The effect of honey upon calcium retentions in infants

Knott, Elizabeth M.; Shukers, Carroll F.; Schlutz, Frederic W.

doi:10.1016/s0022-3476(41)80046-8

Cited by 2 publications

(3 citation statements)

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“…This method allows direct quantification of mineral absorption in relation to the amount consumed, thus making it a more sensitive method than the metabolic balance technique used in previous studies (21,23,24). Furthermore, we investigated the calcium absorption effects of the nondigestible carbohydrates (e.g., raffinose) as individual components and as part of the food matrix (i.e., in the form of honey).…”

Section: Introductionmentioning

confidence: 99%

“…Fructose and glucose are the dominant carbohydrates in honey (30.9−44.3 and 22.9−40.8% by weight, respectively) , . One of the few studies investigating the effects of honey on calcium metabolism reported a higher calcium retention in infants fed honey-supplemented milk than control . Various studies based on animal models have also observed the calcium uptake-enhancing effects of raffinose , , , which is present in honey .…”

Section: Introductionmentioning

confidence: 99%

“…In the present study, we investigated the acute and chronic effects of honey and its carbohydrate constituents (specifically glucose, fructose, and raffinose) on calcium absorption in growing rats by applying an isotopic tracer method (based on femur uptake of 45 Ca). This method allows direct quantification of mineral absorption in relation to the amount consumed, thus making it a more sensitive method than the metabolic balance technique used in previous studies , , . Furthermore, we investigated the calcium absorption effects of the nondigestible carbohydrates (e.g., raffinose) as individual components and as part of the food matrix (i.e., in the form of honey).…”

Section: Introductionmentioning

confidence: 99%

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Acute and Chronic Effects of Honey and Its Carbohydrate Constituents on Calcium Absorption in Rats

Ariefdjohan

Martin

Lachcik

et al. 2008

J. Agric. Food Chem.

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The effects of honey and its carbohydrate constituents (glucose, fructose, and raffinose) on calcium absorption in rats were investigated in acute and chronic feeding studies. In the acute study, rats ( n = 120) were gavaged with an oral solution consisting of (a) 10 microCi (45)Ca, (b) 25 mg of calcium as calcium acetate, and (c) one of the following: 0 mg of honey (control), or 200, 500, or 800 mg of honey, a glucose-fructose mixture, 10.75 mg of raffinose, or 200 mg of raffinose. Another group received (45)Ca intraperitoneally. Femurs were collected 2 days later and analyzed for (45)Ca content. Rats given 500 and 800 mg of honey showed 25.5 and 33.6% increases in calcium absorption ( P<0.05), respectively, over the control group. Groups given the glucose-fructose mixture or 200 mg of raffinose had a significantly higher increase in calcium absorption than the control group (17.1 and 25.6%, respectively). In the chronic study, rats (n=96) were fed for 8 weeks with either 0% honey (control), 5% honey, 10% honey, or a glucose-fructose-raffinose (GFR) mixture. Femurs of GFR-fed rats had significantly lower calcium content, (45)Ca absorption, width, and BMD (at distal region) than control rats. Groups fed honey did not show the negative effects of GFR on bone, but had no advantage over the control group. No significant differences were observed in femur length, density, strength, or BMC among any treatment group compared to the control group. These results indicate that although a positive dose-response effect of honey and its carbohydrate constituents on calcium absorption was observed in the acute study, this effect disappeared upon long-term feeding in rats, implying adaptation had occurred.

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Section: Introductionmentioning

confidence: 99%