The effect of haemostatic agents on early healing of the extraction socket

Guo, Xiaodong; Hu, Haikun; Liu, Yindong; Bao, Chongyun

doi:10.1111/jcpe.13122

Cited by 10 publications

(7 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The SEM results of the present study demonstrated that at the end of the second week after extraction, the socket of control group revealed smooth bone surface with fine irregularities, the interconnecting bone trabeculae appeared surrounding numerous variable sized osteocyte spaces and loosely attached collagen bundles. This in agreement with Guo et al 2019 who found that SEM results of healing of extraction socket at 14 day showed regular, thin, bony spicule at the healing socket with wide bone marrow spaces (32). While in contrast Capetillo, et al 2017 showed that SEM after 2 weeks of extraction, revealed that the central part of the healing socket was empty representing only granulation tissue formation (33).…”

Section: Discussionsupporting

confidence: 76%

Scannining Electron Microscopic Evaluation of the Effect of Boron and Fish Oil on Healing of Extraction Sockets in Rats

AbdElfatah

Samad

Koura

et al. 2020

Alexandria Dental Journal

View full text Add to dashboard Cite

INTRODUCTION: Great incidence of complications have been reported tooth extraction. Many materials and drugs were used previously to cover extraction socket in an attempt to enhance healing or prevent post-operative complications. Several studies suggested that Boron and fish oil affect many of the biological processes during bone healing by influencing cell membrane function. Thus, they affect cellular responses to cytokines and hormones, including those involved in bone growth and turnover in rats. OBJECTIVE: of the study: To evaluate the effect of boron and fish oil on alveolar bone healing after tooth extraction in rats using Scanning Electron Microscope, Energy Dispersive x-ray analysis [EDXA] and serum alkaline phosphatase analysis. MATERIALS AND METHODS: forty-five adult male albino rats (120-150 gm in weight) were used in this study. Extraction of the lower 1 st molar was performed in all animals then they were randomly divided into 3 equal groups; Group I (control) including 15 rats fed on normal diet, Group II (boron) including 15 rats receiving normal diet and boron supplementation (3 mg/kg boron diluted in 3.5 ± 4 ml distilled water) daily, Group III (fish oil) including 15 rats receiving normal diet and fish oil supplementation (65 mg/kg fish oil) daily. The animals were sacrificed after 2 weeks and the effect of boron and fish oil was evaluated using Scanning Electron Microscope, Energy Dispersive x-ray analysis and Serum alkaline phosphatase level analysis. The data obtained was tabulated and subjected to statistical analysis. RESULTS: After 2 weeks of extraction, scanning Electron Microscopic results revealed an increase in trabecular bone thickness with regular bone surface, and uniform osteocyte lacunae in Group II (boron) in comparison to group I (control) and Group III (fish oil) and these results were proved by EDXA which showed increase in Ca level in group II than group I and group III. On the other hand, serum alkaline phosphatase analysis showed that group III (fish oil) has the higher level of ALP after 2 weeks of the experiment. CONCLUSION: Boron and fish oil systemic administration have a positive effect on socket healing and bone structure and composition in rats.

show abstract

Section: Discussionsupporting

confidence: 76%

Scannining Electron Microscopic Evaluation of the Effect of Boron and Fish Oil on Healing of Extraction Sockets in Rats

AbdElfatah

Samad

Koura

et al. 2020

Alexandria Dental Journal

View full text Add to dashboard Cite

show abstract

“…The whole process ensured that the operation was gentle to avoid of alveolus damage. Every five mice were sacrificed at 0, 3, 7, and 14 days after surgery for immunostaining and micro-CT analysis (Guo, Hu, Liu, Bao, & Wang, 2019).…”

