Acute and Chronic Effects of Honey and Its Carbohydrate Constituents on Calcium Absorption in Rats

Ariefdjohan, Merlin; Martin, Berdine R.; Lachcik, Pamela J.; Weaver, Connie M.

doi:10.1021/jf073357w

Cited by 31 publications

(27 citation statements)

References 37 publications

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“…Honey has been reported to increase calcium absorption to the bone as a result of acute feeding in rats [10]. However, in the present study, increase in serum total calcium has been observed only when exercise was combined with honey supplementation.…”

Section: Discussioncontrasting

confidence: 53%

“…One of the nutrients that has long tradition of use within various medical systems and prescribed for variety of uses from ancient time is honey. Ariefdjohan et al [10] reported that honey has the potential to increase calcium absorption after 2 days of acute feeding in rats. In addition, Hussain et al [11] reported that honey has similar effects with hormone replacement therapy on bone densitometry in postmenopausal women.…”

Section: Open Access Research Articlementioning

confidence: 99%

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Changes in Bone Metabolism and Antioxidant Status with Combined Exercise and Honey Supplementation in Young Female Rats

Tavafzadeh¹,

Ooi

Chen³

et al. 2015

JESO

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Open Access Research Articleactivity is through modification in bone turnover which occurs through two fundamentally different processes, i.e. modeling and remodeling with the activities of osteoblast and osteoclast cells in the mechanisms of bone formation and bone resorption [3]. A number of biochemical assays have been described for measuring serum and urinary concentration of markers of bone metabolism [4] that allow a good estimation of bone metabolic processes and have been established as useful parameters in assessing changes in bone turnover. To date, the mechanisms by which combined exercise and dietary intake lead to changes in bone metabolism are not fully understood.Nutritional supplementation is another main factor associated with bone health and development. Aoe et al. [5] reported that as compared to drugs that have a rapid effect, administration of nutrients related to bone metabolism is relatively safe and inexpensive. To date, the effects of different types of supplementation such as calcium, vitamin D, milk, soy and soy protein on bone mass, turnover and mineral density have been reported [6][7][8][9]. One of the nutrients that has long tradition of use within various medical systems and prescribed for variety of uses from ancient time is honey. Ariefdjohan et al. [10] reported that honey has the potential to increase calcium absorption after 2 days of acute feeding in rats. In addition, Hussain et al. [11] reported that honey has similar effects with hormone replacement therapy on bone densitometry in postmenopausal women. Therefore, it was hypothesized that honey may play a role in increasing bone health.Tualang honey is a wild, multi floral honey produced by Apis dorsata bees that form hives on the branches of giant trees named Tualang in the Malaysian rainforest, and it has been reported recently that ovariectomized rats that received Tualang honey showed greater improvements in trabecular bone structure than rats receiving calcium [12], implying the beneficial effects of Tualang honey supplementation on bone. Nevertheless to date, administration of Tualang honey in combination with exercise on bone health and antioxidant status in rats has not been investigated, thus the present study was proposed. AbstractPurpose: To investigate the effects of combined jumping exercise and honey supplementation on bone metabolism and antioxidant status in female rats.

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Section: Discussioncontrasting

confidence: 53%

Section: Open Access Research Articlementioning

confidence: 99%

Changes in Bone Metabolism and Antioxidant Status with Combined Exercise and Honey Supplementation in Young Female Rats

Tavafzadeh¹,

Ooi

Chen³

et al. 2015

JESO

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“…Uptake of 0.1 mM Ca 2ϩ , a low concentration that favors active transcellular uptake, in 160 mM fructose was greater than that in glucose (3). Total intestinal Ca 2ϩ absorption in vivo, determined acutely by femur uptake of 45 Ca 2ϩ , increased proportionally with increasing concentrations of honey, which is composed mostly of fructose (2).…”

Section: Discussionmentioning

confidence: 99%

“…Intestinal Ca 2ϩ absorption may depend, not only on dietary Ca 2ϩ and serum vitamin D concentrations, but also on dietary factors that may alter luminal Ca 2ϩ concentrations or interfere with Ca 2ϩ transporters. Dietary factors that have been shown to affect Ca 2ϩ bioavailability include plant fiber, fat, phosphorus, protein, and carbohydrate (1,2,9,35). Concerning potential interactions between intestinal carbohydrate and Ca 2ϩ absorption, most investigations have focused on the stimulating effect of the milk sugar lactose on the absorption of Ca 2ϩ (3,14,27,51,52), as these two nutrients are typically in the intestinal lumen at the same time.…”

