Gap junction signalling is a stress-regulated component of adrenal neuroendocrine stimulus-secretion coupling in vivo

Desarménien, Michel G.; Jourdan, Camille; Toutain, Bertrand; Vessières, Emilie; Hormuzdi, Sheriar G.; Guérineau, Nathalie C.

doi:10.1038/ncomms3938

Cited by 37 publications

(57 citation statements)

References 65 publications

(110 reference statements)

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“…As shown in Table 1, Cx43 emerges as the major, if not exclusive, gap junction protein expressed in the adrenal cortex. With the exception of the human adrenal cortex, which expresses Cx26, Cx32 and Cx50 in addition to Cx43 [7], no signal was detected for Cx26, Cx31, Cx32, Cx36, Cx37, Cx40 and Cx46 [8][9][10][11][12] in mammals. Of note, we recently identified Cx37, Cx40 and Cx45 transcripts in the mouse cortex (unpublished results).…”

Section: Connexin Expression and Distributionmentioning

confidence: 99%

“…As hypothesized [21], gap junctional communication in the adrenal cortex plays a pivotal role in a number of interactive cell [8,9,13,15] Mouse ? [9,12,14,27] Guinea pig ? [9] Cow ?…”

Section: Connexin Intercellular Channelsmentioning

confidence: 99%

“…The presence of connexins between chromaffin cells, mainly Cx36 and Cx43, in rodents [12,15,34,35] strongly suggests the involvement of gap junction membrane channels in hormone secretion [36]. In a paper published in the early 2000s, Martin and colleagues [15] described for the first time the presence of functional gap junctional communication between rat chromaffin cells in acute adrenal slices and its role as an additional component of Fig.…”

Section: Connexin Intercellular Channelsmentioning

confidence: 99%

“…Because robust coupling supports the propagation of action potentials, and ensuing rises in intracellular calcium concentration, between cells, it appears as a key determinant in the increased catecholamine secretion observed in response to stress. Data collected from experiments performed in rat [15,34], mouse [12] and bovine [51] adrenal medullary tissue stimulus-secretion coupling. Due to electrical coupling, a single stimulated cell can propagate its stimulus, such as electrical or nicotine/acetylcholine-evoked depolarization, to its neighbors, resulting in synchronous multicellular cytosolic rises in intracellular calcium concentrations and catecholamine release (Fig.…”

Section: Connexin Intercellular Channelsmentioning

confidence: 99%

“…1). The occurrence of gap junctional coupling in the adrenal medulla is highly plastic and depends on various factors (Table 4) [37], including age [38,39], species [30,40], gender [15,34,35], physiological (i.e., stressed/unstressed) state [12,34,41] and splanchnic innervation competence [38,39]. Supporting the role of gap junctions in adrenal medulla endocrine function are data reporting upregulated gap junctional communication between chromaffin cells in response to pharmacological or surgical impairment of splanchnic innervation [38], or in the neonatal adrenal medulla in which the innervation is not yet fully competent [39].…”

Section: Connexin Intercellular Channelsmentioning

confidence: 99%

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Roles of connexins and pannexins in (neuro)endocrine physiology

Hodson

Legros

Desarménien

et al. 2015

Cell. Mol. Life Sci.

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To ensure appropriate secretion in response to demand, (neuro)endocrine tissues liberate massive quantities of hormones, which act to coordinate and synchronize biological signals in distant secretory and nonsecretory cell populations. Intercellular communication plays a central role in this control. With regard to molecular identity, junctional cell-cell communication is supported by connexin-based gap junctions. In addition, connexin hemichannels, the structural precursors of gap junctions, as well as pannexin channels have recently emerged as possible modulators of the secretory process. This review focuses on the expression of connexins and pannexins in various (neuro)endocrine tissues, including the adrenal cortex and medulla, the anterior pituitary, the endocrine hypothalamus and the pineal, thyroid and parathyroid glands. Upon a physiological or pathological stimulus, junctional intercellular coupling can be acutely modulated or persistently remodeled, thus offering multiple regulatory possibilities. The functional roles of gap junction-mediated intercellular communication in endocrine physiology as well as the involvement of connexin/pannexin-related hemichannels are also discussed.

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Section: Connexin Expression and Distributionmentioning

confidence: 99%

“…As hypothesized [21], gap junctional communication in the adrenal cortex plays a pivotal role in a number of interactive cell [8,9,13,15] Mouse ? [9,12,14,27] Guinea pig ? [9] Cow ?…”

Section: Connexin Intercellular Channelsmentioning

confidence: 99%

Section: Connexin Intercellular Channelsmentioning

confidence: 99%

Section: Connexin Intercellular Channelsmentioning

confidence: 99%

Section: Connexin Intercellular Channelsmentioning

confidence: 99%

See 3 more Smart Citations

Roles of connexins and pannexins in (neuro)endocrine physiology

Hodson

Legros

Desarménien

et al. 2015

Cell. Mol. Life Sci.

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Chromaffin Cells of the Adrenal Medulla: Physiology, Pharmacology, and Disease

Carbone

Borges

Eiden

et al. 2019

Comprehensive Physiology

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Cell Networks in Endocrine/Neuroendocrine Gland Function

Guérineau

Campos

Tissier

et al. 2022

Comprehensive Physiology

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Reproduction, growth, stress and metabolism are determined by endocrine/neuroendocrine systems that regulate circulating hormone concentrations. All these systems generate rhythms and changes in hormone pulsatility observed in a variety of pathophysiological states. Thus, the output of endocrine/neuroendocrine systems must be regulated within a narrow window of effective hormone concentrations but must also maintain a capacity for plasticity to respond to changing physiological demands. Remarkably most endocrinologists still have a 'textbook' view of endocrine gland organization which has emanated from 20 th century histological studies on thin 2D tissue sections. However, 21 st century technological advances, including indepth 3D imaging of specific cell types have vastly changed our knowledge. We now know that various levels of multi-cellular organization can be found across different glands, that organizational motifs can vary between species and can be modified to enhance or decrease hormonal release. This review focuses on how the organization of cells regulates hormone output using three endocrine/neuroendocrine glands that present different levels of organization and complexity: the adrenal medulla, with a single neuroendocrine cell type; the anterior pituitary, with multiple intermingled cell types; and the pancreas with multiple intermingled cell types organized into distinct functional units. We give an overview of recent methodologies that allow the study of the different components within endocrine systems, and particularly their temporal and spatial relationships. We believe the emerging findings about network organization, and its impact on hormone secretion, are crucial to understanding how homeostatic regulation of endocrine axes is carried out within endocrine organs themselves.

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Gap junction signalling is a stress-regulated component of adrenal neuroendocrine stimulus-secretion coupling in vivo

Cited by 37 publications

References 65 publications

Roles of connexins and pannexins in (neuro)endocrine physiology

Roles of connexins and pannexins in (neuro)endocrine physiology

Chromaffin Cells of the Adrenal Medulla: Physiology, Pharmacology, and Disease

Cell Networks in Endocrine/Neuroendocrine Gland Function

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