The Effect of Hyaluronic Acid on the Periodontium in Spontaneous Periodontitis in Rats

Копчак, О.В.; Марченко, Наталья Сергеевна; Kaniura, Oleksandr; Savosko, Serhii I; Yanishevsky, Konstyantyn A; Makarenko, Olexandr; Дорошенко, О. М. Дорошенко Т. М. Волосовець М. В.; Asharenkova, Olha V

doi:10.4067/s0717-95022021000401028

Cited by 2 publications

(2 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…When chronic periodontitis is accompanied by inflammation or an inflammatory–dystrophic process, hyaluronidases produced by microorganisms determine the breakdown of HA. As a result, the use of external HA to repair the periodontium was suggested by Kopchak and coworkers [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

Efficiency of Hyaluronic Acid in Infrabony Defects: A Systematic Review of Human Clinical Trials

et al. 2022

View full text Add to dashboard Cite

Background and objectives: The aim of this systematic review was to assess the electronic literature about the benefits of using hyaluronic acid (HA) in the surgical periodontal treatment of infrabony defects. Materials and methods: This review was conducted under the PRISMA guidelines. The electronic search was conducted on PubMed, Scopus, Web of Science, and Cochrane databases until February 2022. The inclusion criteria consisted of human clinical trials that reported the use of HA in open-flap debridement (OFD) for infrabony defects. The assessment of risk of bias was performed using the Cochrane risk of bias tool. Statistical analysis was performed using Review Manager. Results: Overall, three RCTs were found eligible for the statistical analysis. Probing depth (PD) reduction and clinical attachment level (CAL) gain in the HA test group presented WMs of −1.11 mm (95% CI −2.38 to 0.16 mm; p = 0.09) and −1.38 mm (95% CI −2.26 to −0.49 mm; p = 0.002), respectively. However, the heterogeneity of the RCTs was high, and the risk of bias, in general, was low. Conclusions: The use of hyaluronic acid seems to have beneficial effects in periodontal surgery using OFD, in terms of PD and CAL. To draw a clear conclusion, more adapted and well-designed clinical trials are needed to assess the advantage of this product in comparison with other products.

show abstract

Section: Introductionmentioning

confidence: 99%

Efficiency of Hyaluronic Acid in Infrabony Defects: A Systematic Review of Human Clinical Trials

et al. 2022

View full text Add to dashboard Cite

show abstract

“…At the same time, in most cases remedial measures have low efficiency, since the therapeutic effect is temporary and the prophylactic action is absent [6]. Moreover, traditional treatment methods are mainly oriented on stabilizing the disease, and not on regenerating destructed periodontal tissues [7].…”

mentioning

confidence: 99%

Current regenerative approaches to the treatment of generalized periodontitis in young people (literature review)

Kopchak,

Kovach,

Litvinova

et al. 2024

Med. perspekt.

View full text Add to dashboard Cite

Periodontal diseases are a component of the global burden of chronic morbidity worldwide. The prevalence of periodontitis increases with age, reaching a high at the age of 40, which has increased medical and social importance. In Ukraine the prevalence of periodontal diseases among people aged 19-24 reaches 30%, 25-30 years – more than 60%, and in the age group 35-44 years and older – varies from 92 to 98%. With the generalized form of periodontitis in young people, considerable degradation of periodontal tissues occurs, while treatment measures are mainly ineffective, with a temporary therapeutic effect that only stabilizes the course of disease. The goal of this literature review was to identify innovative approaches to the reparation and regeneration of affected periodontal tissues that could be used as non-invasive treatment modes. The conducted analysis included studies whose findings were published in 52 English- and Ukrainian-language information sources for the period 1985-2022. The literature search was carried out in the PubMed, Scopus, Google Scholar databases and in the electronic catalog of the National Scientific Medical Library of Ukraine. The results of the literature review confirm the considerable potential of cell therapy supplemented with platelet-rich plasma for the formation of new periodontal tissues, which supported their use to promote the regenerative process. In combination with stem cells, platelet-rich plasma provides a considerable increase in the effectiveness of periodontal disease treatment in young people. The literature search was carried out in PubMed databases (327 sources), Scopus (121 sources), Google Academy (16 articles) and in the electronic catalog of the National Scientific Medical Library of Ukraine (89 records). Out of 537, 52 sources were selected for review. Periodontal tissue disease is an actual problem today. According to the data of the analyzed literature, the use of stem cells in dentistry is actively studied, but there are no recommendations and protocols for their use in periodontology. The analyzed scientific sources, the results of which were published in English- and Ukrainian-language sources, aimed at tissue regeneration, have a significant impact on the creation of new approaches to the treatment of generalized periodontitis. The world experience of using cellular technologies with using stem cells demonstrates the significant potential and positive results of their application to promote the regenerative process in the comprehensive treatment of periodontal diseases. The combination of stem cells and platelet-enriched plasma significantly increases the effectiveness of treatment of periodontal tissue diseases, in particular generalized periodontitis in young people. The use of stem cells and growth factors, which contains platelet-rich plasma, allows you to significantly increase the effectiveness of periodontal disease treatment.

show abstract

The Effect of Hyaluronic Acid on the Periodontium in Spontaneous Periodontitis in Rats

Cited by 2 publications

References 20 publications

Efficiency of Hyaluronic Acid in Infrabony Defects: A Systematic Review of Human Clinical Trials

Efficiency of Hyaluronic Acid in Infrabony Defects: A Systematic Review of Human Clinical Trials

Current regenerative approaches to the treatment of generalized periodontitis in young people (literature review)

Contact Info

Product

Resources

About