The effect of hormone replacement therapy on mood and everyday memory in younger mid-life women

Stephens, Christine; Pachana, Nancy A.; Bristow, Virginia

doi:10.1080/13548500600678180

Cited by 5 publications

(3 citation statements)

References 36 publications

(46 reference statements)

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“…More specifically, major depression is reported to involve dysfunction of the amygdala and hippocampus (Gotlib & Hamilton, 2008; Hamilton & Gotlib, 2008), anatomic structures found in the present study to differ volumetrically with pubertal stage. Hormone replacement therapy has neuroprotective effects on both mood and brain anatomy, suggesting that sex-steroid mechanisms play a role in mood (Ha et al, 2007; Stephens et al, 2006). …”

Section: Discussionmentioning

confidence: 99%

Pubertal stage and brain anatomy in girls

et al. 2012

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Studies of puberty have focused primarily on changes in hormones and on observable physical bodily characteristics. Little is known, however, about the nature of the relation between pubertal status and brain physiology. This is particularly important given findings that have linked the onset of puberty with both changes in cognitive functioning and increases in the incidence of depression and anxiety. The present study examined relations between pubertal stage, as assessed by Tanner Staging, and brain anatomy in a sample of 54 girls aged 9 - 15 years. Brain morphometric analysis was conducted using high-resolution magnetic resonance imaging (MRI). The hippocampus and amygdala were manually traced on MRI scans in all participants. Stepwise regression analyses were conducted with total intracranial volume (ICV), age, and pubertal status as the predictor variables and hippocampus and amygdala volumes as outcome variables. Pubertal status was significantly associated with left amygdala volume, after controlling for both age and intracranial volume (ICV). In addition, puberty was related to right hippocampus and amygdala volumes, after controlling for ICV. In contrast, no significant associations were found between age and hippocampal and amygdala volumes after controlling for pubertal status and ICV. These findings highlight the importance of the relation between pubertal status and morphometry of the hippocampus and amygdala, and of limbic and subcortical structures that have been implicated in emotional and social behavior.

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Section: Discussionmentioning

confidence: 99%

Pubertal stage and brain anatomy in girls

et al. 2012

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“…Sus hallazgos sugieren que los estrógenos tienen un efecto protector en el envejecimiento, facilitando los procesos cognitivos. En población posmenopáusica, también se ha encontrado mejoría en la ejecución de tareas de secuencia manual, velocidad perceptual (Kimura & Hampson, 1993) y mejoras en funciones ejecutivas como: la memoria verbal (Stephens, Pachana & Bristow, 2006;Shaywitz, Naftolin, Zelterman, Marchione, Holahan, Palter & Shaywitz, 2003), la lectura oral (Shaywitz et al, 2003), la fluidez verbal (Grodstein, Manson, Colditz, Willett, Speizer & Stampfer, 2000) y la inhibición (Marinho, Soares, Santiago, Maganhin, Machado, de Miranda Cota & Baracat, 2008). Sin embargo, esta mejoría no se presenta en la habilidad espacial (Kimura & Hampson, 1993) como es de esperarse, ya que es una tarea que se observa de mejor forma en los hombres.…”

Section: Efectos De Los Niveles Oscilantes De Hormonas Sobre La Cogniunclassified

Perfil neuropsicológico en transexuales: efecto del tratamiento de reasignación de sexo

Calderón¹,

Shejet²,

Pascual³

et al. 2011

Rev. chil. neuropsicol.

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“…10,11]. It has been shown in animal studies that adding progesterone may reverse some of the beneficial effects of estrogen on neural functioning [12].…”

Section: Introductionmentioning

confidence: 99%

The relationship between hormone replacement therapy (HRT) and memory performance in women: influences of HRT type and APOE E4 allele status

Spooner

Khoo³

et al. 2014

IJCNMH

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Objective: To investigate the relationship between hormone replacement therapy (HRT) and performance on the Wechsler Memory Scale-III (WMS-III) after controlling for confounders, and to determine the impact of different types of HRT and the effect of APOE ε4 allele status on memory performance. Methods:A sample of 223 postmenopausal women aged 44-80 years enrolled in the Longitudinal Assessment of Women (LAW) study participated in this study. Participants were administered tests of verbal memory, auditory memory, visual memory, attention and working memory from the WMS-III. Information on their HRT use, and a range of demographic and health variables were also collected. Results:After controlling for covariates, HRT use contributed unique variance to performance on the Spatial Span subtest of the WMS-III and estrogen-only users performed more poorly on this task than nonusers. APOE ε4 contributed unique variance to the Letter-Number Sequencing Subtest of the WMS-III. No significant HRT use by APOE interaction was found. Conclusion:In summary, HRT use was observed to have minimum effect overall on the performance of postmenopausal women on the WMS-III. The APOE ε4 allele was also demonstrated to have minimal influence on cognitive functioning, and it did not interact significantly with HRT to affect test performance.

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The effect of hormone replacement therapy on mood and everyday memory in younger mid-life women

Cited by 5 publications

References 36 publications

Pubertal stage and brain anatomy in girls

Pubertal stage and brain anatomy in girls

Perfil neuropsicológico en transexuales: efecto del tratamiento de reasignación de sexo

The relationship between hormone replacement therapy (HRT) and memory performance in women: influences of HRT type and APOE E4 allele status

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