Hyperbaric oxygen treatment of spinal cord injury in rat model

Sun, Yongming; Liu, Dong; Wang, Qingpeng; Su, Peng; Tang, Qi-Feng

doi:10.1186/s12883-017-0909-z

Cited by 14 publications

(11 citation statements)

References 15 publications

(19 reference statements)

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“…The number of HBO sessions used in clinical medicine has not been firmly standardized as it substantially depends on the given medical condition; it could range from several to 60 sessions (Mathieu et al 2017). In animal experiments, the number of HBO exposures usually ranges between 1 and 15 (Ay et al 2007, Ding et al 2017, Limirio et al 2018, Sun et al 2017; studies on HBO impact on ex vivo models using various cell types usually report from 1 to 7 HBO exposures (Kang et al 2004) and document that the effect of treatment is detectable even after a single exposure. For our experiments we have thus selected conditions mimicking chronic HBO treatment on the cellular model.…”

Section: Discussionmentioning

confidence: 99%

“…It has been well documented that ROS production increases in HBO conditions, although oxidative susceptibility varies with the cell type, parameters of HBO therapy and number of exposures (Jang et al 2018, Simsek et al 2011. Literature data on SOD activity in HBO-treated subjects frequently document its increase going either in parallel with elevated ROS production and markers of oxidative stress (Simsek et al 2011) or fully compensating for oxidative damage (Sun et al 2017).…”

Section: Discussionmentioning

confidence: 99%

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Repeated Exposure to Hyperbaric Hyperoxia Affects Mitochondrial Functions of the Lung Fibroblasts

Dejmek

Kohoutová²,

Kripnerová³

et al. 2018

Physiol Res

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Hyperbaric oxygen (HBO) therapy, i.e. breathing pure oxygen under increased environmental pressures serves as a treatment for diverse medical conditions. However, elevated oxygen concentration can be detrimental to central nervous system or lungs. Our study aimed to evaluate the effects of repeated exposure to HBO on mitochondrial respiration assessed by high-resolution respirometry (HRR), cell viability estimated by PrestoBlue® reaction, morphology analyzed by routine phase contrast and fluorescent microscopy, and superoxide dismutase (SOD) and citrate synthase (CS) activities using human lung fibroblasts. The cells were exposed to HBO for 2 h per day for 5 consecutive days. One day after the last exposure, HBO cells displayed significantly smaller area and perimeter, compromised viability and elevated SOD activity. No changes were detected in CS activity or quality of mitochondrial network. HRR revealed impaired mitochondrial oxygen consumption manifested by increased leak respiration, decreased activity of complex II and compromised ATP-related oxygen consumption when fatty acids were oxidized. Our findings document that in conditions mimicking chronic intermittent exposure to HBO, lung fibroblasts suffer from compromised mitochondrial respiration linked to complex II and impaired cellular growth in spite of increased antioxidant defense. Underlying mechanism of this HBO-induced mitochondrial dysfunction should be further explored.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Repeated Exposure to Hyperbaric Hyperoxia Affects Mitochondrial Functions of the Lung Fibroblasts

Dejmek

Kohoutová²,

Kripnerová³

et al. 2018

Physiol Res

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“… 44 Results of another study which was investigated the mechanisms of HBOT following SCI, suggested that reducing lipid oxidation and oxygen free radicals is one of the mechanisms. 45 Sun et al 46 documented that HBO significantly improved the recovery of neuronal function and fractional anisotropy compared to SCI group on days 7, 14, and 21 after SCI. Recently, it was documented that HBOT improves neurological disorders by amelioration of apoptosis and suppressing dendritic/synaptic degeneration through upregulating the brain-derived neurotrophic factor (BDNF)/tropomyosin receptor kinase B signaling pathways in the anterior horn of spinal cord after SCI.…”

Section: N V Ivo S Tudiesmentioning

confidence: 99%

A review on the neuroprotective effects of hyperbaric oxygen therapy

Ahmadi

Khalatbary

2021

Med Gas Res

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Hyperbaric oxygen therapy, intermittent breathing of 100% oxygen at a pressure upper than sea level, has been shown to be some of the neuroprotective effects and used therapeutically in a wide range of neurological disorders. This review summarizes current knowledge about the neuroprotective effects of hyperbaric oxygen therapy with their molecular mechanisms in different models of neurological disorders.

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“…Utilizing a rodent model of TBI, HBOT initiated at 3 h after cortical deformation induction attenuated symptoms after histopathological analysis [ 59 ]. Another murine model of TBI offered evidence that HBOT-induced cognitive and learning regenerative abilities were preserved from 3 h after injury to 7 days [ 13 ]. While experimental protocols, such as therapeutic windows, may vary, HBOT consistently provides neuroprotection for acute TBI [ 60 ].…”

Section: Implications Of Hbot In Other Neurological and Non-neurolmentioning

confidence: 99%

“…This suggests that similar mechanisms of HBOT can be demonstrated with lower tensions of oxygen. Additionally, HBOT has also proven beneficial in the treatment of other pathological diseases, including traumatic brain injury (TBI), spinal cord injury (SCI), and stroke [ 13 ]. Currently, there are few treatment options available for many neurological diseases; however, experimental studies utilizing HBOT demonstrate promising results.…”

Section: Introductionmentioning

confidence: 99%

An Extra Breath of Fresh Air: Hyperbaric Oxygenation as a Stroke Therapeutic

et al. 2020

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Stroke serves as a life-threatening disease and continues to face many challenges in the development of safe and effective therapeutic options. The use of hyperbaric oxygen therapy (HBOT) demonstrates pre-clinical effectiveness for the treatment of acute ischemic stroke and reports reductions in oxidative stress, inflammation, and neural apoptosis. These pathophysiological benefits contribute to improved functional recovery. Current pre-clinical and clinical studies are testing the applications of HBOT for stroke neuroprotection, including its use as a preconditioning regimen. Mild oxidative stress may be able to prime the brain to tolerate full extensive oxidative stress that occurs during a stroke, and HBOT preconditioning has displayed efficacy in establishing such ischemic tolerance. In this review, evidence on the use of HBOT following an ischemic stroke is examined, and the potential for HBOT preconditioning as a neuroprotective strategy. Additionally, HBOT as a stem cell preconditioning is also discussed as a promising strategy, thus maximizing the use of HBOT for ischemic stroke.

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Hyperbaric oxygen treatment of spinal cord injury in rat model

Cited by 14 publications

References 15 publications

Repeated Exposure to Hyperbaric Hyperoxia Affects Mitochondrial Functions of the Lung Fibroblasts

Repeated Exposure to Hyperbaric Hyperoxia Affects Mitochondrial Functions of the Lung Fibroblasts

A review on the neuroprotective effects of hyperbaric oxygen therapy

An Extra Breath of Fresh Air: Hyperbaric Oxygenation as a Stroke Therapeutic

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