Hyperbaric Oxygen Therapy of Burns

Therapeutic Outcome of Burn Patients Treated With Hyperbaric Oxygen

“…Hence, there is insufficient data to support or refute the influence of HBOT in decreasing morbidity and mortality rates. concluded no significant difference in LOS between patients treated with HBOT to those who were not [24].…”

“…In regard to cost-effectiveness, two independent literature reviews by Cianci and Struzyna concluded that HBOT in burns decreases the overall cost of therapy, and in the first review, a saving cost of $107,000 (36%) per patient was reported [22,24].…”

“…Moreover, Struzyna et al has demonstrated a similar conclusion in multiple clinical trials that concluded an improvement in mortality rates after the use of HBOT in comparison to the non-HBO treated group. Nevertheless, they also portray other contradicting trials that show insignificant and insufficient differences in the rates between the two groups [ 24 ]. Similarly, regarding morbidity and mortality, Weitgasser et al and Villanueva et al reviews have reported no clinical difference between the HBOT and non-HBOT groups [ 7 , 25 ].…”

“…However, a trial by Chiang et al reached the conclusion of an insignificant LOS between the HBOT and non-HBOT group, whether in the ICU (HBOT vs. control: 18.11 +/- 4.41 vs. 33.33 +/-14.13 days, p = 0.318) or hospital wards (HBOT vs. control: 77.92 +/- 6.61 vs. 70.21 +/-16.23 days, p = 0.600) [ 28 ]. In addition, a literature review published by Struzyna et al demonstrated multiple studies that concluded no significant difference in LOS between patients treated with HBOT to those who were not [ 24 ]. In regard to cost-effectiveness, two independent literature reviews by Cianci and Struzyna concluded that HBOT in burns decreases the overall cost of therapy, and in the first review, a saving cost of $107,000 (36%) per patient was reported [ 22 , 24 ].…”

Effects of hyperbaric oxygen therapy on the healing of thermal burns and its relationship with ICAM-1: A case-control study

“…The inhalation of 100% oxygen at pressures greater than sea level at 2.0–2.5 atm absolute (ATA) for 90–120 min, twice daily, is recommended by the Undersea & Hyperbaric Medical Society [ 9 ]. The effects of increased oxygen supply include angiogenesis, the inhibition of aerobic bacterial growth, increased fibroblast proliferation, increased leukocyte activity, reduced tissue edema, and vascular contraction, the last of which reduces stromal fluid transudation and the occurrence of edema [ 10 , 11 ].…”