Effects of betamethasone on fetoplacental and maternal hemodynamics in preterm pregnancies

İnan, Cihan; Sayın, N. Cenk; Dolgun, Zehra Nihal; Erzincan, Selen Gürsoy; Uzun, Işıl; Sütçü, Havva; Süt, Necdet; Varol, Füsun

doi:10.1002/ijgo.12478

Cited by 2 publications

(4 citation statements)

References 26 publications

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“…Therefore, betamethasone could influence brain circulation. Concordant with the literature, DV PI remained unchanged in the present study [11,12,14,15].…”

Section: Division Of Worksupporting

confidence: 92%

“…Another study reported that umbilical artery PI was decreased in fetuses that develop RDS in the neonatal period [9]. İnan et al detected no significant change at umbilical PI, but there was a significant change at RI [15]. In our study, we detected no significant differences in the umbilical artery Doppler indices before and after steroid administration.…”

Section: Division Of Workcontrasting

confidence: 58%

“…Several studies have reported the effect of betamethasone on Doppler parameters of the MCA, and they found decreased or unchanged MCA PI levels in various patient groups [5,6,11,12,15]. In our study, except for MCA S/D, all other MCA Doppler indices had a significant change.…”

Section: Division Of Worksupporting

confidence: 58%

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Does betamethasone therapy impact fetal multivessel Doppler parameters?

Özdemir¹,

Çalış²,

Karçaaltıncaba³

et al. 2021

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Introduction: The objective of this study was to test the hypothesis that antenatal corticosteroid therapy alters fetal cardiopulmonary and uteroplacental blood flow in pregnancies. Material and methods: Twenty-seven singleton pregnancies between 28 and 34 gestational weeks classified as at risk of preterm birth were included prospectively. We evaluated fetal main pulmonary artery (MPA), left and right pulmonary artery (PA), left myocardial performance index (Tei index), tricuspid valve (TV), umbilical artery (UmA), middle cerebral artery (MCA), and ductus venosus (DV) parameters before and 48 hours and 7 days after antenatal steroid administration. Results: The mean age was 31 years, and the mean gestational age was 31 weeks. The UmA S/D (Systole/Diastole) ratio, PI (pulsatility index) and RI (resistive index) values, and Doppler parameters of other vessels were not different when comparing between before and after steroid administration. Except for MCA PSV (peak systolic velocity) values, the other MCA Doppler parameters (S/D, PI, RI) were all significantly decreased. The cerebroplacental ratio (CPR) and CPR percentile values decreased significantly. All tested cardiac parameters were unchanged, except MPA ejection time (ET) (p = 0.016). Conclusions: Our data demonstrate altered fetal MCA and CPR with corticosteroid therapy. These data suggest that antenatal corticosteroid therapy has no impact on any Doppler parameters of fetal cardiopulmonary and uteroplacental blood flow in pregnancies.

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“…Therefore, betamethasone could influence brain circulation. Concordant with the literature, DV PI remained unchanged in the present study [11,12,14,15].…”

Section: Division Of Worksupporting

confidence: 92%

Section: Division Of Workcontrasting

confidence: 58%

See 1 more Smart Citation

Does betamethasone therapy impact fetal multivessel Doppler parameters?

Özdemir¹,

Çalış²,

Karçaaltıncaba³

et al. 2021

pcard

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“…The haemodynamic effect of corticosteroids at foetal and postnatal level is well known [ 23 , 24 , 25 , 26 , 27 , 28 , 29 ]. The results of our investigation found greater haemodynamic stability, and a tendency to a better evolution of respiratory distress syndrome in the 12 h betamethasone group.…”

Section: Discussionmentioning

confidence: 99%

Antenatal Betamethasone Every 12 Hours in Imminent Preterm Labour

Saldaña-García

Espinosa-Fernández

Martínez-Pajares

et al. 2022

JCM

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Background: Benefits of antenatal corticosteroids have been established for preterm infants who have received the full course. In imminent preterm labours there is no time to administer the second dose 24 h later. Objective: To determine whether the administration of two doses of betamethasone in a 12 h interval is equivalent to the effects of a full maturation. Methods: We performed a retrospective cohort study including preterm infants ≤34 weeks gestational age at birth and ≤1500 g, admitted to an NICU IIIC level in a tertiary hospital from 2015 to 2020. The population was divided into two cohorts: complete maturation (CM) (two doses of betamethasone 24 h apart), or advanced maturation (AM) (two doses of betamethasone 12 h apart). The primary outcomes were mortality or survival with severe morbidities. The presence of respiratory distress syndrome and other morbidities of prematurity were determined. These variables were analysed in the neonates under 28 weeks gestational age cohort. Neurodevelopment at 2 years was evaluated with the validated Ages and Stages Questionnaires®, Third Edition (ASQ®-3). Multiple regression analyses were performed and adjusted for confounding factors. Results: A total of 275 preterm neonates were included. Serious outcomes did not show differences between cohorts, no increased incidence of morbidity was found in AM. A lower percentage of hypotension during the first week (p = 0.04), a tendency towards lower maximum FiO2 (p = 0.14) and to a shorter mechanical ventilation time (p = 0.14) were observed for the AM cohort. Similar results were found in the subgroup of neonates under 28 weeks gestational age. There were no differences in cerebral palsy or sensory deficits at 24 months of corrected age, although the AM cohort showed a trend towards better scores on the ASQ3 scale. Conclusions: Administration of betamethasone every 12 h showed similar results to the traditional pattern with respect to mortality and severe morbidities. No deleterious neurodevelopmental effects were found at 24 months of corrected age. Earlier administration of betamethasone at 12 h after the first dose would be an alternative in imminent preterm delivery. Further studies are needed to confirm these results.

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Effects of betamethasone on fetoplacental and maternal hemodynamics in preterm pregnancies

Abstract: Betamethasone had favorable effects on fetal cerebral circulation, with increased end-diastolic velocity in the middle cerebral artery; this could represent a positive effect on cerebral blood circulation and decreased flow resistance in the umbilical artery.

Cited by 2 publications

References 26 publications

Does betamethasone therapy impact fetal multivessel Doppler parameters?

Does betamethasone therapy impact fetal multivessel Doppler parameters?

Antenatal Betamethasone Every 12 Hours in Imminent Preterm Labour

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