The effect of henna and linseed herbal ointment blend on wound healing in rats with second-degree burns

Naseri, Saeed; Golpich, Mojtaba; Roshancheshm, Tohid; Joobeni, Mohammad Ghadimi; Khodayari, Moein; Noori, Salar; Zahed, Seyyed Asghar; Razzaghi, Sara; Shirzad, Mohammad; Salavat, Farhad Saber; Dakhilpour, Seyede Simin

doi:10.1016/j.burns.2020.12.009

Cited by 6 publications

(4 citation statements)

References 39 publications

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“…After applying linseed oil to second-degree burns in rats, a higher wound closure rate was observed, and the performed biopsy showed better tissue regenerative properties and higher angiogenesis than the control [ 80 ]. In another study, also on the model of second-degree burns in rats, it was confirmed that after 21 days of linseed oil application, the severity of the inflammatory process decreased, and collagen synthesis, re-epithelialization, and angiogenesis increased [ 81 ]. In a burn model in rabbits, after 12 days of treatment with linseed oil, the degree of wound closure was significantly higher than in the control group; moreover, complete wound closure was 9 days earlier than in the control group.…”

Section: Phytotherapy In Skin Diseasesmentioning

confidence: 94%

Current Knowledge on Interactions of Plant Materials Traditionally Used in Skin Diseases in Poland and Ukraine with Human Skin Microbiota

Melnyk

Vlasova

Skowrońska

et al. 2022

IJMS

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Skin disorders of different etiology, such as dermatitis, atopic dermatitis, eczema, psoriasis, wounds, burns, and others, are widely spread in the population. In severe cases, they require the topical application of drugs, such as antibiotics, steroids, and calcineurin inhibitors. With milder symptoms, which do not require acute pharmacological interventions, medications, dietary supplements, and cosmetic products of plant material origin are gaining greater popularity among professionals and patients. They are applied in various pharmaceutical forms, such as raw infusions, tinctures, creams, and ointments. Although plant-based formulations have been used by humankind since ancient times, it is often unclear what the mechanisms of the observed beneficial effects are. Recent advances in the contribution of the skin microbiota in maintaining skin homeostasis can shed new light on understanding the activity of topically applied plant-based products. Although the influence of various plants on skin-related ailments are well documented in vivo and in vitro, little is known about the interaction with the network of the skin microbial ecosystem. The review aims to summarize the hitherto scientific data on plant-based topical preparations used in Poland and Ukraine and indicate future directions of the studies respecting recent developments in understanding the etiology of skin diseases. The current knowledge on investigations of interactions of plant materials/extracts with skin microbiome was reviewed for the first time.

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Section: Phytotherapy In Skin Diseasesmentioning

confidence: 94%

Current Knowledge on Interactions of Plant Materials Traditionally Used in Skin Diseases in Poland and Ukraine with Human Skin Microbiota

Melnyk

Vlasova

Skowrońska

et al. 2022

IJMS

View full text Add to dashboard Cite

show abstract

“…Generally, the studies have proven the efficacy of using linen or flax oil to promote wound healing [ 95 , 96 , 97 , 98 , 99 , 100 , 101 ]. There exist some conflicting studies that have not shown much beneficial effect [ 102 , 103 ] and a concern of specific preparations of linen that may induce dermal irritation [ 99 ]. However, the majority of evidence would support the continued use of linen in promoting wound healing.…”

Section: Wound Healingmentioning

confidence: 99%

Physiological and Pathological Considerations for the Use of Flaxseed as a Therapeutic Dietary Strategy

Hirst,

Dibrov,

Hirst

et al. 2023

Rev. Cardiovasc. Med.

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The inclusion of flaxseed in the diet may have a great number of potential benefits for the well-being of both healthy individuals and those challenged by disease conditions as well. With an increase in the number and quality of studies focused on the physiological and pathophysiological effects of dietary flaxseed, our knowledge concerning the rationale for the inclusion of flaxseed in our diet has become more convincing and stronger. The purpose of this review is threefold. First, the review will comprehensively document the evidence supporting the value of dietary flaxseed to improve bodily health in both normal and disease conditions. Second, this review will identify the mechanisms of action responsible for these effects. Finally, this article will review practical aspects relevant to the inclusion of flaxseed in the diet. Briefly, supplementing the diet with flaxseed has beneficial effects on the treatment and/or prevention of different kinds of cardiovascular disease (hypertension, ischemic heart disease, myocardial infarcts, atherosclerosis), non-alcoholic fatty liver disease, breast cancer, bone strength, menopause, diabetes, and wound healing. Although some controversy exists on the component within flaxseed that provides these beneficial actions, it is likely that the rich content of the omega-3 fatty acid, alpha linolenic acid, is primarily responsible for the majority of these biological effects. It is concluded that the constantly expanding evidence in support of the inclusion of flaxseed in our daily diet to provide significant health benefits strongly encourages the initiation of additional work on dietary flaxseed in order to both confirm past findings as well as to further advance our knowledge regarding the important biological actions of dietary flaxseed.

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“…Furthermore, wounds caused by burns with reduced skin resistance as a physical barrier cause pain and enhanced sensitivity. 7 In order to alleviate these problems, dressings in the form of films, hydrogels, composites and sprays are used to protect the injury site and improve wound healing processes. 8 Traditional wound dressings such as cotton, bandages, wool, and gauze have limitations, including the low absorption of exudates, penetration by pathogens and required removal of the materials post-healing, resulting in disruption of the healed skin tissue.…”

Section: Introductionmentioning

confidence: 99%

“…In addition, wound healing processes can be impaired by certain pathological conditions, including diabetes mellitus, which is projected to affect around 439 million people worldwide by 2030. Furthermore, wounds caused by burns with reduced skin resistance as a physical barrier cause pain and enhanced sensitivity 7 …”

Section: Introductionmentioning

confidence: 99%

Alginate/polyvinyl alcohol films for wound healing: Advantages and challenges

et al. 2022

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The skin is the largest organ in the human body and its physical integrity must be maintained for body homeostasis and to prevent the entry of pathogenic microorganisms. Sodium alginate (SA) and polyvinyl alcohol (PVA) are two polymers widely used in films for wound dressing applications. Furthermore, blends between SA and PVA improve physical, mechanical and biological properties of the final wound healing material when compared to the individual polymers. Different drugs have been incorporated into SA/PVA-based films to improve wound healing activity. It is noteworthy that SA/PVA films can be crosslinked with Ca 2+ or other agents, which improves physicochemical and biological properties. Thus, SA/PVA associations are promising for the biomedical field, as a potential alternative for wound treatment. This review focuses on the main techniques for obtaining SA/PVA films, their physical-chemical characterization, drug incorporation, and the advantages and challenges of these films for wound healing.

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The effect of henna and linseed herbal ointment blend on wound healing in rats with second-degree burns

Cited by 6 publications

References 39 publications

Current Knowledge on Interactions of Plant Materials Traditionally Used in Skin Diseases in Poland and Ukraine with Human Skin Microbiota

Current Knowledge on Interactions of Plant Materials Traditionally Used in Skin Diseases in Poland and Ukraine with Human Skin Microbiota

Physiological and Pathological Considerations for the Use of Flaxseed as a Therapeutic Dietary Strategy

Alginate/polyvinyl alcohol films for wound healing: Advantages and challenges

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