The effect of histamine receptor antagonists on stress-induced catecholamine secretion: an adrenomedullary microdialysis study in the rat

Кузьмин, А И; Zaretsky, Dmitry V.; Kalenikova, E. I.; Zaretskaja, Maria V; Медведев, О. С.; Чазов, Е. И.

doi:10.1016/s0014-2999(99)00467-7

Cited by 6 publications

(11 citation statements)

References 18 publications

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“…In cold-stressed mice, basal catecholamine concentration in adrenal-venous blood was unexpectedly lower than that in control mice. This mismatches with previous data reporting a rise in catecholamine concentration in the adrenal vein in response to various stressors 33,36,43 . This also contrasts with the typical in vivo increase in catecholamine concentrations measured in plasma, in response to stressful situations 33,36,40,44 .…”

Section: Discussioncontrasting

confidence: 99%

“…In addition, the specie, collection technique and stimulation protocols varied from one study to the other, thus precluding trivial quantitative comparison. Basal and splanchnic nerve stimulation-evoked release of adrenal catecholamines has been directly measured in adrenal-venous blood only in a few cases, in the cat 30,31 , rat 15,23,32,33 and dog 34,35 but not in the mouse. Our in vivo data indicate a basal E:NE ratio close to 10:1 in the mouse.…”

Section: Discussionmentioning

confidence: 99%

“…This is consistent with previously reported ratios ranging from 2 to 7 (refs 15,31,33-35). It is noteworthy that it is the opposite when catecholamines are assayed in the plasma, in anaesthetised animals 30,33,35,36 , including mouse [37][38][39][40] . In response to electrical splanchnic nerve stimulation (0.1 and 4 Hz), adrenal catecholamine output significantly increased with stimulation frequency.…”

Section: Discussionmentioning

confidence: 99%

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Gap junction signalling is a stress-regulated component of adrenal neuroendocrine stimulus-secretion coupling in vivo

et al. 2013

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Section: Discussioncontrasting

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Gap junction signalling is a stress-regulated component of adrenal neuroendocrine stimulus-secretion coupling in vivo

et al. 2013

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“…Histamine H1 receptors stimulate adrenaline and noradrenaline secretions (Kuzmin et al 1999). Histamine H1 receptors stimulate glycogenolysis as inducing a rapid increase in inositol 1,4,5-trisphosphate levels and intracellular Ca 2+ concentration (Mine et al 1991;Cheng et al 2000).…”

Section: Introductionmentioning

confidence: 99%

“…However, histamine H2 receptors show widespread expression in the brain and spinal cord. Histamine H2 receptors stimulate noradrenaline release, but not adrenaline (Kuzmin et al 1999). Histamine H3 receptors located on various central and peripheral nerves negatively regulates the release of norepinephrine and acetylcholine in the central nervous system (CNS) (Molderings et al 1992;Tokita et al 2006).…”

Section: Introductionmentioning

confidence: 99%

Effect of histamine receptors agonists or antagonists administered intracerebroventricularly and intrathecally on the blood glucose level in immobilization stress model

Sharma

Sim

Park

et al. 2015

Animal Cells and Systems

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Effects of histamine receptors agonists or antagonists administered centrally (supraspinally or spinally) on immobilization stress-induced blood glucose levels were studied in Institute for Cancer Research mice. Mice were pretreated intracerebroventricularly (i.c.v.) or intrathecally (i.t.) with histamine (H1, H2, H3 and H4) receptor agonists or antagonists 10 min prior to immobilization stress (IMO) stimulation for 30 min. We found that the increased blood glucose level induced by IMO was attenuated by the i.c.v. pretreatment with α-methylhistamine (H3 agonist). However, H3 antagonist, H1, H2 and H4 receptor agonists and antagonists did not affect the blood glucose level. Also, i.t. pretreatment with α-methylhistamine or VUF 8430 attenuated the increased blood glucose level induced by IMO. In addition, cetirizine and carcinine enhanced the increased blood glucose level induced by IMO. However, the blood glucose level was not affected by H1 and H2 receptor agonists, H2 and H4 receptor antagonists. Corticosterone and insulin levels were also measured in α-methylhistamine (i.c.v or i.t) and with VUF 8430, carcinine and cetirizine (i.t.) treated group. We found that the corticosterone level was increased only by i.t treatment with α-methylhistamine, whereas the insulin level was attenuated by i.c.v or i.t. treatment with α-methylhistamine and i.t treatment with VUF 8430, carcinine and cetirizine. Our results suggest the active involvement of histamine receptor in blood glucose regulation in IMO.

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Reaction of rat brain capillaries to immobilization stress

Danielyan

2008

Neurosci Behav Physi

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The calcium adenosine triphosphate method of Chilingaryan was used to study the morphofunctional state of the capillary component of the microcirculatory bed of the brain in rats at different time points after experimental immobilization stress (fixation of the animal on its back for 2 h). Analysis of morphometric data showed that in comparison with intact animals, stress was immediately followed by constriction of capillaries by 17.2%, with compensatory dilation by 2.5% occurring at two days, and subsequent minor constriction by 5.6%. Morphometric measures in placid and aggressive animals showed that the behavioral stereotype of placid animals produced a more sparing physiological response to stress. It is suggested that the difference in capillary dysfunction is largely dependent on impairment of neuronal systems involved in regulating the microcirculation.

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The effect of histamine receptor antagonists on stress-induced catecholamine secretion: an adrenomedullary microdialysis study in the rat

Cited by 6 publications

References 18 publications

Gap junction signalling is a stress-regulated component of adrenal neuroendocrine stimulus-secretion coupling in vivo

Gap junction signalling is a stress-regulated component of adrenal neuroendocrine stimulus-secretion coupling in vivo

Effect of histamine receptors agonists or antagonists administered intracerebroventricularly and intrathecally on the blood glucose level in immobilization stress model

Reaction of rat brain capillaries to immobilization stress

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