The effect of hyperbaric oxygen on neuroregeneration following acute thoracic spinal cord injury

Dayan, Kamil; Keser, Ayşegül; Konyalιoğlu, Sibel; Erturk, M.; Aydin, Figen; Şengül, Gülgün; Dağcı, Taner

doi:10.1016/j.lfs.2011.12.005

Cited by 33 publications

(22 citation statements)

References 27 publications

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“…The effect of HBO treatment of acute SCI in clinical settings is controversial [3–5]. Our previous studies have shown that HBO treatment clinically accelerates the functional recovery in rats with SCI [19].…”

Section: Discussionmentioning

confidence: 99%

“…Neuronal cell membrane structures are rich in lipids, and research has found that lipid oxidation caused by free radicals has important implications on SCI outcome [1, 2]. While some studies into SCI treatment have found that hyperbaric oxygen (HBO) can reduce the generation of oxygen free radicals in the body, thus reducing the oxygen free radicals caused lipid oxidation and accelerating SCI repair, other studies found opposite results [3–5]. Therefore, HBO effect on nerve injury is yet to be elucidated.…”

Section: Introductionmentioning

confidence: 99%

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Hyperbaric oxygen treatment of spinal cord injury in rat model

et al. 2017

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BackgroundThe purpose of this study was to investigate the therapeutic effects and mechanisms of hyperbaric oxygen (HBO) treatment on rats following spinal cord injury (SCI).MethodsA total of 45 Sprague-Dawley (SD) rats were randomly divided into three groups. Sham-SCI group was surgically exposed but not subjected to the SCI procedure. SCI-control group was administered SCI and treated with regular air. SCI-HBO group was administered SCI and HBO treatment. Neuromotor functions were examined using the Basso, Beattie, and Bresnahan (BBB) locomotor rating scale and the inclined plane assessment at before SCI (baseline) and after SCI. Superoxide dismutase (SOD) activities and malondialdehyde (MDA) levels were measured.ResultsStarting from Day 1 after SCI but except Day 2, the SCI-HBO group has significantly higher BBB scores than the SCI-control group. After SCI, the maximum inclination angles at which rats could maintain were significantly lower in both SCI groups. But the maximum angles were significantly bigger for the rats in the SCI-HBO group than those on the SCI-control group at 5, 10 and 20 days after SCI. SOD activities in SCI-HBO rats were significantly higher and MDA levels were significantly lower than in SCI-control rats, at two and five days after SCI. There was also less cystic degeneration of spinal cord in SCI-HBO rats, compared to SCI-control rats.ConclusionsThese results suggest that HBO treatment has a therapeutic value in treating SCI. Increased oxygen free radical scavenging and reduced lipid oxidation may be one of the mechanisms.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Hyperbaric oxygen treatment of spinal cord injury in rat model

et al. 2017

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“…The overall effects of HBO are increased tissue oxygenation and metabolism in penumbral tissue [73][74][75][76]. The beneficial effects of HBO in spinal cord I/R injury could be related to reduced endothelial adhesion molecule expression, and improved collagen synthesis, angiogenesis, and epithelization, as well as to decreased neutrophil activation and migration.…”

Section: Hyperbaric Oxygen (Hbo) Therapymentioning

confidence: 99%

“…The beneficial effects of HBO in spinal cord I/R injury could be related to reduced endothelial adhesion molecule expression, and improved collagen synthesis, angiogenesis, and epithelization, as well as to decreased neutrophil activation and migration. Moreover, HBO stabilizes lysosomal enzymes and promotes NO production [73]. Wang et al implicated the induction of autophagy in neuroprotection by HBO [77].…”

Section: Hyperbaric Oxygen (Hbo) Therapymentioning

confidence: 99%

Current and emerging treatment options for spinal cord ischemia

Nardone

Pikija

Mutzenbach

et al. 2016

Drug Discovery Today

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“…Hyperbaric oxygen (HBO) is occasionally used as a prognosis therapy for the treatment of SCI. The beneficial effects of HBO in SCI stem from lower endothelial adhesion molecule expression and decreased neutrophil activation [11] . Moreover, HBO stabilizes metabolism, improves angiogenesis and collateral circulation which enhance the focal area recovery [12,13].…”

Section: Introductionmentioning

confidence: 99%