The Effect of Hyperbaric Oxygen Therapy on a Burn Wound Model in Human Volunteers

Niezgoda, JA; Cianci, PE; Folden, B W; Ortega, R. L.; Slade, JB; Storrow, Alan B.

doi:10.1097/00006534-199705010-00023

Cited by 31 publications

(20 citation statements)

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“…Therapeutic HBO can increase the mobilization of endothelial progenitor cells from the bone marrow into peripheral blood, which has the clear potential of benefiting wound healing in patients affected by diabetes and peripheral arterial disease 9 . A randomized blind study examining the effects of HBO therapy on experimental wounds in humans noted that the HBO group significantly benefited from a 42% reduction in wound hyperaemia, a 35% reduction in the size of the lesion and a 22% reduction in wound exudation 38 . The favourable effects of HBO in clinical studies are supported by numerous experimental studies demonstrating that HBO therapy improves tissue oxygenation 39–44 .…”

Section: Discussionmentioning

confidence: 99%

Topical Oxygen Therapy Induces Vascular Endothelial Growth Factor Expression and Improves Closure of Clinically Presented Chronic Wounds

Gordillo¹,

Roy²,

Khanna³

et al. 2008

Clin Exp Pharma Physio

101

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1.Chronic wounds, especially in diabetics, represent a serious threat to human health. 2.Correcting a compromised state of tissue oxygenation by the administration of supplemental O 2 is known to benefit wound healing. Beyond its role as a nutrient and antibiotic, O 2 supports wound healing by driving redox-signaling.3. HBO (hyperbaric oxygen) therapy is widely used and approved by CMS to treat specific ulcerations. The current literature supports that approaches to topically oxygenate wounds may be productive. 4.Here, we present the results of two simultaneous studies testing the effects of HBO and portable topical oxygen (TO) therapies. These two therapeutic approaches have several contrasting features. 5.A total of 1854 patients were screened in outpatient wound clinics for non-randomized enrollments into the HBO (n=32, 31% diabetic) and TO (n=25, 52% diabetic) studies.

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Section: Discussionmentioning

confidence: 99%

Topical Oxygen Therapy Induces Vascular Endothelial Growth Factor Expression and Improves Closure of Clinically Presented Chronic Wounds

Gordillo¹,

Roy²,

Khanna³

et al. 2008

Clin Exp Pharma Physio

101

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“…Epidermization lesions were not observed. Thus, the authors consider hyperbaric oxygen therapy to be beneficial in the management of superficial skin wounds (64). The Swedish authors came to the same conclusions (65).…”

Section: Clinical Studiesmentioning

confidence: 79%

Hyperbaric Oxygen Therapy of Burns

Strużyna¹,

Staroń²,

Krajewski³

2008

Polish Journal of Surgery

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“…This will increase the power for a prognostication model that will incorporate a wide range of both clinical and lab biomarkers. This will allow us to comprehensively risk stratify patients to identify those who would most benefit from early and aggressive wound care therapies such as hyperbaric oxygen, wound vacuum, or skin grafting [24][25][26].…”

Section: Resultsmentioning

confidence: 99%

Stratification of Highest-Risk Patients with Chronic Skin Ulcers in a Stanford Retrospective Cohort Includes Diabetes, Need for Systemic Antibiotics, and Albumin Levels

Amir

Liu

Chang

2012

Ulcers

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Chronic nonsurgical skin wounds such as venous stasis and diabetic ulcers have been associated with a number of comorbid conditions; however, the strength of these associations has not been compared. We utilized the Stanford Translational Research Integrated Database Environment (STRIDE) system to identify a cohort of 637 patients with chronic skin ulcers. Preliminary analysis (n = 300) showed that 49.7% of the patients had a poor prognosis such as amputation or a nonhealing ulcer for at least a year. Factors significantly associated (P < 0.05) with these outcomes included diabetes mellitus, chronic kidney disease, peripheral neuropathy, peripheral arterial disease, and need for systemic antibiotics. Patients with poor outcomes also tended to have lower hemoglobin levels (P = 0.01), higher WBC levels (P < 0.01), and lower albumin levels (P < 0.01). On multivariate analysis, however, only diabetes mellitus (OR 5.87,3), need for systemic antibiotics (OR 3.88,, and albumin levels (0.20 per unit, 0.07-0.60) remained significant independent predictors of poor wound-healing outcomes. These data identify patients at the highest risk for poor wound-healing and who may benefit the most from more aggressive wound care and treatment.

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The Effect of Hyperbaric Oxygen Therapy on a Burn Wound Model in Human Volunteers

Cited by 31 publications

References 0 publications

Topical Oxygen Therapy Induces Vascular Endothelial Growth Factor Expression and Improves Closure of Clinically Presented Chronic Wounds

Topical Oxygen Therapy Induces Vascular Endothelial Growth Factor Expression and Improves Closure of Clinically Presented Chronic Wounds

Hyperbaric Oxygen Therapy of Burns

Stratification of Highest-Risk Patients with Chronic Skin Ulcers in a Stanford Retrospective Cohort Includes Diabetes, Need for Systemic Antibiotics, and Albumin Levels

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