Efficiency of Hyaluronic Acid in Infrabony Defects: A Systematic Review of Human Clinical Trials

Onişor, Florin; Bran, Simion; Meşter, Alexandru; Voina-Tonea, Andrada

doi:10.3390/medicina58050580

Cited by 5 publications

(7 citation statements)

References 32 publications

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“…A similar significant reduction of PPD was observed in the subgroup analysis at 6 months (1.28 mm), 12 months (0.89 mm) and 24 months (0.85 mm) of therapy with HA compared to the control group in patients with infrabony defects. This was in line with the findings reported by Onsior et al [9]. In which, they have reported a 1.11 mm PPD reduction in HA treated group compared to the open flap detriment.…”

Section: Discussionsupporting

confidence: 93%

“…A similar CAL gain was observed in the subgroup analysis at 6 months (0.94mm), 12 months (1.52mm) and 24 months (0.57mm) of the management. Similar findings were recorded by the meta-analysis conducted by Onsior et al [9] and Eliezer et al [8], where they recorded a 1.38 mm and 0.85 mm CAL gain in the HA group compared to surgery, respectively.…”

Section: Discussionsupporting

confidence: 88%

“…However, high heterogeneity and risk of bias were the limitations of the studies. Another meta-analysis by Onisor et al [9] from a limited number of studies recorded a significant increase in CAL gain and non-significant PPD reduction with adjuvant HA administration compared to the open-flap debridement.…”

Section: Introductionmentioning

confidence: 98%

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Clinical and Radiological Benefits of Hyaluronic Acid in Periodontal Infrabony Defects: A Systematic Review and Meta-analysis

Aldahlawi¹

2023

TODENTJ

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Purpose: There is no consensus on the clinical and radiological benefits of hyaluronic acid (HA) in patients with periodontitis having infrabony defects. Hence, this study examined the effects of HA in periodontitis patients with infrabony defects through a comprehensive systematic review process. Methodology: A systematic literature search was performed using PubMed/Medline, Scopus, Embase and Cochrane Library from inception to March 2022. Randomized or non-randomized clinical trials and single-arm clinical trials that assessed the clinical and radiological benefits of HA in periodontitis patients with infrabony defects with a minimum of 6 months follow-up were included in this study. Surgical regenerative therapy was considered as the comparator. The Cochrane risk of bias assessment tool and Downs and Black checklist was used for the quality assessment of randomized and non-randomized interventional studies, respectively. A subgroup and sensitivity analyses were performed to explore the heterogeneity and robustness of the findings, respectively. Results: A total of 13 out of 725 studies were included in this systematic review, of which 9 were considered for meta-analysis. The meta-analysis indicated significant benefits of HA in terms of reduction in probing pocket depth (SMD: 1.12 mm; 95% CI: 0.60-1.65; 9 studies), bone defect depth (SMD: 1.04mm; 95%CI: 0.62-1.47; 3 studies) and gain in clinical attachment level (1.04 mm; 95% CI: 0.33-2.47; 8 studies). Overall, the quality of included studies was good. Conclusion: The current evidence indicates that the administration of HA in the periodontal regenerative treatment of infrabony defects was significantly effective in increasing clinical attachment levels and reducing probing pocket and bone defect depth.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 88%

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Clinical and Radiological Benefits of Hyaluronic Acid in Periodontal Infrabony Defects: A Systematic Review and Meta-analysis

Aldahlawi¹

2023

TODENTJ

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“…[ 216 ] Scientific evidence supports the topical application of these gels for treating gingivitis, and for non‐surgical and surgical periodontitis treatment. [ 207 , 210 , 217 , 218 , 219 ]…”

Section: Review Of Regenerative Products In Periodontal Regenerationmentioning

confidence: 99%

From Basic Science to Clinical Practice: A Review of Current Periodontal/Mucogingival Regenerative Biomaterials

De Lauretis,

Øvrebø,

Romandini

et al. 2024

Advanced Science

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Periodontitis is a dysbiosis‐driven inflammatory disease affecting the tooth‐supporting tissues, characterized by their progressive resorption, which can ultimately lead to tooth loss. A step‐wise therapeutic approach is employed for periodontitis. After an initial behavioral and non‐surgical phase, intra‐bony or furcation defects may be amenable to regenerative procedures. This review discusses the regenerative technologies employed for periodontal regeneration, highlighting the current limitations and future research areas. The search, performed on the MEDLINE database, has identified the available biomaterials, including biologicals (autologous platelet concentrates, hydrogels), bone grafts (pure or putty), and membranes. Biologicals and bone grafts have been critically analyzed in terms of composition, mechanism of action, and clinical applications. Although a certain degree of periodontal regeneration is predictable in intra‐bony and class II furcation defects, complete defect closure is hardly achieved. Moreover, treating class III furcation defects remains challenging. The key properties required for functional regeneration are discussed, and none of the commercially available biomaterials possess all the ideal characteristics. Therefore, research is needed to promote the advancement of more effective and targeted regenerative therapies for periodontitis. Lastly, improving the design and reporting of clinical studies is suggested by strictly adhering to the Consolidated Standards of Reporting Trials (CONSORT) 2010 statement.

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“…Infrabony defects are a result of progressive periodontitis because of local factors (e.g. ), plaque accumulation, food debridement, tooth position, occlusal trauma) [5].…”

Section: Introductionmentioning

confidence: 99%

Comparison of Xenograft and Alloplast Bone Grafts for Infrabony Bone Defect: Literature Review

Nurcahyanti,

Amalia

2023

J. Food Pharm. Sci

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Restoring supporting tissues to a healthy state is a critical area that provides a much more appealing beside prevention, initial therapy, and corrective procedure. Infrabony defects can be found in the interalveolar and marginal bone caused by periodontal disease as a result of local factors. Nowadays, various surgical therapies are available for treating infrabony defects such as bone graft. However, many considerations in selecting the best option of bone graft materials. To compare the effectiveness of Xenograft and Alloplast bonegraft in infrabony defect therapy. The allograft presented a significantly higher amount of newly formed bone than the xenograft. There were no differences in the percentage of newly formed bone between the allograft and the alloplastic graft, and between the alloplastic graft and the xenograft. Between the three types of grafts, there were no discernible changes in the percentage of remaining particles. All bone substitute materials shown favorable properties for use in bone regeneration treatments. Local factors such as oral hygiene and controlled chronic disease are the main point of successful bone graft therapy. The present study concludes that both Alloplast and Xenograft have equal potential in infrabony bone defect therapy.

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Efficiency of Hyaluronic Acid in Infrabony Defects: A Systematic Review of Human Clinical Trials

Cited by 5 publications

References 32 publications

Clinical and Radiological Benefits of Hyaluronic Acid in Periodontal Infrabony Defects: A Systematic Review and Meta-analysis

Clinical and Radiological Benefits of Hyaluronic Acid in Periodontal Infrabony Defects: A Systematic Review and Meta-analysis

From Basic Science to Clinical Practice: A Review of Current Periodontal/Mucogingival Regenerative Biomaterials

Comparison of Xenograft and Alloplast Bone Grafts for Infrabony Bone Defect: Literature Review

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