The effect of group‐based lifestyle interventions on risk factors and insulin resistance in subjects at risk for metabolic syndrome: the Tabaruzaka Study 1

Yamashiro, Tsuyoshi; Nishikawa, Takeshi; Isami, Satoshi; Wei, Chang Nian; Fukumoto, Kumiko; Matsuo, Hiroshi; Yoshinaga, Tomoaki; Kukidome, Daisuke; Motoshima, Hiroyuki; Matsumura, Takeshi; Ueda, Atsushi; Araki, Eiichi

doi:10.1111/j.1463-1326.2010.01236.x

Cited by 11 publications

(13 citation statements)

References 28 publications

(40 reference statements)

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“…The quantitative insulin-sensitivity check index (QUICKI), homeostasis model assessment of insulin resistance (HOMA-IR), HOMA-β, composite whole body insulin sensitivity index (cWBISI) and insulinogenic index (I.I.) were determined, as described previously ( Yamashiro et al, 2010 ).…”

Section: Methodsmentioning

confidence: 99%

Mild Electrical Stimulation with Heat Shock Reduces Visceral Adiposity and Improves Metabolic Abnormalities in Subjects with Metabolic Syndrome or Type 2 Diabetes: Randomized Crossover Trials

et al. 2014

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BackgroundThe induction of heat shock protein (HSP) 72 by mild electrical stimulation with heat shock (MES + HS), which improves visceral adiposity and insulin resistance in mice, may be beneficial in treating metabolic syndrome (MS) or type 2 diabetes mellitus (T2DM).MethodsUsing open-label crossover trials, 40 subjects with MS or T2DM were randomly assigned using computer-generated random numbers to 12 weeks of therapeutic MES + HS followed by 12 weeks of no treatment, or vice versa. During the intervention period, physical and biochemical markers were measured.FindingsCompared to no treatment, MES + HS treatment was associated with a significant decrease in visceral adiposity (− 7.54 cm2 (− 8.61%), 95% CI − 8.55 to − 6.53 (p = 0.037) in MS, − 19.73 cm2 (− 10.89%), 95% CI − 20.97 to − 18.49 (p = 0.003) in T2DM). Fasting plasma glucose levels were decreased by 3.74 mg/dL (− 5.28%: 95% CI − 4.37 to − 3.09 mg/dL, p = 0.029) in MS and by 14.97 mg/dL (10.40%: 95% CI − 15.79 to 14.15 mg/dL, p < 0.001) in T2DM, and insulin levels were also reduced by 10.39% and 25.93%, respectively. HbA1c levels showed a trend toward reduction (− 0.06%) in MS, and was significantly declined by − 0.43% (95% CI − 0.55 to − 0.31%, p = 0.009) in T2DM. HbA1c level of less than 7.0% was achieved in 52.5% of the MES + HS-treated T2DM patients in contrast to 15% of the non-treated period. Several insulin resistance indices, inflammatory cytokines or adipokines, including C-reactive protein, adiponectin, and tumor necrosis factor-α, were all improved in both groups. In isolated monocytes, HSP72 expression was increased and cytokine expression was reduced following MES + HS treatment. Glucose excursions on meal tolerance test were lower after using MES + HS in T2DM.InterpretationThis combination therapy has beneficial impacts on body composition, metabolic abnormalities, and inflammation in subjects with MS or T2DM. Activation of the heat shock response by MES + HS may provide a novel approach for the treatment of lifestyle-related diseases.FundingFunding for this research was provided by (Grants-in-Aid for Scientific Research from Ministry of Education, Culture, Sports, Science and Technology, Japan).

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Section: Methodsmentioning

confidence: 99%

Mild Electrical Stimulation with Heat Shock Reduces Visceral Adiposity and Improves Metabolic Abnormalities in Subjects with Metabolic Syndrome or Type 2 Diabetes: Randomized Crossover Trials

et al. 2014

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“…In a US study among 279 adult men and women with MS, only body weight and waist circumference were significantly decreased by a 12-month computer-based intervention of physical activity and diet 13) . Similarly, Japanese studies among subjects who had at least one component of MS have also observed significant decreases in body weight, fasting glucose or glycated hemoglobin in intervention groups; however, a beneficial effect of intervention on blood pressure, total cholesterol or triglyceride has not been observed [5][6][7] . Among persons with MS, lifestyle intervention was focused on weight control, although physical activity and diet may have a favorable effect on body weight, waist circumference and glucose metabolism but have no or limited effect on blood pressure and lipid profile.…”

Section: Discussionmentioning

confidence: 98%

“…On the other hand, in an Italian study among subjects with MS and those who had two MS components and a high level of high-sensitivity C-reactive protein (hs-CRP) 4) , the intervention group showed a significantly greater reduction in the prevalence of MS than the control group. In some Japanese studies, lifestyle intervention in adults who had an unfavorable profile in terms of cardiometabolic risk factors [5][6][7] has been shown to improve components of MS. To our knowledge, however, no study has examined the effect of intervention among subjects who met the Japanese definition of MS in Japan. …”

mentioning

confidence: 99%

Effect of Six Months Lifestyle Intervention in Japanese Men with Metabolic Syndrome: Randomized Controlled Trial

