A review on the neuroprotective effects of hyperbaric oxygen therapy

Ahmadi, F; Khalatbary, Ali Reza

doi:10.4103/2045-9912.311498

Cited by 16 publications

(5 citation statements)

References 174 publications

(181 reference statements)

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“…HBO therapy is used to treat diseases by inhaling pure oxygen in an environment above atmospheric pressure. In recent years, studies both at home and abroad have shown that HBO has a good therapeutic effect on DOC, which can improve the GCS, CNPVSS, and GOS scores of patients with DOC with different etiologies, improve their prognosis, and shorten coma times (Ahmadi & Khalatbary, 2021 ; Joshua et al., 2022 ; Y. S. Liu, Liu, et al., 2022 ; M. Liu, Li, et al., 2022 ; S. Y. Zhang et al., 2017 ). In this study, we analyzed patients with DOC who had been treated over the past 10 years.…”

Section: Discussionmentioning

confidence: 99%

Analysis of the efficacy of hyperbaric oxygen therapy for disorders of consciousness: A retrospective cohort study

Li,

Di,

Liu

et al. 2024

Brain and Behavior

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ObjectiveTo analyze the efficacy and associated factors affecting the prognosis in patients with disturbance of consciousness after hyperbaric oxygen (HBO) treatment.MethodsA retrospective study was carried out on patients with disorders of consciousness (DOC) receiving HBO treatment from January to January 2022 in the Second Department of Rehabilitation Medicine of the Second Hospital of Hebei Medical University, China.ResultsHBO therapy improved the Glasgow Coma Scale (GCS) and Chinese Nanjing Persistent Vegetative State Scale (CNPVSS), as well as the clinical efficacy in patients with DOC. The comparison of GCS and CNPVSS scores in patients with DOC before and after HBO treatment was all statistically significant, with 325 patients (67.1%) showing effective results and 159 patients (32.9%) having unchanged outcomes. Univariate analysis indicated that there were statistically significant differences in age, HBO intervention time, HBO treatment times, pre‐treatment GCS score, and etiology and underlying diseases between the good and poor prognoses groups. Multivariate regression analysis showed that HBO intervention time ≤7 days, HBO treatment ＞ times, high GCS score before HBO treatment, and brain trauma were independent influencing factors in achieving a good prognosis for patients with DOC. Low pre‐treatment GCS scores were an independent risk factor for a poor prognosis in patients with brain trauma while being male, late HBO intervention time, fewer HBO treatment times, and low pre‐treatment GCS scores were independent risk factors for a poor prognosis in patients with DOC after a stroke. Being ≥50 years of age, late HBO intervention time, and low pre‐treatment GCS scores were independent risk factors for a poor prognosis in patients with DOC after hypoxic‐ischaemic encephalopathy.ConclusionHBO therapy can improve the GCS, CNPVSS scores and clinical efficacy in patients with DOC, and the timing of HBO intervention ≤7 days, times of HBO treatment, high pre‐treatment GCS score, and brain trauma were the independent influencing factors of good prognosis in patients with DOC.

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Section: Discussionmentioning

confidence: 99%

Analysis of the efficacy of hyperbaric oxygen therapy for disorders of consciousness: A retrospective cohort study

Li,

Di,

Liu

et al. 2024

Brain and Behavior

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“…Some studies report that hyperbaric oxygen therapy has a neuroprotective effect in the treatment of neurological injuries [22]. Therefore, we also used hyperbaric oxygen therapy for nerve injuries.…”

Section: Discussionmentioning

confidence: 99%

The 2023 Turkey Earthquake: Management of 627 Pediatric Musculoskeletal Injuries in the First Month

