The effect of hepatitis B virus infected embryos on pregnancy outcome

Ye, Feng; Liu, Yi; Jin, Yan; Shi, Juanzi; Yang, Xiaojiao; Liu, Xiaojing; Zhang, Xi; Su, Lin; Kong, Ying; Zhang, Linshu

doi:10.1016/j.ejogrb.2013.10.002

Cited by 32 publications

(30 citation statements)

References 14 publications

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“…Furthermore, the results indicated that neonatal infant HBV vertical transmission and the presence of HBsAg in the father exerted no statistically significant effects on the aforementioned indicators (Table IV). Previous studies have found that the rate of sperm chromosome aberrations in fathers infected with HBV was significantly higher compared with healthy controls, while the presence of HBV can also increase the rates of infertility, miscarriage, stillbirth, perinatal child mortality and the risk of fetal malformations (16,(20)(21)(22); however, the results of the present study were different. The results demonstrated that the use of antiviral nucleoside analogs prior to pregnancy was safe in fathers.…”

Section: Discussioncontrasting

confidence: 90%

Efficacy and safety of nucleoside analogs on blocking father-to-infant vertical transmission of hepatitis B virus

Cao

Zhao

Liu

et al. 2015

Experimental and Therapeutic Medicine

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Section: Discussioncontrasting

confidence: 90%

Efficacy and safety of nucleoside analogs on blocking father-to-infant vertical transmission of hepatitis B virus

Cao

Zhao

Liu

et al. 2015

Experimental and Therapeutic Medicine

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“…The vertical transmission of HBV from the HBsAg-positive fathers to the infants also had no significant effect on the aforementioned newborn indicators (Table IV). Previous studies have shown that an HBV-infected male, whose sperm chromosome aberration rate is significantly increased compared with healthy controls, may experience an increased risk of infertility, abortion, stillbirth, perinatal mortality and fetal malformations (18)(19)(20)(21). The present results are not consistent with these findings.…”

Section: P-value T-value --------------------------------------------contrasting

confidence: 99%

Effect of hepatitis B vaccination in hepatitis B surface antibody-negative pregnant mothers on the vertical transmission of hepatitis B virus from father to infant

Cao

Wang

et al. 2015

Experimental and Therapeutic Medicine

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Abstract. The aim of the present study was to investigate the effects of vaccination with the hepatitis B vaccine (HBVac) in HB surface antibody (HBsAb)-negative pregnant mothers on the vertical transmission of HB virus (HBV) from father to infant. All the fathers tested positive for the serum HBV DNA and HB surface antigen (HBsAg) markers. The pregnant females were divided into an observation group or a control group depending on whether their serum was HBsAb-negative or positive. A total of 93 healthy individuals without HBV infection were included in a blank group, while 96 females who were serum HBV marker-negative or HB core antibody (HBcAb)-positive/(HBsAb)-negative were included in the observation group. The control group comprised 89 females who all tested positive for serum HBsAb, HB envelope antibodies and HBcAb. In the observation group, the positive rate of HBV DNA in the newborns was 7.29% (7/96), the positive rate of HBsAg was 3.13% (3/96) and the positive rate of HBsAb was 81.3% (78/96). In the control group, the positive rates of HBV DNA, HBsAg and HBsAb in the newborns were 4.49% (4/89), 2.25% (2/89) and 89.9% (80/89), respectively. No statistically significant differences were observed between the two groups. Therefore, the results of the present study indicate that HBVac treatment for HBsAb-negative pregnant females may have a positive role in blocking the vertical transmission of HBV from father to infant, as long as the vaccination is able to induce the production of a sufficient quantity of HBsAb. The HBVac exhibited no difference compared with pre-pregnancy HBsAb in blocking the vertical transmission of HBV from father to infant.

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“…This result suggests that a risk of vertical transmission of HBV [with the father being HBsAg (+)] had no significant effect on the fetus in the above aspects (see the results in Table 4). Our conclusion contradicts that of many other researchers in which chromosome aberration in patients with HBV infection was suggested to be a significant risk factor for infertility, spontaneous abortion, fetal death, fetus malformation, and perinatal infant mortality (Livezey et al, 2002;Huang et al, 2003;Vicari et al, 2006;Ye et al, 2014).…”

Section: General Health Status Of Newbornscontrasting

confidence: 99%

Efficacy of combined hepatitis B immunoglobulin and hepatitis B vaccine in blocking father-infant transmission of hepatitis B viral infection

et al. 2015

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ABSTRACT. The aim of this study was to examine the efficacy of combined immunization of hepatitis B immunoglobulin (HBIG) and hepatitis B vaccine (HBVac) in blocking father-infant transmission of hepatitis B virus (HBV). Newborns positive at birth for blood HBV surface antigen (HBsAg) and/or HBV DNA were selected and immunized with HBIG combination HBVac. At 7 months, HBV markers and HBV DNA of each neonate were measured using electrochemiluminescence with the Cobas-e-411 Automatic Electrochemiluminescence Immunoassay Analyzer and fluorescence quantitative polymerase chain reaction. Among all 7-month-old subjects, the negative conversion rates of HBV DNA and HBsAg were 48/61 (78.7%) and 19/41 (46.3%), respectively. Therefore, this study demonstrated that prompt combination L.-H. Cao et al. 4652©FUNPEC-RP www.funpecrp.com.br Genetics and Molecular Research 14 (2): 4651-4657 (2015) injection of HBIG and HBVac can protect some of the HBV DNA-and/ or HBsAg-positive newborns from HBV.

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The effect of hepatitis B virus infected embryos on pregnancy outcome

Cited by 32 publications

References 14 publications

Efficacy and safety of nucleoside analogs on blocking father-to-infant vertical transmission of hepatitis B virus

Efficacy and safety of nucleoside analogs on blocking father-to-infant vertical transmission of hepatitis B virus

Effect of hepatitis B vaccination in hepatitis B surface antibody-negative pregnant mothers on the vertical transmission of hepatitis B virus from father to infant

Efficacy of combined hepatitis B immunoglobulin and hepatitis B vaccine in blocking father-infant transmission of hepatitis B viral infection

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