Nanri

Tomita

Matsushita

et al. 2012

Journal of Occupational Health

114

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215Akiko NANRI, et al.: Lifestyle Intervention and Metabolic Syndrome decreased. Conclusions: Although the tailor-made lifestyle modification program among men with MS did not provide an additional benefit in decreasing the prevalence of MS, it may help weight control and improve glucose metabolism. (J Occup Health 2012; 54: 215-222) Key words: Intervention, Lifestyle, Metabolic syndrome Metabolic syndrome (MS), which consists of abdominal obesity, hypertension, hyperglycemia and hyperlipidemia, is associated with increased risk of type 2 diabetes and cardiovascular disease. The prevalence of MS has been remarkably increasing worldwide over the past two decades 1) . In Japan, in particular, the prevalence of MS was 26.9% for adult men and 9.9% for adult women in 2007 2) . Therefore, an effective strategy against MS is urgently needed.Lifestyle modification against overweight, physical inactivity and an atherogenic diet have been recommended as a foundation for management of MS 1). A few controlled-intervention studies among subjects with MS have examined the effect of lifestyle intervention. In a Korean study among subjects with MS 3) , the prevalence of MS did not significantly differ between intervention and control groups after six months. On the other hand, in an Italian study among subjects with MS and those who had two MS components and a high level of high-sensitivity C-reactive protein (hs-CRP) 4) , the intervention group showed a significantly greater reduction in the prevalence of MS than the control group. In some Japanese studies, lifestyle intervention in adults who had an unfavorable profile in terms of cardiometabolic risk factors 5-7) has been shown to improve components of MS. To our knowledge, however, no study has examined the effect of intervention among subjects who met the Japanese definition of MS in Japan. Department of Epidemiology and Prevention, International Clinical Research Center, National Center for Global Health and Medicine-Objectives:The prevalence of metabolic syndrome (MS) has been remarkably increasing worldwide. However, few studies have examined the effect of lifestyle intervention among subjects with MS. We investigated the effect of a sixmonth lifestyle modification program on the prevalence of MS and its associated biomarkers among Japanese men with MS. Methods: Subjects were randomly assigned to either the intervention (n=53) or control (n=54) group. Subjects in the intervention group received a lifestyle modification program focused on exercise and diet behavior from a trained occupational health nurse at the baseline and at one and three months. The effect of intervention was assessed by differences in changes in the prevalence of MS, its components and associated biomarkers between the two groups. Results: Of the 107 participants, 102 completed the survey at the end of six months (intervention group, n=49; control group, n=53). During the study period, the prevalence of MS decreased to 65.3% and 62.3% in the intervention group and control group, respectively....

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“…[51] Konu ile ilgili yapılan randomize kontrollü çalışmalarda beslenme ve egzersiz ile ilgili girişimlerin metabolik sendrom riskini azaltmada etkili olduğu belirtilmiştir. [52][53][54][55] Araştırmanın Sınırlılıkları…”

Section: Discussionunclassified

Metabolic Syndrome Among Office Workers

Balcı¹

2018

J Cardiovasc Nurs

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Bu çalışmanın amacı ofis çalışanlarında metabolik sendrom sıklığını belirlemektir. Yöntemler: Tanımlayıcı-kesitsel tipteki araştırmanın evrenini Ocak 2017-Nisan 2017 arasında İstanbul'da özel bir banka ve şirketin ofis çalışanları oluşturdu (n=1200). Bu evrenden anlamlılık düzeyi 0.05, %95 güven aralığında, örneklem sayısı hesaplandı (n=344), ancak örneklemin %40.6'sına ulaşıldı (n=140). Veriler, Kişisel Bilgi Formu ve NCEP-ATP III tanı kriterleri ile toplandı. NCEP-ATP III tanı kriterleri için çalışanların kan basıncı, boy, kilo, bel çevresi ölçümleri yapıldı, trigliserid düzeyi, HDL ve açlık kan şekeri değerini belirlemek için işyeri sağlık ofisinde kanları alındı. Verilerin analizinde tanımlayıcı istatistikler (sayı, yüzde, ortalama), ki kare testi kullanıldı. Bulgular: Çalışanların %50'si kadın, %62.1'i evli, %52.9'unun eğitim düzeyi lisans ve üzeri, %22.9'unun kronik hastalığı bulunmakta, %36.4'ü sigara kullanmakta, %42.9'u normal kilolu, %36.4'ü ise fazla kiloludur. Abdominal obezite oranı kadınlarda %45.7, erkeklerde %28.6'di. Tüm çalışanlarda MetS sıklığı %18.6 olarak bulundu. Kadınlarda bu oran %17.1, erkeklerde ise %20'di. MetS sıklığı evlilerde, kronik hastalığı olanlarda, 41-60 yaş arası olanlarda, masa başında günlük çalışma süresi sekiz saat üzeri olanlarda istatiksel olarak anlamlı daha yüksekti (p<.05). Sonuç: Sonuç olarak ofis çalışanlarında metabolik sendromun önlenmesi ve erken tanısı için işyerlerinde sağlığı geliştirme programları oluşturulmalıdır.

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The effect of group‐based lifestyle interventions on risk factors and insulin resistance in subjects at risk for metabolic syndrome: the Tabaruzaka Study 1

Abstract: Group-based lifestyle intervention could be an efficient way to prevent MS. Its effects were sustainable, at least in part, for 2 years. These effects may be mediated by an improvement in insulin sensitivity.

Cited by 11 publications

References 28 publications

Mild Electrical Stimulation with Heat Shock Reduces Visceral Adiposity and Improves Metabolic Abnormalities in Subjects with Metabolic Syndrome or Type 2 Diabetes: Randomized Crossover Trials

Mild Electrical Stimulation with Heat Shock Reduces Visceral Adiposity and Improves Metabolic Abnormalities in Subjects with Metabolic Syndrome or Type 2 Diabetes: Randomized Crossover Trials

Effect of Six Months Lifestyle Intervention in Japanese Men with Metabolic Syndrome: Randomized Controlled Trial

Metabolic Syndrome Among Office Workers

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