Uluöz,

Gökmen

2023

Children

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(1) Background: On 6February 2023, two consecutive earthquakes hit Kahramanmaraş and surrounding ten cities, killing over 50,000 people. We aimed to reveal the treatment process of pediatric patients admitted to Adana City Hospital (ACH) in the first month after the earthquake. (2) Methods: Demographic data of the patients, time of presentation to the emergency department, injury locations, treatment procedures, and patient file information were recorded retrospectively and evaluated statistically. (3) Results: There were 1246 patients under the age of 18. A total of 560 patients were hospitalized in the orthopedic clinic; 42% were admitted in the first 24 h and 58% in the first three days. Of these children, 69 (12%) were referred, 52 (10%) were transferred to other departments within the hospital, and 421 (75.2%) were discharged in stable condition. The number of patients with large bone fractures was 77 (34 open fractures). Fasciotomy surgery was performed on 131 patients, 78 of whom had bilateral procedures. Of the 31 patients who underwent amputation, 17 (55%) were performed within the first 24 h and 28 (90%) within the first week. (4) Conclusions: Almost all injured children are admitted to the hospital during the first few days after an earthquake. The management of earthquake injuries in pediatric patients requires specialized care and immediate attention during the treatment process.

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“…[12] Тип ушкодження (за AOSpine): ушкодженні СМ. Крім того, низка експериментальних досліджень дала змогу виявити інші потенційні механізми нейропротекторного ефекту ГБО [13,14]: 1) пригнічення апоптозу, 2) зменшення оксидантного стресу, 3) зменшення запалення, 4) стимулювання ангіогенезу, 5) зменшення набряку спинного мозку, 6) посилення автофагії тощо. Апоптоз -це форма запрограмованої загибелі клітин, яка спостерігається при різних захворюваннях і патологічних станах, зокрема при травматичних ушкодженнях СМ.…”

Section: обговоренняunclassified

Hyperbaric oxygenation therapy in treatment of traumatic spinal cord injury: a pilot study

Nekhlopochyn¹,

Voronov²,

Verbov³

2021

Ukr Neurosurg J

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Spinal cord traumatic injury as resulting persistent movement and sensory disorders is one of the most disabling consequences of traumatic factor impact on the human body. Despite a large number of experimental and clinical studies aimed at developing methods for restoring lost functions, there is no acceptable solution to the problem. One of the promising areas in the treatment and rehabilitation of this category of patients is the use of hyperbaric oxygenation (HBO). Experimental models have shown that HBO has a neuroprotective effect in spinal cord injury, but the results of clinical application of the method are still controversial. Objective: to determine the effectiveness of HBO in the complex therapy of victims with traumatic spinal cord injury and the feasibility of further study of this area. Materials and Methods: Study design is a pilot observational retrospective “case – control”. The database of patients with spinal cord injury who were hospitalized at Romodanov Neurosurgery Institute in the period from 2010 to 2020 were used for the analysis. When selecting a control for each clinical case, the following factors were considered: gender, age, circumstances of injury, type of damage to the osteoligamentous apparatus, level of neurological deficit, degree of damage and compression of the spinal cord, time elapsed from the moment of injury to surgery. 28 "case ‒ control" pairs were analyzed. The main criterion for therapy effectiveness was the change in the functional class according to the ASIA scale. Results. Positive dynamics was registered in 57% of victims, including in the group of patients receiving HBO therapy - in 71%, in the control group - in 43%. HBO therapy in the postoperative period significantly affects the dynamics of regression of neurological disorders (p=0.0295). The odds ratio is 3.333 (95% confidence interval - 1.098‒10.116, p=0.0335). The calculation of the odds ratio, adjusted for additional analyzed factors, showed a more pronounced efficiency - 4.519 (95% confidence interval - 1.279‒15.962, p=0.0192). Conclusions. The obtained results indicate that usage of HBO as a method of complex therapy for traumatic spinal cord injury is promising for further study in order to determine the effectiveness of the method, the optimal timing of treatment initiation in the postoperative period and its duration.

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A review on the neuroprotective effects of hyperbaric oxygen therapy

Cited by 16 publications

References 174 publications

Analysis of the efficacy of hyperbaric oxygen therapy for disorders of consciousness: A retrospective cohort study

Analysis of the efficacy of hyperbaric oxygen therapy for disorders of consciousness: A retrospective cohort study

The 2023 Turkey Earthquake: Management of 627 Pediatric Musculoskeletal Injuries in the First Month

Hyperbaric oxygenation therapy in treatment of traumatic spinal cord injury: a pilot study

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