The Effect of Gold Nanoparticles on Chemo and Radiotherapy of Brain Tumor Cells

Vajrala, Gangadhar; Maricar, S. Mohamed ManjoorShaib; Thammineni, P.R.; Raya, C.N.; Vidiyala, S.K.; Madigubba, Sailaja; Panigrahi, Manas

doi:10.1016/j.ijrobp.2020.07.1658

Cited by 1 publication

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“…Different researches have also highlighted the potential of AuNPs as multifunctional tools for simultaneous brain cancer imaging and therapy. In particular, AuNPs could be used as diagnostic tool thanks their accumulation in the cancer brain tissue and, after irradiation, as therapeutic tools [ 69 , 76 ].…”

Section: Inorganic Nano-systems For Pediatric Brain Cancer Diagnosis and Therapymentioning

confidence: 99%

Nanoparticles for Diagnosis and Target Therapy in Pediatric Brain Cancers

et al. 2022

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Pediatric brain tumors represent the most common types of childhood cancer and novel diagnostic and therapeutic solutions are urgently needed. The gold standard treatment option for brain cancers in children, as in adults, is tumor resection followed by radio- and chemotherapy, but with discouraging therapeutic results. In particular, the last two treatments are often associated to significant neurotoxicity in the developing brain of a child, with resulting disabilities such as cognitive problems, neuroendocrine, and neurosensory dysfunctions/deficits. Nanoparticles have been increasingly and thoroughly investigated as they show great promises as diagnostic tools and vectors for gene/drug therapy for pediatric brain cancer due to their ability to cross the blood–brain barrier. In this review we will discuss the developments of nanoparticle-based strategies as novel precision nanomedicine tools for diagnosis and therapy in pediatric brain cancers, with a particular focus on targeting strategies to overcome the main physiological obstacles that are represented by blood–brain barrier.

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Section: Inorganic Nano-systems For Pediatric Brain Cancer Diagnosis and Therapymentioning

confidence: 99%