Efficacy and safety of nucleoside analogs on blocking father-to-infant vertical transmission of hepatitis B virus

Cao, Lihua; Zhao, P.-L.; Liu, Zhimin; Sun, Shao‐Chun; Xu, Dongbo; Zhang, Jidong; Shao, Mei‐Hua

doi:10.3892/etm.2015.2379

Cited by 3 publications

(2 citation statements)

References 18 publications

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“…Nucleoside analogs are widely used for the prevention and treatment of several viral infections, including human immunodeficiency virus, hepatitis B virus, and herpes infections ( Albrecht et al, 1970 ; Burchenal et al, 1975 ; Aguirrebengoa et al, 1996 ; Adams et al, 1997 ; Bavoux et al, 2000 ; Quan and Peters, 2004 ; Anderson, 2008 ; Angusti et al, 2008 ; Ambrose et al, 2009 ; Billioud et al, 2011 ; Agarwal et al, 2015 ; Cao et al, 2015 ; Ehteshami et al, 2017 ). Due to their hydrophilic nature, nucleoside analogs depend on a carrier-mediated transport process to permeate through host cell membranes before exhibiting their antiviral activities ( Yao et al, 1996 ; Damaraju et al, 2011 ; Moss et al, 2012 ).…”

Section: Introductionmentioning

confidence: 99%

Identification of Structural and Molecular Features Involved in the Transport of 3′-Deoxy-Nucleoside Analogs by Human Equilibrative Nucleoside Transporter 3

2018

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Combination antiretroviral drug treatments depend on 3′-deoxy-nucleoside analogs such as 3′-azido-3′-deoxythymidine (AZT) and 2′3′-dideoxyinosine (DDI). Despite being effective in inhibiting human immunodeficiency virus replication, these drugs produce a range of toxicities, including myopathy, pancreatitis, neuropathy, and lactic acidosis, that are generally considered as sequelae to mitochondrial damage. Although cell surface–localized nucleoside transporters, such as human equilibrative nucleoside transporter 2 (hENT2) and human concentrative nucleoside transporter 1 (hCNT1), are known to increase the carrier-mediated uptake of 3′-deoxy-nucleoside analogs into cells, another ubiquitously expressed intracellular nucleoside transporter (namely, hENT3) has been implicated in the mitochondrial transport of 3′-deoxy-nucleoside analogs. Using site-directed mutagenesis, generation of chimeric hENTs, and 3H-permeant flux measurements in mutant/chimeric RNA–injected Xenopus oocytes, here we identified the molecular determinants of hENT3 that dictate membrane translocation of 3′-deoxy-nucleoside analogs. Our findings demonstrated that whereas hENT1 had no significant transport activity toward 3′-deoxy-nucleoside analogs, hENT3 was capable of transporting 3′-deoxy-nucleoside analogs similar to hENT2. Transport analyses of hENT3-hENT1 chimeric constructs demonstrated that the N-terminal half of hENT3 is primarily responsible for the hENT3–3′-deoxy-nucleoside analog interaction. In addition, mutagenic studies identified that 225D and 231L in the N-terminal half of hENT3 partially contribute to the ability of hENT3 to transport AZT and DDI. The identification of the transporter segment and amino acid residues that are important in hENT3 transport of 3′-deoxy-nucleoside analogs may present a possible mechanism for overcoming the adverse toxicities associated with 3′-deoxy-nucleoside analog treatment and may guide rational development of novel nucleoside analogs.

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Section: Introductionmentioning

confidence: 99%

Identification of Structural and Molecular Features Involved in the Transport of 3′-Deoxy-Nucleoside Analogs by Human Equilibrative Nucleoside Transporter 3

2018

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“…However, other studies have shown similar results; it was safe for fathers with CHB during exposure to ETV pregnancy and the baby had no abnormalities or deformities (24)(25)(26)(27); there was no need to terminate the pregnancy.…”

Section: Discussionmentioning

confidence: 62%

Safety of entecavir antiviral therapyduring an accidental pregnancy in patients with chronic hepatitis B

Cao,

Li,

Dong

et al. 2023

Biomed Rep

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The present study aimed to investigate the effects of accidental pregnancy CHB patients' reproductive age on their offspring during entecavir (ETV) antiviral therapy. A total of 112 couples were retrospectively enrolled, and they were divided into an observational and control group. A total of 53 couples who had accidental pregnancies while receiving long-term ETV antiviral medication were recruited for the observational group. The control group consisted of 59 couples who became pregnant accidentally while receiving long-term tenofovir disoproxil fumarate (TDF) antiviral treatment. All mothers persisted in their pregnancies in the observational group, and ETV was promptly replaced with TDF. Every mother remained pregnant and continued to use TDF in the control group. The maternal and baby safety profiles, including the prevalence of congenital disabilities, were comparable across the observational and control groups at delivery. In addition, no unusual indications or symptoms of the newborns were noted during the follow-up intervals of 28, 48, and 96 weeks postpartum. Initiating ETV or TDF in early and middle pregnancy seems safe for mothers and infants. Important data from the present study support using ETV in early-mid gestational accidental pregnancies and the prompt substitution of TDF antiviral medication for ETV.

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Prevention strategy for father-to-child transmission of hepatitis B virus: a systematic review and meta-analysis

Chen

Zha

Qin

2017

The Journal of Maternal-Fetal & Neonatal Medicine

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Efficacy and safety of nucleoside analogs on blocking father-to-infant vertical transmission of hepatitis B virus

Cited by 3 publications

References 18 publications

Identification of Structural and Molecular Features Involved in the Transport of 3′-Deoxy-Nucleoside Analogs by Human Equilibrative Nucleoside Transporter 3

Identification of Structural and Molecular Features Involved in the Transport of 3′-Deoxy-Nucleoside Analogs by Human Equilibrative Nucleoside Transporter 3

Safety of entecavir antiviral therapyduring an accidental pregnancy in patients with chronic hepatitis B

Prevention strategy for father-to-child transmission of hepatitis B virus: a systematic review and meta-analysis

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