The Effect of Grape Seed Extract on Cardiovascular Risk Markers: A Meta-Analysis of Randomized Controlled Trials

Feringa, Harm H.H.; Laskey, Dayne; Dickson, Justine E.; Coleman, Craig I.

doi:10.1016/j.jada.2011.05.015

Cited by 138 publications

(104 citation statements)

References 33 publications

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“…GP also contains substantial amount of non-digestible fiber (60%-70%), essential fatty acids (13%-19%), proteins (11%), as well as non-phenolic tocopherols, betacarotene, and minerals [6,7]. The polyphenolics from GP are known for their antioxidant and anti-inflammatory effects [8,9], which demonstrate preventive effects on cancer [10], cardiovascular diseases [11], and inflammatory bowel disease [12]. The GP polyphenolics have been used in food technology as antioxidants to inhibit the oxidation of fish lipids, frozen fish muscle, and fish oil [13].…”

Section: Introductionmentioning

confidence: 99%

Stability and Functionality of Grape Pomace Used as a Nutritive Additive During Extrusion Process

Bibi¹,

Rj²,

Zhang³

et al. 2017

J Food Process Technol

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Grape pomace (GP) is a major byproduct of wine and juice industry, rich in polyphenolics with demonstrated health benefits. Extrusion processing for development of healthy and quality GP supplemented cornstarch snack foods was evaluated using response surface methodology. The retainability of polyphenolic content and antioxidant activity after extrusion processing were further assessed. The processing variables were feed moisture (16, 20, and 24 ± 0.2% w.b.), screw speed (150, 200, and 250 rpm), and the level of GP supplementation (0, 5, and 10% w/w). Extrudates with 5% GP and 16 ± 0.2% feed moisture had a high overall expansion ratio of 3.83 ± 0.14, and overall low density (0.11 ± 0.00 g/cm 3 ). Total polyphenolic content (TPC) of the extrudates (5% GP, and 16% feed moisture) extruded at 150 and 250 rpm retained up to 74.1% and 78.57% respectively, while TPC was retained at 95% when extruded under 200 rpm with 10% GP and 16% feed moisture. Additionally, the total antioxidant activity and 2,2-diphenyl-1-picrylhydrazyl scavenging activity of the 5% GP extrudates retained 98% after extrusion processing. Moreover, polyphenolic extract of 5% GP extrudates suppressed reactive oxygen species in Caco-2 cells induced by hydrogen peroxide. In conclusion, GP incorporation in cornstarch extrudates improved both the physicochemical quality as well as nutritional value of products. Our study indicates that GP can be effectively incorporated into extruded foods by providing enhanced nutritional value without losing the expansion characteristics.

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Section: Introductionmentioning

confidence: 99%

Stability and Functionality of Grape Pomace Used as a Nutritive Additive During Extrusion Process

Bibi¹,

Rj²,

Zhang³

et al. 2017

J Food Process Technol

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“…It has been demonstrated that the procyanidins possess a lipid lowering effect, at the same time that they provoke an increase in the levels of cholesterol tied to HDL, and a decrease of the levels of cholesterol tied to LDL [20][21][22][23][24][25]. It is probable that this effect is demonstrated across other mechanisms which are different to the reduction of lipids, like antioxidant activities, including the sweeping of hydroxyl and peroxyl radicals and the inhibition of the oxidation of LDL [26]. In the present study, an increase was obtained in the c-HDL/c-LDL quotient in plasma and a reduction in the values of TG in blood in the GP and GPEF groups, which represents a clearly anti-atherogenic situation.…”

Section: Discussionmentioning

confidence: 99%

Effects of Combinational Procyanidins in Grape Seed Extract and Exercise on the Levels of Glucose and Blood Lipid Profile

