The effect of glutamine supplementation on serum levels of some inflammatory factors, oxidative stress, and appetite in COVID-19 patients: a case–control study

Mohajeri, Mahsa; Horriatkhah, Ehsan; Mohajery, Reza

doi:10.1007/s10787-021-00881-0

Cited by 21 publications

(23 citation statements)

References 43 publications

(51 reference statements)

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“…Glutamate negatively correlates with the pro-inflammatory cytokines IL-6 and IL-18 but positively correlates with (especially CD4 + ) T cells [ 44 , 63 , 95 ]. Of note, nutritional glutamine supplementation caused a decrease of IL-1β, TNF-α and high-sensitivity C-reactive protein (hs-CRP), in COVID-19 patient sera, compared to the non-supplemented control group [ 103 ]. These finding establish the role of glutamine depletion in the pathogenesis of COVID-19.…”

Section: Mechanistic Biomarkers Of Covid-19mentioning

confidence: 99%

Diagnostic, Prognostic and Mechanistic Biomarkers of COVID-19 Identified by Mass Spectrometric Metabolomics

2023

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A number of studies have assessed the impact of SARS-CoV-2 infection and COVID-19 severity on the metabolome of exhaled air, saliva, plasma, and urine to identify diagnostic and prognostic biomarkers. In spite of the richness of the literature, there is no consensus about the utility of metabolomic analyses for the management of COVID-19, calling for a critical assessment of the literature. We identified mass spectrometric metabolomic studies on specimens from SARS-CoV2-infected patients and subjected them to a cross-study comparison. We compared the clinical design, technical aspects, and statistical analyses of published studies with the purpose to identify the most relevant biomarkers. Several among the metabolites that are under- or overrepresented in the plasma from patients with COVID-19 may directly contribute to excessive inflammatory reactions and deficient immune control of SARS-CoV2, hence unraveling important mechanistic connections between whole-body metabolism and the course of the disease. Altogether, it appears that mass spectrometric approaches have a high potential for biomarker discovery, especially if they are subjected to methodological standardization.

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Section: Mechanistic Biomarkers Of Covid-19mentioning

confidence: 99%

Diagnostic, Prognostic and Mechanistic Biomarkers of COVID-19 Identified by Mass Spectrometric Metabolomics

2023

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“…Among the nutrients that affect immune function, vitamin D, magnesium, vitamin B 12 , and vitamin C have been reported to significantly reduce the proportion of severely ill patients and prolong survival [13,[16][17][18][19]. Although immuneboosting nutrients, such as glutamine, selenium, and zinc, reportedly have antiviral effects [13,20,21], appropriate supply levels, methods, types, and administration periods have yet to be established. European Society for Clinical Nutrition and Metabolism guidelines suggest providing the recommended daily amounts of vitamins and trace elements [8].…”

Section: Comparison With Previous Studiesmentioning

confidence: 99%

Effects of nutritional status and support on the survival of COVID-19 patients in a single tertiary-center intensive care unit in Korea: a case-control study

Lee

Kim

Kang

et al. 2023

Ann Clin Nutr Metab

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It is important to understand the nutritional status of critically ill COVID-19 patients and to provide adequate associated support. We attempted to determine how nutritional status and the amount of nutritional support provided to critically ill patients affect their survival. Methods: We retrospectively reviewed the medical records of patients admitted to the intensive care unit of Dong-A University Hospital between January and December 2021. We divided the patients into survivors and those who died during COVID-19 treatment and compared and analyzed their clinical parameters, nutrition-related indicators, nutritional status, and nutritional support. Results: Of 70 patients reviewed, 57 survived. Mortality was higher in the older group (P=0.006). The patients who underwent ventilator, extracorporeal membrane oxygenation, or continuous renal replacement therapy showed higher mortality. Nutritional status at the time of admission and the nutritional requirements did not differ among patient groups. However, the actual amounts of calories (P<0.001) and protein (P=0.019) supplied were lower in the mortality group. Serum C-reactive protein level was higher (P=0.002) and serum albumin level was lower in those who did not survive (P<0.001) compared with surviving patients at discharge. Conclusion:We did not determine whether the initial nutritional status of patients with COVID-19 affected their survival due to various factors associated with the severity of the disease. However, given the similarities between disease severity and nutritional status at the time of admission, our results indicate that adequate nutritional support can contribute to survival in critically ill COVID-19 patients with pneumonia.

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“… 53 Mohajeri et al found in a case‐controlled study that glutamine supplementation in Covid‐19 reduced the level of proinflammatory cytokines and associated complications. 54 …”

Section: The Link Between Covid‐19 and MMmentioning

confidence: 99%

“…53 Mohajeri et al found in a case-controlled study that glutamine supplementation in Covid-19 reduced the level of proinflammatory cytokines and associated complications. 54 Notably, expression of angiogenic factors, HIF-1, and glutamine deficiency could link Covid-19 severity and MM in the pathogenesis of cardiovascular complications.…”

Section: Cardiovascular Complicationsmentioning

confidence: 99%

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The potential link between Covid‐19 and multiple myeloma: A new saga

Al-Kuraishy

Al-Gareeb

Mohammed

et al. 2022

Immunity Inflam & Disease

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Background Covid‐19 is considered a primary respiratory disease‐causing viral pneumonia and, in severe cases, leads to acute lung injury and acute respiratory distress syndrome (ARDS). In addition, though, extra‐pulmonary manifestations of Covid‐19 have been shown. Furthermore, severe acute respiratory distress syndrome coronavirus type 2 (SARS‐CoV‐2) infection may coexist with several malignancies, including multiple myeloma (MM). Methods This critical literature review aimed to find the potential association between SARS‐CoV‐2 infection and MM in Covid‐19 patients with underlying MM. Narrative literature and databases search revealed that ARDS is developed in both MM and Covid‐19 due to hypercalcemia and proteasome dysfunction. Results Notably, the expression of angiogenic factors and glutamine deficiency could link Covid‐19 severity and MM in the pathogenesis of cardiovascular complications. MM and Covid‐19 share thrombosis as a typical complication; unlike thrombosis in Covid‐19, which reflects disease severity, thrombosis does not reflect disease severity in MM. In both conditions, thromboprophylaxis is essential to prevent pulmonary thrombosis and other thromboembolic disorders. Moreover, Covid‐19 may exacerbate the development of acute kidney injury and neurological complications in MM patients. Conclusion These findings highlighted that MM patients might be a risk group for Covid‐19 severity due to underlying immunosuppression and most of those patients need specific management in the Covid‐19 era.

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The effect of glutamine supplementation on serum levels of some inflammatory factors, oxidative stress, and appetite in COVID-19 patients: a case–control study

Cited by 21 publications

References 43 publications

Diagnostic, Prognostic and Mechanistic Biomarkers of COVID-19 Identified by Mass Spectrometric Metabolomics

Diagnostic, Prognostic and Mechanistic Biomarkers of COVID-19 Identified by Mass Spectrometric Metabolomics

Effects of nutritional status and support on the survival of COVID-19 patients in a single tertiary-center intensive care unit in Korea: a case-control study

The potential link between Covid‐19 and multiple myeloma: A new saga

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