The Effect of Gold and Iron-Oxide Nanoparticles on Biofilm-Forming Pathogens

Sathyanarayanan, M.; Balachandranath, Reneta; Srinivasulu, Yuvasri Genji; Kumar, K. Sathish; Subbiahdoss, Guruprakash

doi:10.1155/2013/272086

Cited by 86 publications

(43 citation statements)

References 20 publications

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“…26 In addition, metal or metal oxide nanoparticles, such as silver, gold, iron oxide, and zinc oxide, have been developed to effectively control microbial biofilms through penetrating biopolymer matrix and causing damage to the cell walls. [27][28][29] Apart from the materials already mentioned, silica nanoparticles with nitric oxide donators also exhibit potent antibiofilm efficiency. 6 Moreover, Slomberg et al found that the decreased size and increased aspect ratio could enhance the anti-biofilm efficiency of the NO-releasing silica nanoparticles.…”

Section: Discussionmentioning

confidence: 99%

The spherical nanoparticle-encapsulated chlorhexidine enhances anti-biofilm efficiency through an effective releasing mode and close microbial interactions

Wong

et al. 2016

IJN

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We reported two forms (sphere and wire) of newly fabricated chlorhexidine (CHX)-loaded mesoporous silica nanoparticles (MSNs), and investigated their releasing capacities and anti-biofilm efficiencies. The interactions of the blank MSNs with planktonic oral microorganisms were assessed by field emission scanning electron microscopy. The anti-biofilm effects of the two forms of nanoparticle-encapsulated CHX were examined by 2,3-bis (2-methoxy- 4-nitro-5-sulfo-phenyl)-2H-tetrazolium-5-carboxanilide. The profiles of biofilm penetration were analyzed by fluorescent-labeled MSNs using confocal microscopy and ImageJ. The spherical MSNs with an average diameter of 265 nm exhibited a larger surface area and faster CHX-releasing rate than the MSN wires. The field emission scanning electron microscopy images showed that both shaped MSNs enabled to attach and further fuse with the surfaces of testing microbes. Meanwhile, the nanoparticle-encapsulated CHX could enhance the anti-biofilm efficiency with reference to its free form. Notably, the spherical nanoparticle-encapsulated CHX presented with a greater anti-biofilm capacity than the wire nanoparticle-encapsulated CHX, partly due to their difference in physical property. Furthermore, the relatively even distribution and homogeneous dispersion of spherical MSNs observed in confocal images may account for the enhanced penetration of spherical nanoparticle-encapsulated CHX into the microbial biofilms and resultant anti-biofilm effects. These findings reveal that the spherical nanoparticle-encapsulated CHX could preferably enhance its anti-biofilm efficiency through an effective releasing mode and close interactions with microbes.

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Section: Discussionmentioning

confidence: 99%

The spherical nanoparticle-encapsulated chlorhexidine enhances anti-biofilm efficiency through an effective releasing mode and close microbial interactions

Wong

et al. 2016

IJN

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“…Sathyanarayanan et al 248 explained about the challenges in eliminating the microbial biofilms in implant biomaterials or devices by antibiotics. They observed that exopolymeric substances protect the microorganisms from most of the antibiotics and make the cell immune.…”

Section: Goldmentioning

confidence: 99%

Nanotechnology-based drug delivery systems for control of microbial biofilms: a review

Ramos¹,

Silva²,

Spósito³

et al. 2018

IJN

200

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Since the dawn of civilization, it has been understood that pathogenic microorganisms cause infectious conditions in humans, which at times, may prove fatal. Among the different virulent properties of microorganisms is their ability to form biofilms, which has been directly related to the development of chronic infections with increased disease severity. A problem in the elimination of such complex structures (biofilms) is resistance to the drugs that are currently used in clinical practice, and therefore, it becomes imperative to search for new compounds that have anti-biofilm activity. In this context, nanotechnology provides secure platforms for targeted delivery of drugs to treat numerous microbial infections that are caused by biofilms. Among the many applications of such nanotechnology-based drug delivery systems is their ability to enhance the bioactive potential of therapeutic agents. The present study reports the use of important nanoparticles, such as liposomes, microemulsions, cyclodextrins, solid lipid nanoparticles, polymeric nanoparticles, and metallic nanoparticles, in controlling microbial biofilms by targeted drug delivery. Such utilization of these nanosystems has led to a better understanding of their applications and their role in combating biofilms.

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“…Therefore, these nanoparticles demonstrated strong antimicrobial activity with high toxicity. 76,94 ZnO nanoparticles: ZnO NPs are very effective antimicrobial agents and are efficient against both, grampositive and gram-negative bacteria, in addition to the thermophilic and barophilic spores. [95][96] The metal oxide, ZnO, has many applications involving their use as solar cells, detectors, displays, gasoline detectors, piezoelectric units, varistors, electro-acoustic transducers, sun-screens, anti-reflection films, photo-diodes accompanied by UV light emitters, UV absorbers, and photocatalysts.…”

Section: 76mentioning

confidence: 99%

Antimicrobial Treatment of Different Metal Oxide Nanoparticles: A Critical Review

Parham

Wicaksono

Bagherbaigi

et al. 2016

J Chinese Chemical Soc

121

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Many nanomaterials can be used as metal oxides (Ti, Ag, Zn, Cu, Mg, Ca, Ce, Yt, Al). Metal oxide nanoparticles have strong antimicrobial properties. The oxides that play a large role as antimicrobial agents can be divided into two major groups based on their mechanism of action i.e., those that involve oxidation and those that inhibit the production of Reactive Oxygen Species (ROS). Previous studies have shown that, toxic metals like silver and titanium, and their metals oxides, employ the ROS-mediated mechanism that leads to oxidative stress-related cytotoxicity, cancer, and heart diseases. Oxidative stress further leads to increased ROS production and also delays the cellular processes involved in wound healing. Other metal oxide nanoparticles, like Y 2 O 3 , CeO 2 and Al 2 O 3 act as free radical scavengers. Out of these, aluminium oxide nanoparticles are more effective antimicrobial agents, than the other metal oxide nanoparticles. A combination of Al 2 O 3 and other antimicrobial agents such as TiO 2 may act as ideal antimicrobial agents, along with possessing free radical scavenging activity. This critical review aims to study the antimicrobial properties of different metal oxide nanoparticles and the mechanism of action involved, besides comparing their efficacy to eliminate bacteria.

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The Effect of Gold and Iron-Oxide Nanoparticles on Biofilm-Forming Pathogens

Cited by 86 publications

References 20 publications

The spherical nanoparticle-encapsulated chlorhexidine enhances anti-biofilm efficiency through an effective releasing mode and close microbial interactions

The spherical nanoparticle-encapsulated chlorhexidine enhances anti-biofilm efficiency through an effective releasing mode and close microbial interactions

Nanotechnology-based drug delivery systems for control of microbial biofilms: a review

Antimicrobial Treatment of Different Metal Oxide Nanoparticles: A Critical Review

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