of microdialysis during acute CN poisoning. Anesthetized rats were allocated to three groups: 1) vehicle (1.2 ml isotonic NaCl intra-arterially); 2) potassium CN (5.4 mg/kg intra-arterially); 3) potassium CN, OHCob (100 mg/kg intra-arterially) and subsequent HBOT (284 kPa in 90 min). OHCob and HBOT significantly attenuated the acute surges in interstitial cerebral lactate, glucose, and glycerol concentrations compared with the intoxicated rats given no treatment. Furthermore, the combined treatment resulted in consistent low lactate, glucose, and glycerol concentrations, as well as in low lactate-to-pyruvate ratios compared with CN intoxicated controls. In rats receiving OHCob and HBOT, respiration improved and cyanosis disappeared, with subsequent stabilization of mean arterial blood pressure. The present findings indicate that a combined administration of OHCob and HBOT has a beneficial and persistent effect on the cerebral metabolism during CN intoxication.

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The Effect of Hyperbaric Oxygen on Cerebral Hemoglobin Oxygenation and Dissociation Rate of Carboxyhemoglobin in Anesthetized Rats: Spectroscopic Approach

Cited by 14 publications

References 7 publications

In vivo determination of multiple indices of periodontal inflammation by optical spectroscopy

In vivo determination of multiple indices of periodontal inflammation by optical spectroscopy

Carbon monoxide poisoning

Combined administration of hyperbaric oxygen and hydroxocobalamin improves cerebral metabolism after acute cyanide poisoning in rats

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