The effect of hemodialysis on individual retinal layer thickness

Maharshak, Idit; Hecht, Idan; Mankuta, Lihi; Achiron, Asaf; Spierer, Oriel; Burgansky, Zvia; Bar, Asaf; Grossbard, Aliza; Katkov, Anna; Cernes, Relu; Feldman, Leonid

doi:10.1007/s10792-020-01677-x

Cited by 2 publications

(8 citation statements)

References 23 publications

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“…The impact of systemic changes that occur during HD, which vary in different studies, may lead to the final difference in the obtained results regarding both RT and pRNFL thickness [12][13][14][15][16][17]. In our study, there was a statistically significant correlation between the change in body weight and the change in pRNFL thickness, as well as between the change in DBP and the change in RT.…”

Section: Discussionmentioning

confidence: 48%

“…However, a significant number of studies indicate no effect of an HD session on RT or even a decrease in RT after HD [6,12,13,[16][17][18][19][20][21][22][23]25,26]. The differences may be due to small groups of subjects, methodological differences between studies, differences in the OCT types used, and differences in the groups of subjects themselves, including age, gender, axial length, refraction, or ethnic origin, all of which influence the retinal, GCL and pRNFL thickness [6,7,[12][13][14][15][16][17][18][19][20][21][22][23][24][25][26]30]. The aetiology of CKD in the studied patients subjected to HD may be of particular importance with respect to differences in the obtained results.…”

Section: Discussionmentioning

confidence: 99%

“…The impact of DM and the associated microangiopathy may affect not only the baseline RT but also its response to HD. The available literature includes studies assessing RT in the NDM group only [7,15,18,25], mixed groups of DM and NDM patients [6,[12][13][14]16,17,19,[21][22][23]26] or DM patients who were also assessed with respect to the degree of DR or the presence of macular oedema [20,24,31].…”

Section: Discussionmentioning

confidence: 99%

“…The way that the retina reacts to a single HD session is not obvious, and the studies give contradictory results, from RT decrease through no changes to RT thickness increase [6,7,[12][13][14][15][16][17][18][19][20][21][22][23][24][25][26]. The changes regarding pRNFL also differ in respective studies [7,13,19,24].…”

Section: Introductionmentioning

confidence: 99%

“…The changes regarding pRNFL also differ in respective studies [7,13,19,24]. Only two studies assessed the reaction of selected retinal layers to HD sessions [12,13]. Changes in systemic parameters resulting from HD session and their impact on RT and pRNFL thickness changes were described only in several studies [13][14][15][16][17].…”

Section: Introductionmentioning

confidence: 99%

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The Impact of a Single Haemodialysis Session on the Retinal Thickness and Optic Nerve Morphology

Roskal-Wałek,

Gołębiewska,

Mackiewicz

et al. 2024

Diagnostics

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Background: The aim of the study was to assess the influence of a single haemodialysis (HD) session on the retinal and optic nerve morphology in end-stage kidney disease (ESKD) patients. Methods: It is a prospective study including only the right eye of 35 chronic kidney disease (CKD) patients subjected to HD. Each patient underwent a full eye examination 30 min before HD (8 a.m.) and 15 min after HD. Optical coherence tomography (OCT) was used to assess the peripapillary retinal nerve fibre layer (pRNFL) thickness, macular nerve fibre layer (mRNFL) thickness, ganglion cell layer with inner plexiform layer thickness (GCL+), GCL++ (mRNFL and GCL+) thickness, total retinal thickness (RT) and total macular volume (TMV). The correlation was tested between such systemic parameters changes as systolic blood pressure (SBP), diastolic blood pressure (DBP), mean arterial pressure (MAP), body weight, plasma osmolarity and ocular perfusion pressure (OPP) and ultrafiltration volume with total RT and pRNFL thickness changes during HD. Results: In the results of a single HD session, we could observe a statistically significant increase in the total RT thickness (pre-HD 270.4 ± 19.94 μm, post-HD 272.14 ± 20.11 μm; p = 0.0014), TMV (pre-HD 7.48 ± 0.53 mm3, post-HD 7.52 ± 0.55 mm3; p = 0.0006), total pRNFL thickness (pre-HD 97.46 ± 15.71 μm, post-HD 100.23 ± 14.7 μm; p = 0.0039), total GCL+ thickness (pre-HD 70.11 ± 9.24 μm, post-HD 70.6 ± 9.7 μm; p = 0.0044), and GCL++ thickness (pre-HD 97.46 ± 12.56 μm, post-HD 97.9 ± 12.94 μm; p = 0.0081). We observed a significant correlation between the change in total RT and DBP change, as well as between body weight change and the change in total pRNFL thickness. There was also a correlation between total pRNFL thickness change and the presence of diabetes mellitus. Conclusion: Even a single HD session affects the retinal and pRNFL thickness, which should be taken into account when interpreting the OCT results in patients subjected to HD. The impact of changes after a single HD session on selected parameters requires further assessment in subsequent studies, including long-term observation.

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Section: Discussionmentioning

confidence: 48%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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The Impact of a Single Haemodialysis Session on the Retinal Thickness and Optic Nerve Morphology

Roskal-Wałek,

Gołębiewska,

Mackiewicz

et al. 2024

Diagnostics

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Evaluation of Ocular Perfusion in Patients with End-Stage Renal Disease Receiving Hemodialysis Using Optical Coherence Tomography Angiography

Lahme¹,

Storp²,

Marchiori

et al. 2023

JCM

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Hemodialysis (HD) is known to affect ocular blood flow. This case-control study aims to evaluate macular and peripapillary vasculature in patients with end-stage renal disease (ESRD) receiving HD in comparison to matched controls. A total of 24 eyes of 24 ESRD patients receiving HD and 24 eyes of 24 healthy, age- and gender-matched control subjects were prospectively included in this study. Optical coherence tomography angiography was used to image the superficial (SCP), deep (DCP), and choriocapillary (CC) macular vascular plexus, as well as the radial peripapillary capillaries (RPC) of the optic disc. In addition, retinal thickness (RT) and retinal volume (RV) were compared between both groups. Flow density (FD) values of each retinal layer and data of parameters related to the foveal avascular zone (FAZ), as well as RT and RV, were analyzed using Mann–Whitney U tests. There was no significant difference in FAZ parameters between the two groups. Whole en face FD of the SCP and CC was noticeably reduced in the HD group in comparison to the control group. FD was negatively correlated with the duration of HD treatment. RT and RV were significantly smaller in the study group than in controls. Retinal microcirculation appears altered in patients with ESRD undergoing HD. Concurrently, the DCP appears more resilient towards hemodynamic changes in comparison to the other microvascular retinal layers. OCTA is a useful, non-invasive tool to investigate retinal microcirculation in ESRD patients.

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The effect of hemodialysis on individual retinal layer thickness

Cited by 2 publications

References 23 publications

The Impact of a Single Haemodialysis Session on the Retinal Thickness and Optic Nerve Morphology

The Impact of a Single Haemodialysis Session on the Retinal Thickness and Optic Nerve Morphology

Evaluation of Ocular Perfusion in Patients with End-Stage Renal Disease Receiving Hemodialysis Using Optical Coherence Tomography Angiography

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