The effect of hyaluronic acid and phospholipid based lubricants on friction within a human cartilage damage model

Forsey, Richard W.; Fisher, John; Thompson, Jonathan; Stone, Martin; Bell, Carol; Ingham, Eileen

doi:10.1016/j.biomaterials.2006.04.018

Cited by 124 publications

(126 citation statements)

References 25 publications

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“…For example, shear flow activated von Willebrand factor to partially unfold and triggers wound-healing process. [30] In addition, friction between articular cartilages results in osteoarthritis [31].…”

Section: Friction On Biomolecular Filmmentioning

confidence: 99%

Direct Observation of Amyloid Nucleation under Nanomechanical Stretching

et al. 2013

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Self-assembly of amyloid nanofiber is associated with functional and pathological processes such as in neurodegenerative diseases. Despite intensive studies, stochastic nature of the process has made it difficult to elucidate molecular mechanisms for the key amyloid nucleation. Here, we investigated the amyloid nucleation of silk-elastinlike peptide (SELP) using time-lapse lateral force microscopy (LFM). By repeated scanning a single line on a SELP-coated mica surface, we observed sudden stepwise height increases, corresponds to nucleation of an amyloid fiber. The lateral force profiles followed either a worm-like chain model or an exponential function, suggesting that the atomic force microscopy (AFM) tip stretches a single or multiple SELP molecules along the scanning direction, serves as the template for further selfassembly perpendicular to the scan direction. Such mechanically induced nucleation of amyloid fibrils allows positional and directional control of amyloid assembly in vitro, which we demonstrate by generating single nanofibers at predetermined nucleation sites.

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Section: Friction On Biomolecular Filmmentioning

confidence: 99%

Direct Observation of Amyloid Nucleation under Nanomechanical Stretching

et al. 2013

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“…It is one of the most common disorders of musculoskeletal system, which affect nearly 70 % of 70 year olds (Forsey, 2006). Surface of cartilage shows arear of softening, fibrillations or erosions.…”

Section: Introductionmentioning

confidence: 99%

“…Addition of hyaluronic acid to basic solution -PBS (Bell, 2006) or Ringers solution (Forsey, 2006) Svratka, Czech Republic, May 14 -17, 2018 Paper #320, pp. 709-712, doi: 10.21495/91-8-709 important.…”

Section: Introductionmentioning

confidence: 99%

Optoelectronic measurement of interfacial surface

2018

Engineering Mechanics

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“…One of the common therapies used in the early and mild stages of the disease are intraarticular injections with hyaluronic acid (HA) [5]. Studies revealed that HA leads to a positive and beneficial change within the affected joint by its mechanic effect (lubrication), its chondroprotective mechanism and by acting as a cytokine and anti-inflammatory mediator in the synovial fluid [6][7][8][9]. It is also considered that viscosupplementation with hyaluronic acid based products may reduce the time to total knee arthroplasty for up to 8.7 months [10].…”

Section: Introductionmentioning

confidence: 99%

Changes in Knee Joint Space Width in Treatment with a New Hyaluronic-Based Hydrogel

Russu

Feier

Pop

et al. 2017

Acta Medica Marisiensis

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Objective: Our purpose was to assess the effect of a new hyaluronic acid-based (Hymovis®) injections on joint space width narrowing in patients diagnosed with knee osteoarthritis. Methods: A prospective clinical trial was conducted in the Department of Orthopedics and Traumatology II from the Clinical County Hospital, Tîrgu Mureș, Romania. Thirty-five patients diagnosed with idiopathic knee osteoarthritis received two intraarticular injections with hyaluronic acid-based hydrogel (24 mg of hyaluronic acid/3 ml) at one-week interval. Anteroposterior radiographs were obtained before the injections, at six and twelve months after. Minimum joint space width was measured by two senior orthopaedics surgeons at each follow up. Each radiograph was measured again by the same evaluators two weeks apart. Results: Thirty-one patients were present at the final follow-up. A minor reduction in mean weight was noticed (from 82.2 kg ± 16.2 kg to 80.9 kg ± 16.0, p > 0.398) without any correlation with joint space width narrowing. There were no major changes at the first follow up (6 months) regarding joint space narrowing. A reduction in joint space width was observed however at 12 months varying from 4.4 mm (SD ± 1.64, range 1.8-7.1) at the first assessment to 4.3 mm (SD ± 1.26, range 0.0-6.8) at the final follow-up but with no statistical difference (p=0.237). Conclusion: No significant modification in joint space width at the final follow-up secondarily proved that two injections of Hymovis® may slow down narrowing in the knee joint space over a one-year period.

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The effect of hyaluronic acid and phospholipid based lubricants on friction within a human cartilage damage model

Cited by 124 publications

References 25 publications

Direct Observation of Amyloid Nucleation under Nanomechanical Stretching

Direct Observation of Amyloid Nucleation under Nanomechanical Stretching

Optoelectronic measurement of interfacial surface

Changes in Knee Joint Space Width in Treatment with a New Hyaluronic-Based Hydrogel

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