The effect of glucocorticosteroid administration on fetal movements and biophysical profile scores in normal pregnancies

Jackson, J; Kleeman, Steven D.; Doerzbacher, Meg; Lambers, Donna S.

doi:10.1080/713605757

Cited by 2 publications

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“…However, the pregnancies in that study were more advanced (30–34 weeks) than those in the present study. Another study revealed a significant decrease in amniotic fluid volume between 0 and 48 hours after betamethasone administration but this study did not investigate the effects of betamethasone after 48 hours; however, in the present study the decrease was most apparent at 72 hours.…”

Section: Discussioncontrasting

confidence: 72%

“…In some pregnancies, steroid administration has been shown to result in placental vasodilatation, resulting in the temporary improvement of impaired fetoplacental blood flow; however, betamethasone administration has not been reported to cause any change in the fetoplacental vessels of fetuses with severe growth restriction . Other studies have evaluated the effects of steroids on the biophysical profile; these studies have revealed reductions in fetal movement, breathing, or amniotic fluid index (AFI), resulting in decreased biophysical profile scores . The present study investigated the unanticipated effects of betamethasone on fetomaternal blood flow and AFI.…”

Section: Introductionmentioning

confidence: 96%

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Effects of betamethasone on fetoplacental and maternal hemodynamics in preterm pregnancies

İnan

Sayın

Dolgun

et al. 2018

Intl J Gynecology & Obste

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Section: Discussioncontrasting

confidence: 72%

Section: Introductionmentioning

confidence: 96%

Effects of betamethasone on fetoplacental and maternal hemodynamics in preterm pregnancies

İnan

Sayın

Dolgun

et al. 2018

Intl J Gynecology & Obste

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“…French et al (2004) have recently evaluated a subset of children in their original study (1999) and demonstrated that children exposed to 3 or more courses of antenatal glucocorticoids exhibited significantly higher relative risks of externalizing behavioral disorder and distractibility at 3 and 6 years of age, without any changes in intelligence quotient [169]. Jackson et al (2003) have recently reported that 2 doses of maternal betamethasone significantly decreased biophysical profile scores in 28% of their study population and 44% of the patients reported a decrease in fetal movement [173]. Further, stress and anxiety during pregnancy have recently been reported to be associated with alterations in fetal growth and neonatal behavior.…”

Section: Effect Of Fetal Glucocorticoid Exposure: Human Studiesmentioning

confidence: 99%

Synthetic Glucocorticoids: Antenatal Administration and Long-term Implications

Sloboda¹,

Challis

Moss³

et al. 2005

CPD

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A clear relationship between intrauterine development and later life predisposition to long-term disease is well established. Weight at birth provides a surrogate measure for fetal development and low birth weight predicts changes in most endocrine axes in adulthood. The exposure of the fetus to elevated levels of either endogenous or synthetic glucocorticoids, pre and periconceptional nutritional status and immediate postnatal development including catch-up growth all contribute substantially to the development of adult onset disease. Fetal exposure to high levels of glucocorticoids has direct clinical relevance. Synthetic glucocorticoids (betamethasone/ dexamethasone) are administered to women at risk of preterm delivery to advance fetal maturation and reduce neonatal morbidity and mortality. However, in human pregnancy, evidence suggests that fetal exposure to synthetic glucocorticoids has detrimental effects on birth outcome, childhood cognition and long-term behavior. Studies in animals have established a link between prenatal exposure to synthetic glucocorticoids and alterations in fetal development as well as changes in placental function. These developmental alterations appear to be permanent. Whether this is the case in humans awaits long-term follow-up of children enrolled in randomized controlled trials of prenatal glucocorticoid therapy. The research challenges in this field are now centered on uncovering the mechanisms by which glucocorticoids are involved in programming the fetus for its future life, and discovering ways in which the effectiveness and safety of antenatal glucocorticoids can be enhanced. The purpose of this mini-review is to provide a background into the use of antenatal synthetic corticosteroids and to highlight and summarize recently published clinical and animal-based studies.

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The effect of glucocorticosteroid administration on fetal movements and biophysical profile scores in normal pregnancies

Cited by 2 publications

References 0 publications

Effects of betamethasone on fetoplacental and maternal hemodynamics in preterm pregnancies

Effects of betamethasone on fetoplacental and maternal hemodynamics in preterm pregnancies

Synthetic Glucocorticoids: Antenatal Administration and Long-term Implications

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