F¹,

Guisado-Requena²,

Fuente³

et al. 2017

J Diabetes Metab

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The oxygenation process is essential for life and cellular activity, and therefore for physical exercise. During physical exercise an oxidative stress situation is produced, which can result in cellular oxidation and alterations in the immune system, causing cells to age prematurely. To prevent this, it is recommended to use high concentrations of antioxidants to minimize this process.The phenolic compounds of the flavonoid family, among which are the procyanidins, have shown neuroprotective effects, and cardioprotective effects. The cardiovascular protection and antiatherogenic effects of procyanidins have been attributed to the antioxidant properties of these phenolic compounds derived from its chemical structure. Different studies have shown the cardioprotective effects of chronic ingestion of procyanidins on models of hyperglycemia and dyslipidemia.This study aims to present the properties of these compounds and their protective effects on the cardiovascular system, setting markers of the primary action of procyanidins from grape seed extract (obtained by discarding the pulp and preserving the seeds) in plasma. A secondary aim of this study was to provide information on the molecular mechanisms by which these substances exert their cardioprotective effect and implement these into a recommended dietary regime. This would be used in appropriate doses and complement the protective and regulatory effect of exercise.

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“…Pomegranate juice reduces serum ACE activity by 36%, and has anti-atherogenic, antioxidant and anti-inflammatory effects [302,303] . Pomegranate juice at 50 mL/d reduced carotid IMT by 30% over one year, increased PON 83%, decreased oxLDL by 59%-90%, decreased antibodies to oxLDL by 19%, increased total antioxidant status by 130 %, reduced TGF-β, increased catalase, SOD and GPx, increased eNOS and NO and improved endothelial function [304,305] .…”

Section: Additional Compoundsmentioning

confidence: 99%

“…Grape seed extract (GSE) was administered to subjects in nine randomized trials, meta-analysis of 390 subjects and demonstrated a significant reduction in SBP of 1.54 mmHg (p < 0.02) [304,305] . Significant reduction in BP of 11/8 mmHg (p < 0.05) were seen in another dose response study with 150 to 300 mg/d of GSE over 4 wk [306] .…”

Section: Additional Compoundsmentioning

confidence: 99%

The role of nutrition and nutraceutical supplements in the treatment of hypertension

Houston¹

2014

WJC

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Vascular biology, endothelial and vascular smooth muscle and cardiac dysfunction play a primary role in the initiation and perpetuation of hypertension, cardiovascular disease and target organ damage. Nutrientgene interactions and epigenetics are predominant factors in promoting beneficial or detrimental effects in cardiovascular health and hypertension. Macronutrients and micronutrients can prevent, control and treat hypertension through numerous mechanisms related to vascular biology. Oxidative stress, inflammation and autoimmune dysfunction initiate and propagate hypertension and cardiovascular disease. There is a role for the selected use of single and component nutraceutical supplements, vitamins, antioxidants and minerals in the treatment of hypertension based on scientifically controlled studies which complement optimal nutrition, coupled with other lifestyle modifications.© 2014 Baishideng Publishing Group Co., Limited. All rights reserved.Key words: Hypertension; Nutrition; Nutritional supplements; Cardiovascular disease; Vascular biology Core tip: Vascular biology and endothelial dysfunction play a primary roles in hypertension and subsequent cardiovascular disease. Micronutrients, macronutrients and optimal nutrition and nutritional supplements can prevent, control and treat hypertension through numerous mechanisms related to vascular biology. These treatments are complementary to drug therapy. Oxidative stress, inflammation and autoimmune dysfunction initiate and propagate hypertension and cardiovascular disease. There is a role for the selected use of single and component nutraceutical supplements, vitamins, antioxidants and minerals in the treatment of hypertension based on scientifically controlled studies which complement optimal nutrition, coupled with other lifestyle modifications.Houston M. The role of nutrition and nutraceutical supplements in the treatment of hypertension. World J Cardiol 2014; 6(2): 38-66 Available from:

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The Effect of Grape Seed Extract on Cardiovascular Risk Markers: A Meta-Analysis of Randomized Controlled Trials

Cited by 138 publications

References 33 publications

Stability and Functionality of Grape Pomace Used as a Nutritive Additive During Extrusion Process

Stability and Functionality of Grape Pomace Used as a Nutritive Additive During Extrusion Process

Effects of Combinational Procyanidins in Grape Seed Extract and Exercise on the Levels of Glucose and Blood Lipid Profile

The role of nutrition and nutraceutical supplements in the treatment of hypertension

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