mentioning

confidence: 99%

Acute interactions between intestinal sugar and calcium transport in vitro

Tharabenjasin

Douard

Patel

et al. 2014

American Journal of Physiology-Gastrointestinal and Liver Physi

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Fructose consumption by Americans has increased markedly, whereas Ca2+ intake has decreased below recommended levels. Because fructose metabolism decreases enterocyte ATP concentrations, we tested the hypothesis that luminal fructose acutely reduces active, diet-inducible Ca2+ transport in the small intestine. We confirmed that the decrease in ATP concentrations was indeed greater in fructose- compared with glucose-incubated mucosal homogenates from wild-type and was prevented in fructose-incubated homogenates from ketohexokinase (KHK)−/− mice. We then induced active Ca2+ transport by chronically feeding wild-type, fructose transporter glucose transporter 5 (GLUT5)−/−, as well as KHK−/− mice a low Ca2+ diet and measured transepithelial Ca2+ transport in everted duodenal sacs incubated in solutions containing glucose, fructose, or their nonmetabolizable analogs. The diet-induced increase in active Ca2+ transport was proportional to dramatic increases in expression of the Ca2+-selective channel transient receptor potential vanilloid family calcium channel 6 as well as of the Ca2+-binding protein 9k (CaBP9k) but not that of the voltage-dependent L-type channel Ca(v)1.3. Crypt-villus distribution of CaBP9k seems heterogeneous, but low Ca2+ diets induce expression in more cells. In contrast, KHK distribution is homogeneous, suggesting that fructose metabolism can occur in all enterocytes. Diet-induced Ca2+ transport was not enhanced by addition of the enterocyte fuel glutamine and was always greater in sacs of wild-type, GLUT5−/−, and KHK−/− mice incubated with fructose or nonmetabolizable sugars than those incubated with glucose. Thus duodenal Ca2+ transport is not affected by fructose and enterocyte ATP concentrations but instead may decrease with glucose metabolism, as Ca2+ transport remains high with 3- O-methylglucose that is also transported by sodium-glucose cotransporter 1 but cannot be metabolized.

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“…Therefore, we speculate that oligosaccharides in the MHCP expressed a prebiotic effect, which may have a beneficial effect on bone resorption in OVX mice. Furthermore, acute feeding of honey and its carbohydrate constituents (glucose, fructose, and raffinose) enhanced calcium absorption in rats [30] . Thus, carbohydrate constituents of the MHCP might have also increased calcium absorption in this study.…”

Section: Discussionmentioning

confidence: 99%

Effects of Manuka Honey Combined with α-Cyclodextrin on Bone Metabolism and Caecal Bacterial Contents in Ovariectomized Mice

Kruger¹

2015

IJFNS

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Honey has antimicrobial, antitumor, antioxidant, and anti-inflammatory effects. However, there have been few studies regarding the effects of manuka honey on bone metabolism and gut microflora. This study investigated the effects of manuka honey combined with α-cyclodextrin, Manuka Honey with Cyclopower TM (MHCP) on bone metabolism and caecal bacterial contents in ovariectomized (OVX) mice. Seven-week-old female Balb/c-strain mice were divided into four groups: sham-operated (sham) group, OVX group, and OVX mice that were fed a diet containing 5% or 10% (w/w) MHCP. After 9 weeks, the mice were sacrificed, and serum, uterus, caecum, and femur samples were obtained. Successful removal of the ovaries and induction of the osteoporotic process in OVX mice were demonstrated by a significant decrease in uterine weight and a significant increase in receptor activator of NF-κB ligand (RANKL) mRNA expression of the femur, compared to sham, respectively. Compared to the OVX group, MHCP reduced serum C-terminal telopeptide of type Ι collagen concentration as well as RANKL and nuclear factor of activated T-cells c1 (NFATc1) mRNA expression of the femur. Furthermore, MHCP increased caecal bifidobacteria and bacteroides contents. These results suggest that the MHCP expressed prebiotic effects, which might reduce bone resorption in OVX mice.

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Acute and Chronic Effects of Honey and Its Carbohydrate Constituents on Calcium Absorption in Rats

Cited by 31 publications

References 37 publications

Changes in Bone Metabolism and Antioxidant Status with Combined Exercise and Honey Supplementation in Young Female Rats

Changes in Bone Metabolism and Antioxidant Status with Combined Exercise and Honey Supplementation in Young Female Rats

Acute interactions between intestinal sugar and calcium transport in vitro

Effects of Manuka Honey Combined with α-Cyclodextrin on Bone Metabolism and Caecal Bacterial Contents in Ovariectomized Mice

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