The Effect of Hyaluronan on Bone and Soft Tissue and Immune Response in Wound Healing

Abstract

The observed difference in bone height between test and control sites in the surgical group after 12 months was less than 1 mm, which was only detectable on radiographs. No statistical difference was found on radiographs in the non-surgical group, where a decrease in bone height was found for both groups after scaling. Probing depth reduction after the surgical treatment, as well as after scaling and root planing, was as expected. Hyaluronan in contact with bone and soft tissues had no influence on the immune system in this study. Further studies are needed to determine the extent to which hyaluronan can lead to clinically significant healing of periodontal lesions.

Hyaluronic Acid as an Adjunct to Scaling and Root Planing in Chronic Periodontitis. A Randomized Clinical Trail

“…No statistical difference was found clinically or on radiographs in the non surgical groups. Mean probing depth reduced in both the groups, The authors concluded that Hyaluronon in contact with bone and soft tissue had no influence on immune system [29].…”

Effect of hyaluronic acid on morphological changes to dentin surfaces and subsequent effect on periodontal ligament cell survival, attachment, and spreading

“…In addition, the anti-inflammatory effect of HA applied as an adjunct to the conventional periodontitis therapy scheme in dentistry has been discussed [16]. In vitro studies have demonstrated that HA-induced reduction of periodontal pathogens including Actinobacillus actinomycetemcomitans (AAC) and Porphyromonas gingivalis (P.g.)…”

Assessment of Improvement of Gingivitis During Orthodontic Treatment Using Two Types of Toothpaste

“…The authors concluded that Hyaluronon in contact with bone and soft tissue had no influence on immune system. (23) Parodontax ® also promoted a statistically significant reduction in PD when compared to control group, the anti-inflammatory effect achieved in this group may be contributed to the herbal supplements in the toothpaste and their physiological properties. In this regard chamomile contains salicylic acid in the form of a methyl ester, which is an anti-inflammatory agent.…”