Section: Murine Tooth Extraction Modelmentioning

confidence: 99%

H‐type blood vessels participate in alveolar bone remodeling during murine tooth extraction healing

et al. 2020

View full text Add to dashboard Cite

Objectives We aimed to investigate whether skeletal‐specific H‐type blood vessels exist in alveolar bone and how they function in alveolar bone remodeling. Materials and Methods H‐type vessels with high expression of CD31 and Endomucin (CD31hiEmcnhi) were immunostained in alveolar bone. Abundance and age‐related changes in CD31hiEmcnhi endothelial cells (H‐ECs) were detected by flow cytometry. Osteoprogenitors association with H‐type vessels and bone mass were detected in tooth extraction model of alveolar bone remodeling by immunohistofluorescence and micro‐CT, respectively. Transcription and expression of H‐EC feature genes during in vitro Notch inhibition were measured by RT‐qPCR and immunocytofluorescence. Results We verified that H‐type vessels existed in alveolar bone, the abundance of which was highest at infancy age, then decreased but maintained a constant level during aging. In tooth extraction model, H‐ECs significantly increased with concomitant perivascular accumulation of Runx2+ osteoprogenitors and gradually augmentation of bone mass. Notch inhibition of in vitro cultured H‐ECs resulted in decreased expression levels of Emcn and hes1, but not Pecam1 or Kdr genes, with decreased expression levels of H‐EC numbers, accordingly. Conclusions The present study suggests that H‐type vessels promote osteogenesis during alveolar bone remodeling. Notch signaling pathway regulates expression of Emcn and possibly determines fate and functions of alveolar H‐ECs.

show abstract

“…During the coagulation phase, the platelets release chemokines, growth factors, and matrix components [ 2 ]. Moreover, during inflammation, cells are recruited and are able to migrate [ 3 , 4 ]. Subsequently, highly vascularized granulation tissue is produced, which is able to improve tissue oxygenation and nutrient supply.…”

Section: Introductionmentioning

confidence: 99%

Healing of Alveolar Sockets Treated with Concentrated Growth Factors: A Split-Mouth Study

et al. 2022

View full text Add to dashboard Cite

Background: tooth extraction is a common procedure in oral surgery. The socket healing process involves hard and soft tissues and is characterized by intense remodeling, which may determine consistent dimension changes. Several autologous platelet concentrates (APCs) proved to be effective for enhancing alveolar socket healing after tooth extraction, accelerating socket closure and countering alveolar bone resorption. Concentrated growth factors (CGFs) are one of the most recently developed APCs, and their effect on the socket healing process still needs to be confirmed. Aim: The aim of the present split-mouth study was to evaluate the effectiveness of CGFs in enhancing the healing process in the postextraction alveolar socket and reducing postoperative pain. Methods: One hundred and fifty-four extractions were performed. One of the extraction sockets of each patient was treated with CGFs (test site), and the other socket was unfilled (control site). The main outcomes were: healing index, alveolar dimensions at the crestal level, socket closure, and pain perception. Descriptive statistics of the results were analyzed. Follow-up data were compared to baseline using paired tests. Results: The healing index on day 7 was significantly better (p < 0.001) in the test group (5.01 ± 1.30) as compared to the control group (6.65 ± 1.41). The mean visual analog scale for pain (VAS) was significantly higher for the control group when compared to the CGF group in the first 5 days postextraction. There was a trend toward greater socket closure in the CGF group, indicating faster healing, as compared to the control group at 7, 14, and 21 days. Conclusions: CGFs can represent a useful adjunctive tool, considering their mechanical and biological properties, for improving alveolar socket healing and reducing postoperative patient discomfort.

show abstract

The effect of haemostatic agents on early healing of the extraction socket

Cited by 10 publications

References 36 publications

Scannining Electron Microscopic Evaluation of the Effect of Boron and Fish Oil on Healing of Extraction Sockets in Rats

Scannining Electron Microscopic Evaluation of the Effect of Boron and Fish Oil on Healing of Extraction Sockets in Rats

H‐type blood vessels participate in alveolar bone remodeling during murine tooth extraction healing

Healing of Alveolar Sockets Treated with Concentrated Growth Factors: A Split-Mouth Study

Contact Info

Product

Resources

About